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The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

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Post it to imgur or something. This isn't advanced though, so I'll move it to the big and banging thread
 
After long-term(~1 year) of inappropriate MXE storage, could it produce/transfrom something more toxic then plain mxe?
 
Morkin said:
Hi - I bought two things which arrived unlabelled except for images of the chemical structure. I've forgotten what I ordered and the vendor keeps no purchasing history, nor do they detail your purchase in the email. Google image search is getting me nothing but IKEA instructions LOL

How do I upload images here or direct them to an outside link? I need help id-ing these chemical structures.

Cheers!
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tinypic.com is a great place to upload images imo
 
^ thanks

Ok, I ID'd one of them, but what is this?

jf8a5w.jpg
 
Hey, very basic question here, I hope it's okay.

2 ways of describing the same molecule:
2,5-DIMETHOXY-3,4-(TRIMETHYLENE)PHENETHYLAMINE
and
5-(2-AMINOETHYL)-4,7-DIMETHOXYINDANE)

first one is IUPAC, right? What is the second naming system called and were can I read about it?
 
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I've read conflicting reports. In low doses (~15-20mg) does amphetamine cause the release and re-uptake of serotonin. How about increasing extracellular concentrations through monoamine oxidase inhibition? Sek told me in only high doses, but at least initial anecdotal reports of low-dose amphetamine seem to suggest otherwise.
 
sekio said:
2nd one is IUPAC. Some people "corrupt" IUPAC naming by giving "technically correct: structure names.
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I get it now. The first one is kind of an abbreviation, in a way. An the second one is the right IUPAC.

Thanks, sekio. you're a sport.

Cheerio
 
After using a DRI, will the dopamine remain in the synaptic cleft until the DAT isn't blocked anymore or will it be broken down before that?
 
Sek told me in only high doses, but at least initial anecdotal reports of low-dose amphetamine seem to suggest otherwise.
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No, anecdotal reports cannot speak to such matters even in principle.

After using a DRI, will the dopamine remain in the synaptic cleft until the DAT isn't blocked anymore or will it be broken down before that?
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MAO catabolizes intersynaptic dopamine.

ebola
 
Quick L-Tyrosine question

I have 750mg Capsules of L-Tyrosine, I've read that in order for it to actually be absorbed I need Vitamin B-6 also. It's hard to find just Vitamin B6, but I did find this product which contains 25mg B-6 aswell as a ton of other things. Is 25mg enough to get the Tyrosine to do its job in the brain and produce more norepinephrine etc?

I've read you build a quick tolerance to any L-Tyrosine effects though (any idea how long???)

Also, how much of each should I take, at the same time, one before the other, empty stomach, with food, morning/night, etc

Any help would be appreciated. Basically I'm depressed and also trying to come off Benzos at the same time so I'm trying everything I can to improve my mood. I'm already on Effexor 225mg. I have in the past taken 5-HTP to try and improve my mood also, but I don't think it's such a good idea with the SNRI aswell, due to the risk of serotonin syndrome(right?)

Thanks in advance if anyone can help clear some of my questions up and/or explain why this might theoretically work (I've read some people think it's just placebo)
 
Take on an empty stomach with a multivitamin and a small amount of fruit (any low protein food works). Effectively you're just getting slightly more of an amino acid you should have anyways. Personally I found it worked ok for me for two weeks, granted this was coming from a allergic reaction to an antibiotic that left me unable to eat meat for a couple weeks. Don't get sucked into fancy combination products.

Best advice I can give you is go for a high protein diet and some long distance walks.
This isn't really advanced so I'll move it to the questions thread.
 
Epsilon Alpha said:
Take on an empty stomach with a multivitamin and a small amount of fruit (any low protein food works). Effectively you're just getting slightly more of an amino acid you should have anyways. Personally I found it worked ok for me for two weeks, granted this was coming from a allergic reaction to an antibiotic that left me unable to eat meat for a couple weeks. Don't get sucked into fancy combination products.

Best advice I can give you is go for a high protein diet and some long distance walks.
This isn't really advanced so I'll move it to the questions thread.
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Well the advanced bit is that i'm looking for information on how exactly this stuff works and effects the brain chemistry
 
Ah, well if you want a longer answer I'd be happy to oblige. Effectively tyrosine is the substrate right before the rate limiting step of dopamine and noradrenalin synthesis. Tyrosine hydroxylase is a tightly regulated enzyme, requiring among other things B6, tyrosine, and THB. It's activity can be increased by caffeine and nicotine, however chronically it's not significant.

Tyrosine hydroxylase produces L-dopa, which is decarboxylated by dopa decarboxylase (thing has like 10 frigging names), producing dopamine. Dopamine is hydroxylated by dopamine beta hydroxylase to produce noradrenalin.
 
Thanks for the reply. So if i'm reading this right, some L-tyrosine with B-6 to [...] will get me more L-dopa, in small amounts?

Wikipedia:
L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline)
Click to expand...

And if my depression/anxiety is due to low neurotransmitters it could theoretically help, along with my SNRI (Effexor)? According to wikipedia the best (only?) way for general public to get more dopamine in their system is this little tyrosine stack?

Wikipedia on Effexor:
At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission.
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So I'm on 225 so it's only affecting Serotonen and noradrenergic systems, (I can't get my doc to give me 300+ a day), the tyrosine stack could be a sort of replacement for that instead without having to up the Effexor dose? (It's not licensed here in the UK above 150mg for depression/anxiety, I was lucky to get 225mg after I told him about a suicide attempt)
 
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