Temazepam's receptor affinities

[Black Octagon]

I know this isn't quite the right forum for this, but I am a little frustrated because when I asked this question in Drug Basics I got exactly zero responses. Delete at will if you must.

I just want to know if temazepam is a 5HT2a antagonist. Real basic I know, but I have no training in chemistry or pharmacology and so was unable to make much sense of the technical papers which Google had to offer.

Thanks.

 

[jasoncrest]

I don't know why Temazepam would be a 5-HT2 antagonist...
It's a benzo, and binds to benzo receprors...

 

[BilZ0r]

I think it's selective for the benzo receptor in its various forms... I can't find anything to say otherwise... Link us to these papers that confuse you, so we can help you through them...

 

[Black Octagon]

I can't find the specific paper right now, but it was about an experiment in which a subject was administered with temazepam and then a specific 5HT2a antagonist. One of the paper's conclusions was that the 5HT2a antagonist seemed to increase some of temazepam's effects, which got me wondering if temazepam itself has any similar receptor affinity.

But I'm more than likely reading this completely wrong.

 

[yaesutom]

Hmm well all I will add, is - Nitrazepam, that stuff... i've tried probably most of the benzo's, not the roofies one, probably most others though.

But when i'd take nitrazepam, i'd always get color enhancement, it was always noticeable, caught my attention. It wouldn't catch most people's attention though, but that benzo always felt different (i really loved it actually, the duration was short though - and i always needed a bigger dose more like 30-40mg, other than the feel good part though (benzo's really don't usualy 'feel good' at all) the color enhancement, felt like it was hitting some receptors (more benzo receptors? i dunno) that the other benzo's just didnt hit.

 

[BilZ0r]

Well the GABA-A receptor (which is where the benzoreceptor is) comes in all different flavors depending on which of the 20 or so, subunits make up the GABA-A receptor. Different benzos should have affinity for GABA-A receptors made with different subunits (as discussed in this thread). That's far more likely to explain the differences in difference benzos than any 5-HT2 receptor affinities.

 

[Black Octagon]

Thanks guys. That clears things up perfectly.

 

[5-HT2]

I think that paper was referring to indirect circuit-based effects. Ergo, blocking tonic 5-HT2A receptor activation somehow causes an increase in GABA release, or in modulation of the GABA-A receptor by intra- or extra- cellular factors, thereby increasing the effects of temazepam. Temazepam doesn't have direct effects on the 5-HT2A receptor.