Terpene isolates

[Smags2.0]

Hello everyone, I’m trying to gather as much info as possible about pure, isolated terpenes while I wait on samples of beta Caryophyllene and Myrcene. The (very) tiny amount of reports I can find online seem to exceed my expectations in terms of effects. I even found one (will find again upon request) that claims IV administration of isolated caryophyllene resulted in anti inflammatory and analgesic effect similar to that of morphine.

Do any of you folks have experience with pure terpenes or any insight into pharmacology that would allow you to predict what they might do?

 

[Twisted_Chemist]

Take a look at this article, it's not super heavy reading and should hopefully help with some of your questions.



https://www.sciencedirect.com/science/article/abs/pii/S0223523418306408#:~:text=cannabis and hops.-,Terpenes' medicinal properties are supported by numerous in vitro, animal,-diabetic attributes, among others.

Edit: sorry was logged into my account, didn't realize this behind the paywall. If you really are interested in learning much more in-depths info, find away.

Otherwise Leafly has a page dedicated to terps that are found in the pot plant.

Terpenes

Terpenes are the aromatic compounds that give cannabis strains their unique scent. Learn more about terpenes from Leafly.

www.leafly.com

As far as pharmacology goes, there is still lots of research to be done and sadly it probably will be a while, most have little interest in studying them as lots of people think of essential oils as a homeopathic or similar type of treatment. For example, linalool is a terpene commonly found in lavender oil, which is touted for its calming, stress-relieving properties. It is also found in weed.

The big research on terps now is how they interact with CBD, THC and other cannabinoids.

I'm really high so sorry if my train of thought is off

 

[Smags2.0]

Hey there, I haven’t read the link yet, but wanted to thank you for your input! Also, I typed all of this up under the impression that you started a different thread, sooo while some of it might not track well, I do think it’s all still worth bringing up. Hopefully it can start the convo and reel in more folks with more knowledge like yourself.

I have several reasons to believe that there will be a bigger market for pure turpenes in the near future. The question is: what needs to happen first?

At the moment, it’s difficult to find even anecdotal evidence that pure terpenes have desirable effects—but the few reports out there seem to exceed my personal expectations. Also, there’s at least one paper published that supports beta caryophyllene’s anti inflammatory and analgesic effects.

What we need first and foremost (imo) is more experience reports to support the claim that isolated terpenes each have their own benefits. I should have my first sample of beta caryophyllene and Limonene by this weekend, and I will post what I find regarding oral admin of each, vaporization of each, mixture with HHC or THC gummies, and mixture with flower. I’m not a huge weed smoker, so I won’t be mixing it with any concentrated or dabs as many folks have suggested.

Anyways, that’s where I’m at in my research.. I look forward to learning with you!

 

[Smags2.0]

Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A2A Receptors

Terpenes are small hydrocarbon compounds that impart aroma and taste to many plants, including Cannabis sativa. A number of studies have shown that terpenes can produce pain relief in various pain states in both humans and animals. However, these studies ...

www.ncbi.nlm.nih.gov

 

[emkee_reinvented]

Mycrene was rumored to enhance the high, guess mango contains to little for noticeable effects.

This might interest you, dont know if its science or fiction. But about Terpenes/ Terpenoids.

https://cannabis.net/blog/smoke/terpenes-that-amplify-your-high

 

[Didgital]

It’s difficult to find even anecdotal evidence that pure terpenes have desirable effects

I would agree, tho I do know people that have dabbed pure terms just to get an understanding of individual flavors. I never really heard they were psychoactive aside a solvent woozy feeling.

I have always thought that while terps may be somewhat bioactive, I tend to dismiss the idea that they cause significant entourage effects to augment the THC high. I'm quite the skeptic, but I've also done quite a bit of work isolating terps. I once had 2 fractions and each smelled good separately, and I figured I'd add them back together, redistill for let's say 4 fractions. It totally smelled like shit after I remixed them. Terpinolene is my personal fav.

claims IV administration of isolated caryophyllene resulted in anti inflammatory and analgesic effect similar to that of morphine.

If true that's fascinating.