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The Big & Dandy 25C-NBOMe Thread (part 2) ver. "My skin feels like lightning"

What [b]in your experience[/b] would be a maximum responsible buccal dose for 25C?

  • up to 400 μg

    Votes: 4 6.3%
  • up to 600 μg

    Votes: 11 17.5%
  • up to 900 μg

    Votes: 9 14.3%
  • up to 1200 μg

    Votes: 25 39.7%
  • up to 1500 μg

    Votes: 9 14.3%
  • a dose higher than 1500 μg

    Votes: 5 7.9%

  • Total voters
    63
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Thats a lot of 25c, do you fond it very underwhelming at doses lower than that?

Well it was my first time, and my body just seems very tolerant to the NBOMe family.
Don't know why. I found that dose to be very relaxing to me. Minor body load and zero vasoconstriction. Aside from minor chills, but it is cold in my house.

I don't advise that being anyone's starting dose of course because in can be dangerous. Personally, this is my 'sweet' spot for this particular NBOMe. With 25C my sweet spot is 1700ug with mild effects.

Moderator note: this is a huge dose of 25C and should absolutely not be taken as an example.
 
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Well it was my first time, and my body just seems very tolerant to the NBOMe family.
Don't know why. I found that dose to be very relaxing to me. Minor body load and zero vasoconstriction. Aside from minor chills, but it is cold in my house.

I don't advise that being anyone's starting dose of course because in can be dangerous. Personally, this is my 'sweet' spot for this particular NBOMe. With 25C my sweet spot is 1700ug with mild effects.

1700ug? Either you have a ridiculously high tolerance, or your material is adulterated. 1700ug is supposed to be a VERY HARD trip even for someone very experienced. Not a recommendable dosage at all!
 
1700ug? Either you have a ridiculously high tolerance, or your material is adulterated. 1700ug is supposed to be a VERY HARD trip even for someone very experienced. Not a recommendable dosage at all!

The 25I-NBOME was staggered doses, I kept redosing 900ug tabs over a 5 hour period. I got them from a very reliable source and they were lab tested by multiple people, including a friend. Even came with complete MSDS papers.
I even took 2000ug over a course of 30 minutes on my first experiment. My body has a high tolerance to any psychedelic it seems.
 
I am getting a sample of 25c that is dosed on blotter at 1mg. Ive done a decent amount of reading on the substance and before i try acid i want to try this as kind of a baby step. My question is if shit gets too crazy for me could i take a bunch of xanax and put myself down a little? Also i am on methadone maint, is there any interaction probs there? For a first timer id like to get the whole visual effect and all, would anyone suggest i split the blotter in half or go for the whole dunk? Oh, and on a completely unrelated note, has anyone ever seen pure psilocybin caps before? Not ground up shrooms in caps but a single cap with psilo in it? Would that be super rare or would it most likely be a tryptamine rc? Thanks for any input guys, this is kinda new old new territory for me. Also, i get migraines, whats the chance of this stuff giving me a migraine due to the vasoconstriction?
 
^
1tbh id start with acid first. 1mg 25c is way more visual than the standard hit of lsd.
2psili powder is usually 4-ho-dmt or 5-meo-dmt
3theres supplements that you can stock up ahead of time on like magnesium and potassium to counteract vasoconstriction.
 
Id love to try acid but i dont have a reliable source for it. I mean i know ppl who say they have it, but i dont trust them. Maybe take half the blotter then? Would i get good visuals and effect from .05mg? I can also get these supposed shroom caps that are supposed to be awesome. I kinda knew there was no psilocybin extract caps in a single dose cap. Figured it was an rc of some sort. Thanks for the info anymore would be helpful. Are the visuals from the 25c that crazy?
 
1700ug? Either you have a ridiculously high tolerance, or your material is adulterated. 1700ug is supposed to be a VERY HARD trip even for someone very experienced. Not a recommendable dosage at all!

Absolutely not true and it shows your inexperience on the subject (to quote what I told you before in that other thread)
Experience would have shown you that everyones natural tolerance to NBOMEs vary MASSIVELY without any built up tolerance in play.

Always be careful with NBOME drugs and start less then 500 ug no matter which one you do. If you dont feel it (and you might not if its not insufflated) wait 1 month and try a bigger dose once you've gotten a feel for it's effects. If you don't wait a month you'll fuck up your tolerance and have to bear with quitting phenethylamines and NBOMES for awhile. NBOMES give crazy tolerance so be care everyone.
 
I disagree, even for someone with natural tolerance, above 1000ug is a huge dose. A variation by ten or twenty percent is large, requiring a double dose is not natural tolerance.
 
As I said, either you've got a shitty vendor or you don't wait long enough for tolerance to dissipate. That said, maybe you're a bizarre exception and have unusually downregulated 5HT2a receptors. Or you have unusually high levels of enzymes responsible for breaking down psychedelics.

Transform, have you any idea if the NBOMe's are MAO substrates?
 
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I disagree, even for someone with natural tolerance, above 1000ug is a huge dose. A variation by ten or twenty percent is large, requiring a double dose is not natural tolerance.

I completely agree with you but experience on the subject shows this is just sometimes not true. There can be a large natural tolerance for NBOMEs in a small part of population.

Again never start with more than 500 ug of any NBOME, and wait for tolerance to go down to experiment with higher doses. With a trip sitter experienced with NBOMEs you can take up to a 1000 ug dose your first time, but not all at once obviously. You must titrate it slowly or you could easily overdose. That's why I don't recommend this unless you have an experienced sitter with you.

I'm not trying to go against HR at all, I'm just related personal experience.

For my first 25C trip I required 1-1.2 mg for the desired effects, this was with no NBOME tolerance.

As I said, either you've got a shitty vendor or you don't wait long enough for tolerance to dissipate. That said, maybe you're a bizarre exception and have unusually downregulated 5HT2a receptors. Or you have unusually high levels of enzymes responsible for breaking down psychedelics.

It could be due to a lot of things, tolerance maybe because I have abused nbome in the past as well as 2c's, but my vendor and drugs are most definitely pure.
My preferred routes are insufflation and vaporization for nbomes. They are great and easily titrated slowly to get the trip you want this way. Just make sure you know their specific effects on you before you do it this way.




BTW, the poll is completely unanswerable in my opinion. Each choice will be correct for different people, depending on their chemistry, and some people might really be able to enjoy/handle 3+ mg... I've heard of this but I don't know if tolerance was involved or not.

As always I recommend no more than 500 ug for an nbome you're new with.
 
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hello, what are the known side effects of taking 25C nBome regulary? I havent been using it for a long time, though last month was a bit too much (2 times a week, but only two times high doses). Does anybody know about the long term use effects? :)
 
Read all my posts in the last couple of pages in all the NBOME threads in the PD forum. The long term effects are massive serotonin receptor tolerance and maybe even damage/psychological problems like less motivation, anxiety, and irritability. Keep the nbomes to once a month at the very most. The side effects I mentioned are long time only from abuse of psychedelics repeatedly and the ensuing serotonin receptor changes, not side-effects from the drug itself.

Seriously, click on my name and click view forum posts, you'll learn a lot about NBOMEs (or my opinions at least)
 
It is an incredibly new drug and as a result we have almost no data about regular or long term use. I recall a post about a regular user who was having serious verbal memory problems and had met someone else suffering the same. I've little doubt there are other negatives to such receptor downregulation.
 
BTW, the poll is completely unanswerable in my opinion. Each choice will be correct for different people, depending on their chemistry, and some people might really be able to enjoy/handle 3+ mg... I've heard of this but I don't know if tolerance was involved or not.

As always I recommend no more than 500 ug for an nbome you're new with.

Yes, it's no problem if there are different answers given. You just need to interpret the results of the poll a little differently.

People should note the answers of lowest doses most of all, because it indicates that there is a chance for a person to find difficulties at or over that dosage level.
Actually the poll was created for us staff, to become more aware of those dosages so that we can edit in warnings if people are discussing doses that may be problematic if they are unlucky.
The poll may be removed soon, so that we can use the data to write up usable information and advice on dosage for each of the popular NBOMe compounds.

So is the poll "unanswerable", no I disagree, just not in a typical way. But we have a purpose for it.
 
It is an incredibly new drug and as a result we have almost no data about regular or long term use. I recall a post about a regular user who was having serious verbal memory problems and had met someone else suffering the same. I've little doubt there are other negatives to such receptor downregulation.

Trust me man, I have direct experience with this type of receptor downregulation from 2C's and NBOMEs causing long-term tolerance and depression as well as just mental 'dullness' and much less sociability.

If you want more details I'll write but trust me this tolerance from (heavy) abuse of NBOMEs or phenethylamines in general is REALLY terrible and no one wants to go through it, trust me. You'll only acquire this type of tolerance tripping more than once per 10 days or so, but once you get it you wont be able to get a real trip for MONTHS so be careful! Use common sense guys!

Not to say binging is always bad, but you must do it appropriately. By binging I don't mean large doses, I just mean taking psychedelics a couple days in a row, however you will have to dose larger each time for the desired effects which means an even large increase in tolerance. If you decide to splurge with a phenethylamine take at least a 3 week break afterward.
Never take an nbome two days in a row or even redose more than a few times in one trip, you'll fuck your tolerance for a good little bit. If you try to take 25c the second day for example it seems to have no effects (when I finally did snort a large large amount with that kind of tolerance the only effect I got was the most detailed and vivid and beautiful CEVs I have ever seen, but literally nothing else except maybe some stimulation, no trip at all)

In my experience 25C causes much more tolerance than 25I, but 25I will still fuck it all up.

So being my first time, i should take 500mcg blotter subling then? It seems like most ppl are talking no more than 500 up the nose or vaped.

I dont like sub, too hard to dose properly with such a fast acting and potent substance. You either get too little or too much a lot of times. With smoking or snorting it's much easier to titrate and dose safely. If someone disagrees with this I can go further into detail. remember to use liquid measurement when snorting, eyeballing is extremely dangerous.
 
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Never take an nbome two days in a row or even redose more than a few times in one trip, you'll fuck your tolerance for a good little bit. If you try to take 25c the second day for example it seems to have no effects

I've dosed 25C the day after my first time and got 60% the effects. Then after dosing it for four days straight, I took a five day break, dosed again and achieved 80% effects.

However, I'm concerned about an incident that may or may not regard 25C that occurred a few days ago. Taking a five day break from 25C prior to this, I dosed about 1.2mg over the course of a night. By the time the sun came up I was still tripping but was so tired and zombified it was no longer fun. I decided to sleep but sleep did not come easy. Eight hours later I woke up feeling a bit drained. I bought some cannabis, smoked it and felt fine. I smoked a little more and started to get a headache/migraine which almost never happens to me. By the end of the evening I was running a fever which forced me to take a NSAID and take a cold shower. Over the next few days I did not come down with a flu or illness, so I'm confused as to what happened. I slept 16 hours and was fine the next day, and smoking more of the same cannabis did not lead to another headache.

And what of that pesky chlorine in 25C? What becomes of it during metabolism? I am to understand the mere presence of an element is not necessarily a cause for concern, but does anyone have any leads or sources on how this compound is metabolized and removed from the body?
 
The miniscule dose of 25C makes the presence of chlorine irrelevant. It is possible that there are dangerous metabolites, but the most likely path is N-dealkylation to 2C-C which is known to be safe.

I couldn't tell you exactly what caused your side effects, but I bet you it's related to the fact that you've been dosing large doses with high frequency. The NBOMes are very forgiving in the short term, but if you do not respect them it appears that there are serious consequences. I suggest you use once every two weeks at the very most.
 
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