Jitteriness: does it scale with dose; and why does it happen?
I've taken a 36 mg oral dose of 2C-C for the first time recently (see my
trip report here for details) and, although it was a lovely trip in many ways, I experienced quite uncomfortable jitters during the come-up, most intensely for 15 to 30 minutes between two and three hours after dosing. My legs (and other parts of my body) just couldn't stop moving. I've experienced something like this on 2C-E and, more notably, on DiPT; but I don't believe I've had it this bad before. Some caffeine had been consumed, but less - if anything - than I've usually had when taking other psychedelics in the past.
I have a few questions about this...
1) Those who have experienced such jitters on 2C-C: do you find that this scales with dose? In other words, if I got it bad at 36 mg, can I expect to get it worse at, say, 50 mg; or does this stay fairly constant across doses?
2) Do non-oral routes offer less or more of the jitters (in terms of duration or intensity)?
3) What on earth are these jitters? Various possibilities occur to me:
a) General stimulation
b) Objective temperature changes (e.g. fever) inducing shivers
c) A toxic reaction
d) Motor psychedelia (i.e. neurons in the motor cortex being stimulated in odd ways much as neurons in the visual cortex are stimulated in odd ways by psychedelics)
Of the above options, I'd hope that it was (d), as I think that's the only option that would be unlikely to have negative health consequences. By a staggering coincidence, option (d) is also the option I think is most likely...
It really doesn't seem anything like the sort of stimulation induced by true stimulants: the stimulation - if that's what it is - seems mostly confined to the legs, with heart rate not particularly notably raised (although I didn't take my pulse effectively during this experience, so I can't be sure). The jitters and discomfort went away as the peak of the other effects arrived, which seems to me to suggest toxicity is unlikely. Objective temperature changes are possible, I guess, but to induce such tremors one would need to be in high fever, and I don't believe I was in high fever: no other symptoms support that... I was not delirious, sweating, etc.
But what do you people think of this? Am I right to reject stimulation, fever, and toxicity as causes of the jitters during come-up? Is the idea of motor cortex psychedelia a reasonable one? Does anyone know of any research that could speak to this question?