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The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

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Getting 4-ho-DPT fumerate into solution for IMing

I believe this is the thread I said I would post back to months ago after I agreed to act on Sekio’s sage advice to just try “boiling the hell out of it” to get 4-ho-DPT fumerate in solution for IMing. It mostly worked. I could have easily got the 35mg in 2 mL but I wanted to see how far intense boiling in 90 units (0.9 ML) of sterile water and 10 units of 5% acetic acid could take it.

I put it in a tall test tube so it could boil violently without leaping out, and set the tube’s screw cap on top so that pressure could escape while confining a significant portion of the vapor to the tube. I started using my microwave’s lowest defrost setting (the tube is plastic). The longest I let it go for was 30 seconds straight. This got most of it into solution but I set it to full power to see what would happen. I boiled a little too long and, after spinning around in my living room like a lunatic with the tube at arm’s length to get the droplets condensed on the side to pool at the bottom, dumping it into a vial, and drawing the solution into a syringe, I found I had boiled off 40 units leaving 60 units 4-ho-DPT solution. I didn’t go through the work of properly quantifying what was left because I was burning daylight and had a nature-gasmic adventure in recreational drug abuse to get under way but after drying it out with a hair dryer it looked like maybe 5 mg was left. I dumped some vodka on it and swallowed it for what it was worth.

Judging by the subjective effects of the estimated 30 mg IM dose, IMing is an improvement in potency above insufflation of maybe 70 percent. Also, like DPT, the qualitative effects significantly benefit from the “hit me fast and all in one go” onset of IM administration over insufflation. I find 4-ho-DPT to have proportionally less ego dissolving and more sensuous, aesthetic-enhancing, and synaesthetic effects than DPT while maintaining some essential qualities (it’s closer to DPT than anything else, and I’ve tried over 15 5-HT psychedelics, including 4-ho-MPT, which is probably the next closest in my experience). I’ll probably use two or maybe even three 1 mL syringes next time to do a proper strong dose of 50 to 60 mg. I’m fairly confident from my 55 mg insufflated experience in the past that this dose IM’d will be enough to maximize 4-ho-DPT’s novel beneficial effects without venturing into ego death territory, which can get confusing and more difficult to integrate in a psychologically practical way (at this point of my psychedelic career I’m finding it more productive and prone to to novel discovery to push experience within dissolved but not totally “de-patterned” ego boundaries).
 
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I believe this is the thread I said I would post back to months ago after I agreed to act on Sekio’s sage advice to just try “boiling the hell out of it” to get 4-ho-DPT fumerate in solution for IMing. It mostly worked. I could have easily got the 35mg in 2 mL but I wanted to see how far intense boiling in 90 units (0.9 ML) of sterile water and 10 units of 5% acetic acid could take it.

I put it in a tall test tube so it could boil violently without leaping out, and set the tube’s screw cap on top so that pressure could escape while confining a significant portion of the vapor to the tube. I started using my microwave’s lowest defrost setting (the tube is plastic). The longest I let it go for was 30 seconds straight. This got most of it into solution but I set it to full power to see what would happen. I boiled a little too long and, after spinning around in my living room like a lunatic with the tube at arm’s length to get the droplets condensed on the side to pool at the bottom, dumping it into a vial, and drawing the solution into a syringe, I found I had boiled off 40 units leaving 60 units 4-ho-DPT solution. I didn’t go through the work of properly quantifying what was left because I was burning daylight and had a nature-gasmic adventure in recreational drug abuse to get under way but after drying it out with a hair dryer it looked like maybe 5 mg was left. I dumped some vodka on it and swallowed it for what it was worth.

Judging by the subjective effects of the estimated 30 mg IM dose, IMing is an improvement in potency above insufflation of maybe 70 percent. Also, like DPT, the qualitative effects significantly benefit from the “hit me fast and all in one go” onset of IM administration over insufflation. I find 4-ho-DPT to have proportionally less ego dissolving and more sensuous, aesthetic-enhancing, and synaesthetic effects than DPT while maintaining some essential qualities (it’s closer to DPT than anything else, and I’ve tried over 15 5-HT psychedelics, including 4-ho-MPT, which is probably the next closest in my experience). I’ll probably use two or maybe even three 1 mL syringes next time to do a proper strong dose of 50 to 60 mg. I’m fairly confident from my 55 mg insufflated experience in the past that this dose IM’d will be enough to maximize 4-ho-DPT’s novel beneficial effects without venturing into ego death territory, which can get confusing and more difficult to integrate in a psychologically practical way (at this point of my psychedelic career I’m finding it more productive and prone to to novel discovery to push experience within dissolved but not totally “de-patterned” ego boundaries).
^I have to partially rescind/qualify this: I've since tried to get 50 mg in what was originally 2 mL by hard boiling in 9:1 water:5% acetic acid. I boiled it down to 0.7 mL and the solution was clear, but clearly too concentrated because after I drew it up into the syringe it returned to room temperature and crystals started precipitating out of the solution, which clogged the syringe. Due to time constraints and predicted weather this lead to me simply plugging the whole mess, which isn't as potent an ROA as insufflation for this compound, FYI. I can't raise the acidity too much because I want to IM it, and I prefer to IM as little volume as possible. Next time I may try citric acid monohydrate in the hope it will be better at keeping 4-ho-DPT fumerate in solution than acetic acid. I'll probably also start off with 3.5-ish mL of acid/water solution in expectation of boiling it down to ~2mL. I also recommend using a proper boiling test tube and flame rather than a damned microwave -- the rate of heating is just not controllable enough (might need to get that before this is over).
 
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SSRIs, most likely, although I'm not sure how true this is in non-impaired models. Amitriptyline is also a TrkB receptor agonist, so it probably has similar properties to BDNF in that regard.

re: amphetamine, I'd assume so.
 
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Yet at the cost of cognition. I seem to remember that in some respects 'helpful' doses of nmda antagonists are also harmful to the brain.
 
What about things like tianeptine? AFAIK that doesn't impair cognition despite NMDA antagonism.
 
alleviating the aches and tension from normal recreational doses of vasoconstricting psychedelics like LSD

Magnesium supplements have been known to relieve muscle tension on psychedelics / empathogens / stimulants. (Needs to be an effective source - magnesium oxide is absorbed very poorly, in particular.)
 
Anyone aware of a barbiturate binding site?

I am aware of the BZP binding site at GABAA. Is there any binding sites known for barbiturates, aside from them merely having the general effect of positively allosteric modulating GABAA receptors?? ...like some anticonvulsants & most GABAergics (excluding GABAB) agonists?


I am just wondering since i take high doses of butalbital (an intermediate-acting-barbiturate),,,,,,


If anyone has any sources w/ any responses along w/ their posts.. please post them as well!! B/c I couldn't find them via google
 
Yes, there is a distinct barbiturate binding site on the GABAA receptor complex (I believe localized to the beta subunits). This is part of the reason why barbiturates cause qualitatively different allosteric modulation from benzodiazepines.

ebola
 
This is totally not helpful, but I had it sitting around, so whatever. Will look for a more useful picture/data later.

cc6150-1_zps0d47814a.jpg
 
Sooo I'm really really fond of aniracetam, which unlike the many other nootropics I've tried seems to have incredible effects on my concentration & memory and a very uplifting effect on my mood.
Anyway, I've recently gotten myself some theanine which I take occasionally for it's calming effect.

I know you ADD's love vague speculative questions so:
Aniracetam is purported to act on the AMPAr as a positive allosteric modulator, which could go some way to explain its nootropic effect.
Theanine also acts on AMPA but seems to act as an antagonist, from what I've read?

Could theanine be working against the nice effects I get from aniracetam?
 

Well yeah, but god forbid someone actually enjoy a medication that they're taking. We obviously can't have that.

Anxiety? Have some SSRIs!

I'm not bitter I swear.
 
How is percent THC determined for a given strain of cannabis? More specifically, what does that refer to? If I smoke a gram of 30% THC weed, am I ingesting 300 mg of THC?
 
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