Fertile
Bluelighter
- Joined
- Mar 31, 2022
- Messages
- 1,627
Well Wikipedia gives a very good definition.
But put simply, it's the ratio of how soluble a compound is in water to how soluble it is in fat tissue.
So a compound has to have SOME water solubility so that it can be absorbed by the stomach, transported by the blood stream and transported into the. But important to remember that the brain is essentially fatty. That's why all psychoactive compounds have to have a LogP of 0.5-5.
It's worth reading about Lipinski's 'Rule of Five' which shows all the major factors that influence absorption, distribution and redistribution.
But 3.2 is quite high so MDMA is lipophilic.
But put simply, it's the ratio of how soluble a compound is in water to how soluble it is in fat tissue.
So a compound has to have SOME water solubility so that it can be absorbed by the stomach, transported by the blood stream and transported into the. But important to remember that the brain is essentially fatty. That's why all psychoactive compounds have to have a LogP of 0.5-5.
It's worth reading about Lipinski's 'Rule of Five' which shows all the major factors that influence absorption, distribution and redistribution.
But 3.2 is quite high so MDMA is lipophilic.