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Benzos The Benzodiazepine MEGA THREAD - Direct Benzo Questions Here

Yes it safe with to take olanazipine with sparing amounts of phenibut, I was actually prescribed to it and my doc recommended phenibut. Why would you want to take piracetam with the two other drugs though?
Also olanazipine is a theinodiazepine, it acts primarily as a benzo-esque anti-psychotic. Not a very euphoric drug IME. It has a lot of negative effects as well.
 
I currently take Piracetam because i've found it's helped alot with the side effects of Xanax. Will Phenibut effect my benzo tolerance? I'm not looking for any euphoria from the Zyprexa, I was prescribed it for panic attacks, anxiety, paranoia, etc etc etc etc
 
Yes it will affect your GABA tolerance. It is structurally related and designed to work with a similar mehanism as GABA and voltage gated ion channels. Anyone can feel free to correct me on that though.
To sum it up, you will want to take each drug in moderation as respiratory depression may occur at higher doses and you don't have experience with this particular combination. Piracetam is an allosteric modulator of AMPA and also works as an agonist on acetylcholine. I am just going from memory on that one though.
 
Oh ok, thanks. I suppose there's no point taking Phenibut as my xanax tolerance is through the roof. Id probably need 20grams of Phenibut to even feel anything. Then id need even more xanax to feel anything if Phenibut effects my xanax tolerance, lol
 
You might as well save your money then. I found phenibut to be subpar, especially when you have benzo tolerence. How is the piracetam with the alprazolam? I used to take choline with my clonazepam but never really found enough positive effects to outweigh the discomfort it gave me.
 
entheo said:
I was prescribed to temazepam for awhile, at 30 mg capsules, but I could take 90-120mgs a night with a small 2 mg dose of clonazepam and still not fall asleep. I found temazepam to be enjoyable but it didn't have the hypnotic effects I need. Even my normal 5 mg of clonazepam with 350 mg soma and 1750 mg of gabapentin is just relaxing. Triazolam is awesome for getting me to sleep but I'll wake up 2-3 hours after taking it. I still have yet to found an effective hypnotic. I always run out of my script early because I end up taking a lot more clonazepam than prescribed.
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Yeah I'm also prescribed the 30mg temazepams, they can't be beat IMO.

Regarding the clonazepam, why do you think that is? IME clonazepam is a really inferior benzodiazepine, it's really weak. It looks great on paper, it's potent, a good anticonvulsant, supposedly good for a lot of other things too but I never got those benefits. To me it was a horrible anxiolytic, it just didn't work for anxiety, at all. I could never even think of using it as a hypnotic either. I'm not sure my body could distinguish it from a breath mint.

Do you end up taking more klonopin because you find it doesn't work well? 5mg is a larger dose than most are prescribed, how often do you need to take more than 5mg? 5mg of klonopin to me feels weaker than 0.5mg alprazolam.

It's really crazy sometimes just how different people's bodies are, YMMV etc.
 
Piracetam has helped ALOT with memory, speech (words come out more fluently without having to think of the word because of Alprazolam) I thought I was permanently fried from Alprazolam & didn't even think Piracetam would work while taking Alprazolam but it has helped ALOT! I know if i can quit Alprazolam (which i know is holding the Piracetam's effects back to an extent) i'll be flying
 
Some how while on a couple of etizolams and about 6 drinks on saturday night I blacked out and after leaving a club to go to a hotel with some friends and attractive girls I managed to have my pants fall or so I've been told and it took me a solid 3 seconds to gain my balance to pull them back up lol.

I don't remember where the line went from me feeling stone sober to suddenly blacking out, when I got to the club I felt fine though almost completely sober and only had a few more drinks. Assuming the etizolam likely hadn't kicked in yet, I took it sublingually but I swallowed after only a few mins. I took 2 I believe.
 
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Tricomb- I usually end up going for about 8 mgs 3-4 nights a week. Alprazolam actually worked better as far as a hypnotic, but it makes me very reckless. I just does not agree with me, paradoxical reactions out the wazu. Clonazepam just has a certain feeling that I have come to associate with relief and mental peace. It's not 'fun' but it does the job of taking my anxiety away, especially when I take it sublingually. I have yet to find a hypnotic that works for me, even after years of therapy and multiple sleep studies. It's rather debilitating actually.

As far as piracetam is concerned, I'm very happy that it helped you. I was actually looking for the same results with choline but I take too many psychoactives and fitness supplements. It made me feel wired and very uncomfortable.
 
Do benzos have mechanism of action other than as a GABA modulator?

I'm wondering why the list shows different therapeutic use if the mechanism is similar or identical.
 
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One of Valerians main mechanisms works as a benzodiazepine does but to achieve a benzodiazepine-like effect one would have to take a large amount of Valerian. I was swallowing about 1 cup (with water) twice a day to get significant relief. Inability to accurately control my dosage and a short half-life made me switch to a pharmacuetical.
 
I use valerian extract capsules- I'm not sure about the dosage of each alkaloid though. It really doesn't do too muh for me besides help me cut my benzo dose by a tiny fraction, or help me barely get through the withdrawals. It's not going rk be overwhelming or able to completely replaces benzos at any level but you might as well add some to your stash if you want a little something extra.
 
I've gone as high as 20x of the large capsules of standardized valerian root extract in orange juice* on an empty stomach. At best I find it as a mild and short-lived intoxicant with minimal anxiolytic or hypnotic effects. However there is in my experience some synergy with OTC antihistamine diphenhydramine when used for sleep.

*not sure why but it does better for me in juice rather than than water. Acid or enzyme reaction maybe. Kills the taste too :-)
 
^ yeah valerian has a very offputting odor IMO. I find it's only a good replacement for benzos if you have little-no tolerance. Other than that it just help my wd when I take them with my tapering doses.

I'm going to the doc tomorrow, 5mg clonazepam still hasn't ant working for my insomnia. I need to change meds and get back to my pre- taper doses (or an equivelant) I just don't know how to convince my psych that I can't taper from kpins when they don't even do the job they ate rx'ed for.
 
How much of a potentiator is Tagamet for Alprazolam? eg. If I take 6mg Alprazolam how much less Alprazolam would i need if I took the Tagamet?
Tried Grapefruit juice & it did potentiate it but it was alot more sedated, sleepy. Is this the case with Tagamet?
 
Probably. 6mg is a lot. I'm just guessing but I would say if 6 mg is your normal tolerance then try 200mg Tagamet and 4mg Xanax. Maybe less. You could always take more Xanax later if you need to.
 
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