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The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

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It's not about any particular drug, so I hope I'm not asking in a wrong place.

For the activation of NMDA receptor by glutamate, co-stimulation by glycine or D-serine is required. Are co-ligands also required for exogenous agonists to exert their action (they should either bind to the glutamate site or glycine site and require co-stimulation in the other site... or not?)?
 
Mandark said:
It's not about any particular drug, so I hope I'm not asking in a wrong place.

For the activation of NMDA receptor by glutamate, co-stimulation by glycine or D-serine is required. Are co-ligands also required for exogenous agonists to exert their action (they should either bind to the glutamate site or glycine site and require co-stimulation in the other site... or not?)?
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I can't think of any exogenous NMDA receptor agonists off the top of my head, are you thinking of one in particular?

Most recreational drugs that act at NMDA are antagonists (ketamine, MXE, DXM, etc.) and don't require co-ligands to block receptor activation.
 
NSFW:
420px-NMDA_receptor_activation_and_antagonists.PNG


Agonists at the glycine/kainate site do require a co-agonist to achieve receptor activation. There do exist synthetic exogenous NMDA agonists, e.g. NMDA itself (I think it's exogenous), tetrazolylglycine, some aminophosphonates I think... but they are not used in vivo because they are considered to be excitotoxins.

Most "NMDA antagonists" are really uncompetitive channel blockers (ketamine, MXE, DXM)
 
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endotropic said:
I can't think of any exogenous NMDA receptor agonists off the top of my head, are you thinking of one in particular?
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Not really, Wikipedia mentions some (like quinolinate, and obviously NMDA) but my question arose from general curiosity.
 
Mandark said:
Not really, Wikipedia mentions some (like quinolinate, and obviously NMDA) but my question arose from general curiosity.
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The reason I asked (and I should have mentioned this in my original post) is that for a receptor like NMDA with multiple binding sites the answer to your question could depend on which site the agonist binds to, but I think sekio answered your question already so I'll leave it at that.
 
Ho-Chi-Minh said:
They cancel each other out to an extent though, or at least morphine decreases endogenous norepinepherine levels throughout the brain.
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That may be true, but your logic doesn't quite fit. There's no reason that decreasing endogenous norepinephrine would decrease the effects of exogenous epinephrine, considering epinephrine binds adrenergic receptors directly and doesn't depend on norepinephrine to produce its effects.
 
epinepherine and norepinepherine the same I meant, sorry

regardless in terms of subjective and objective effects the result would be partial negation right?
 
asked over in the buphedrone megathread in OD but no response so far

any speculation as to the shelf-life of buphedrone?

395px-Buphedrone.svg.png


pretty sure it was the hcl salt
 
Depending on how it's stored, probably 6 months* to 2 years, or more? Cathinones are fairly stable if kept dry, but can cleave to an amine and benzaldehyde if stored improperly (moisture, heat, acid). The primary amines like cathinone are the worst.

Keep it dry and out of bright light and it should stay good for a couple of years at least.

* Tocris Bioscience suggests a minimum 6 month shelf life for mephedrone at room temperature.
 
hm this sample i have is approaching 2 years old. has a bit of a funny smell to it now, but i don't remember what it smelled like when i first got it. perhaps i should just toss it.
 
Most of the cathinones smell wierd if they're impure or have degraded even a small amount. Fishy/sperm smells (amines) or almond/pistachio type smells (benzaldehydes) especially.
 
That's probably methylamine from degradation/hydrolysis of the amine. But it could also be left over from synthesis. Either way, if the compound is still a white to off-white crystalline powder it's probably fine.
 
I'm not toally sure I'm allowed to ask this question, or if it's even advanced enough, but here goes....

If I have an equal mixture of 2 compounds as powder, naproxen and carisoprodol, one being "practically insoluble in water" (the naproxen) and the other "slightly soluble in water" (the soma), according to wiki.
Wouldn't it be possible for me to just dissolve it in water, apply stirring and slight heat (steam bath), and then run it through a coffee filter?

My therory: the naproxen should stay a solid and thus get stuck in the coffe filter, while the soma should dissolve in the water and run through the coffe filter. Right?
 
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