The Big and Dandy DMT thread - Next Phase

[Xorkoth]

Youkai, you might end up regretting all that MDMA, buddy. Maybe not now, but later. I've practically never used it compared to you, but I still regret having done it the last few times... aside from Coricidin it's the only drug regret I have. I feel like it changed my neurochemistry pretty significantly... there's something in there that didn't used to be. Maybe it's because it was the only time I ever experienced true black depression, and it's just a remnant of that. But I do know that other drugs do not affect me quite the same anymore.

 

[Ptah]

I know when its time to quit

To be honest, I do not believe you do. Be careful.

 

[Youkai]

Yeah, but Im suffering no ill effects from it, no depression, no brain dead feeling, no loss of memory/sentence structure. Actualy Im pretty elivated the rest of teh week in mood and seem to have pretty good memory, it also has made me not interested in lesser drugs such as opiates as I "get my fix" epr say durring the weekend. I ahev teh best intentions and so far so good. Its that damn mda that usualy has left me frazzled for a day or two after. As Is aid, in the past, my body and mind has told me when its time to put it away, and this message ha not been sent nor recieved yet.


Also, Iv never suffered real depression from MDMA use, maybe when I used to take gobs of it the next few days I would feel kinda bland, but honestly most of the time I am able to reflect on the experience and almost bring back that rushings ensation of bliss.

 

[Beenhead]

I find LSD/Nitrous more similar to salvia, in that the dissociativeeffects are pronounced moreso. Whats ya new tablet?

I got a new computer that you write on the screen with a stylus, it has to learn your handwriting

Youkai, I have rolled many many times in the past and only twice in the last 4 years. Trust me completely like people trust you when you talk about DMT when I say be careful with MDMA and takes long breaks. When you use it enough and you will the negative effects will start to creep in, and it is inevitable.

 

[Youkai]

Youkai, I have rolled many many times in the past and only twice in the last 4 years. Trust me completely like people trust you when you talk about DMT when I say be careful with MDMA and takes long breaks. When you use it enough and you will the negative effects will start to creep in, and it is inevitable.

Im still candyflipping this weekend to great live music and blasting to the cosmos of the inner most corners of the universal mind. I think it's the DMT that has been so forgiving to me with my MDMA use, kinda a reset of negitive side effects. MDMA is the material side, DMt is the thought side, together they can do no wrong!

 

[Xorkoth]

^^ I hope so. I wouldn't be shocked to learn that DMT could protect against things like that, but I'm not willing to bet it does. Just at least make sure you take breaks, man.

 

[Youkai]

^^ I hope so. I wouldn't be shocked to learn that DMT could protect against things like that, but I'm not willing to bet it does. Just at least make sure you take breaks, man.

That is an interesting theory, that DMT can protect against MDMA neurotoxicity.

Anyone know in detail the pharmacology of DMT? what all goes down physicaly when you smoke DMT in a suffiant dose.

 

[Beenhead]

Problems with MDMA result when the brain runs out of serotonin. Dopamine reuptake begins at the serotonin receptor and is long lasting. With such a short half-life of DMT in the brain, I cant imagine DMT Protecting senatonin receptors from reuptake of Dopamine.

I do think you have come along way since you came here Youkai, but just be careful, rolling is fun though! If you ever get the chance, listen to Keoki: Ego Trip. m awesome while Trolling. Anyone Pm me and I'll send it to you.

 

[Youkai]

HALLUCINOGENIC DRUGS OF THE INDOLEALKYLAMINE TYPE AND CENTRAL MONOAMINE NEURONS
NILS-ERIK ANDÉN 1, HANS CORRODI 1, and KJELL FUXE 1

1 Department of Pharmacology, University of Gothenburg; Biochemical Research Laboratories, Hässle, Ltd., Gothenburg; Department of Histology, Karolinska Institutet, Stockholm, Sweden

Combined histochemical and biochemical analysis revealed that psilocybin (5-50 mg/kg i.p.) and dimethyltryptamine (40-200 mg/kg i.p.) reduced the 5-hydroxytryptamine (5-HT) depletion in the brain and the spinal cord after amine synthesis inhibition, indicating reduced 5-HT turnover. This effect was not due to monoamine oxidase inhibition. The turnover of norepinephrine in the central nervous system was somewhat accelerated after the higher doses of psilocybin and dimethyltryptamine. In experiments on rat hindlimb reflexes, psilocybin (1-50 mg/kg i.p.) and N, N-dimethyltryptamine (10-50 mg/kg i.p.) caused changes similar to those seen after treatment with the 5-HT precursor 5-hydroxytryptophan, i.e., hyperextensions and athetoid movements. In this respect, tryptamine (50 mg/kg i.p.) was weakly effective and bufotenine (5-hydroxy-N, N-dimethyltryptamine) (50-100 mg/kg i.p.) was not effective. These findings indicate a 5-HT receptor stimulation by psilocybin and dimethyltryptamine in the same way as has previously been found for d-lysergic acid diethylamide (LSD), since the effects were independent of the known stores of 5-HT. The retardation of the 5-HT turnover after psilocybin and dimethyltryptamine may be caused by a negative feedback mechanism on the 5-HT neurons induced by the 5-HT receptor stimulation./QUOTE]

http://www.behaviouralpharm.com/pt/...912vn4lgVRfVFpJT!1105064230!181195628!8091!-1 this looks of interest
http://www.sciencedirect.com/scienc...serid=10&md5=fdb5debfe98ebd1cfd87e132c8d533fb

 

[Beenhead]

it does not mention anything about 5-ht2a receptors taking up dopamine, but it is an extremely interesting article that sounds Similar to what were talking about.


I cant access those articles can you send them to me or post them , those Sound like what were looking for , kinda.

 

[Youkai]

I dont either. I honestly fell out of reading abstracts and other scientific papers on psychedelics. There is only one way to truely experience them.

 

[illusion25]

Tommorrow there will be a pharmashusca expedition involving 10-15 people.
Doses are going to be 50-80mg of DMT.
Will update as soon as time allows.....(time?)

 

[Jabberwocky]

^^ I hope so. I wouldn't be shocked to learn that DMT could protect against things like that, but I'm not willing to bet it does. Just at least make sure you take breaks, man.

Unfortunately combining DMT with MDMA most likely increases the neurotoxicity from MDMA by raising intercranial temperature (one route MDMA is theorized to cause damage)-

 

[Jabberwocky]

Tommorrow there will be a pharmashusca expedition involving 10-15 people.
Doses are going to be 50-80mg of DMT.
Will update as soon as time allows.....(time?)

Wow, illusion! this sounds awesome!

This might be a great opportunity for a really interesting collaborative reports! (a bit selfish on my part since I lvoe reading collaborative TRs)-

peas and love and have a great blastoff!
S_S

 

[Youkai]

Unfortunately combining DMT with MDMA most likely increases the neurotoxicity from MDMA by raising intercranial temperature (one route MDMA is theorized to cause damage)-

My brain neverr feels hot.. and I thought MDMA was neurotoxitc because of free radicals formed as metablites causing mutant neurotransmitters to be taken into the cells.

 

[Jabberwocky]

There are several theories proposed for MDMA's neurotoxicity - none of them (as far as I know) are exclusive (meaning it could be be the case that both raised intercranial temps and reuptake of dopamine through serotonin channels causes neurotoxicity)-

the jury is decidely out on the MDMA neurotoxicity issue (although I'm sure the US gov would love for the data to come in so they could clamp down even harder on fun lovin' peeps who just want to roll every once in awhile)-

MDMA is probably much more toxic if its taken at abuse levels (what I would define as more than once a month) -

It takes probably 4-6 weeks for everything to normalize-

If you take it in the refractory period, you are likely causing more dopamine to be taken up through serotonin neurons than you would had your serootnin levels been normal-

Lastly, just because you don't feel something, does not mean that it is not going on in your brain - there is good reason why certain aspects of mental and physical processes in your brain are 'closed' to you (that is, you have no reason to be an accurate judge of your intercranial temp normally - MDMA neurotoxicity notwithstanding)-

take care,
S_S

 

[Beenhead]

I also read the article about MDMA induced neurotoxicity being exhaserbated by increased heat. Its not that your brain heats up or you feel your brain getting hotter, but an increase in the core body temperature.

 

[swilow]

Tommorrow there will be a pharmashusca expedition involving 10-15 people.
Doses are going to be 50-80mg of DMT.
Will update as soon as time allows.....(time?)

Enjoy

And why are we talking about MDMA ? Its a sucky drug really; Shulgins worst promotion I believe. His belief in MDMA actually makes me doubt a lot his views. MDMA will alsmot undoubtably lead to psychological depression the way your using it Youkai- especially as you've spoken about fellin the blues before. Hye, why am I am know talking about MDMA? Just be wise- DMT whilst loving, may choose to be unforgiving if your fucking up, as well you should know. Peace

Beenhead, I seriosuly thought you meant new tablet/pill/drug and were essentially fucked out of your head I was like "aoristic"- even Youkai himself couldn't have invented a weirder word.

 

[swilow]

I also read the article about MDMA induced neurotoxicity being exhaserbated by increased heat. Its not that your brain heats up or you feel your brain getting hotter, but an increase in the core body temperature.

A benzodiazepine could help counteract that; is that not one of their major physical effects? Sorry if wrong.

DMT just to stay ontopic

 

[Jabberwocky]

I dont know why but the pharmacodynamics of MDxx get REALLY fun to talk about after one has stopped doing them

I think MDMA should be used twice or thrice, integrated, and one should move on to the deeper psychedelics such as LSD, DMT, or mushrooms-

anyways! off to sniffle some ketamittles!