^ people a lot smarter than you & I, with many advanced degrees, are working on that as we speak. LSD's precise mechanism of action is unknown. Suffice to say it's pretty darn complicated. LSD works on a wide variety of neurotransmitters, serotonin being the primary one. Beyond that, if you have to ask, it's over your head, sorry, not trying to be rude. A lot of it's over my head too.