The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

[TheAppleCore]

Cross post:

http://www.bluelight.org/vb/threads...cPT-Thread?p=13828100&viewfull=1#post13828100


Also, while I'm at it, allow me to ask a n00b question. Are substitutions in the amino group in tryptamine symmetrical, in the sense that methyl-ethyl-tryptamine is identical to ethyl-methyl-tryptamine?

 

[BobbyDick]

What is downstream of every single muscarinic receptor?

 

[Nagelfar]

The last molecule you displayed is an ether, not an ester, so esterases cannot separate the 2 molecules. The P450 system probably wouldn't be able to either.

With the 6-position substitution place ethers (at least short ethers that don't displace the rest of the fit of the morphine derivative from the mu-receptor site) as shown, it doesn't need to be cleaved to be active, check out heterocodeine.

The bentley compounds have alcohols at the 7 position (7 alpha-oriented), so having a menthol which is a complex alcohol as an ether on the 6 position with one of those would be interesting, wonder if it'd fit into both mu sites & TRPM8 receptor sites, and how it would attenuate kappa opioid receptors since menthol affects that too.

 

[sekio]

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