Opioids the best potentiator for oxycodone

[sludgefactory101]

OK so i have searched through all the potentiation threads, but i want a definitive answer. what is the best thing to potentiate oxycodone with? i heard that doing the whole white grapefruit juice thing isnt good because it prevents it from turning into oxymorphone, but it only prevents it a little bit? Last night I took a good amount after potentiating and i feel like my high only lasted a little while compared to what it could have been. Also i use 25mg of diphenhydramine to potentiate my opiates. Should i just do the diphenhydramine and leave the white grapefruit juice alone?

 

[mrflowers00]

oxycodone doesn't turn into oxymorphone they are synthesized from two different chemicals

 

[SPDemon420]

^ it does actually - oxycodone breaks down into metabolites noroxycodone and oxymorphone in your body.

 

[sludgefactory101]

So what is the best? I also have tagamet. Should i try tagamet and benadryl? or stick with the juice and benadryl?

 

[Coraline]

I would try Tagamet 30-45 min before the dose. It worked for me while taking norco. It keeps liver receptors busy and your blood plasm levels of the opiate last longer.

 

[mrflowers00]

how does it break down into oxymorphone if they aren't derived from the same chemical

 

[Morphling]

Via P450 2D6?

 

[DooMMooD]

DXM hands down the best if you are only going to get one.

Then tie for 2nd of tag & benadryl.

I ALWAYS took those 3. But if i could only get my hands on 1? DXM easily. Gives the most 'bang for your potentiaton buck'

 

[sekio]

Don't know how far into synthesis it's polite to go, but.

I would bet good money that oxymorphone is actually produced industrially from... (drumroll) demethylation of oxycodone. Oxycodone is produced from a variety of sources but industrially is derived from thebaine.

... given 63% yield and the fact that oxymorphone is roughly 15x stronger than the methyl ether oxycodone, you have around 9 times more opioid activity after conversion

I would imagine that these yields would be substantially better in the top secret pharma procedures.

Oxycodone is indeed demethylated to oxymorphone in vivo, but not nearly as much as codeine I don't think.

As for OP - drugs like marijuana/sedative antihistamines will generally potentiate the sedative effects (make it "feel stronger"). Tagamet and other enzyme inhibitors (and to some extent other substrates of metabolic enzymes like DXM and codeine) will make it last longer but may actually make it slightly less potent by retarding the formation of oxymorphone in the liver.

Generally a "good dose" is 25-50mg promethazine or diphenhydramine, 50-100mg dimenhydrinate, or 10-25 mg hydroxyzine. Doses of DXM for potentiation are generally between 30 and 300mg depending how "psychedelic" you want it to be

I couldn't tell you about doses of Tagamet.

 

[sludgefactory101]

thanks everybody for the replies. I think tonight im going to just use some benadryl, then next time i do it ill try both benadryl and tag, then try dxm.

 

[HCandKROD]

Tagamet and Benadryl

 

[DooMMooD]

I just think DXM think it makes you nod harder/more frequently, that it makes the high longer, and just increased in every way possible. Just my 2 cents, but take it for what its worth. plus: it helps slow down tolerance build up. particularly important if you do a lot of opiates and just took a day or two off. helps you get that extra bit in before your back to where you were.

Honestly I used to take all 3:

tagamet 600mg (though if youre bigger i say 750mg) 45 minutes prior

benadryl 50-75mg 15-20 minutes prior

DXM recommended dosage on bottle, 15-20 minutes prior

i never did it any other way. Unless, of course, i was lacking them.

Dosing tag 1 time per day is enough IME no matter how many times you redose opiates So don't take anymore than that. Taking too much tag will make you sick. Realllllll sick. I mean really really really sick. It will feel like dwarves are hammering away inside your skull, as you vomit violently on whatever happens to be in front of you. All fucking day.

 

[rainbowzebra420]

dxm IME.

 

[jakejake678]

IMO hydroxyzine has always made it more sedative/noddy if thats what your looking for. cimetide (Tagamet) also is very good for opiate or even benzo potentiation. i know this is a harm reduction site and mixing downers is a big no-no, if you keep the opiate dosages as low as possiable opiates + benzo's has been a fun one for me. just keep the doages real low and slowly work your way up.

 

[sludgefactory101]

well last night i tried just the benadryl and oxy. was nice but my high only lasted like an hour or so, which was weird. so tomorrow night or sunday night i will try dxm. then later try tagemet and benadryl.

 

[LOGan1314]

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