Tasimelteon

[gh0stmAn]

Have you guys heard of this stuff? I just saw a commercial on TV advertising to people, but it took some digging to actually find what med they were advertising. It looks to be just like that Rozerm shiat..

 

[endotropic]

It's a melatonin 1 and 2 receptor agonist, so I wouldn't expect it to differ from melatonin by much other than pharmacokinetics.

 

[Solipsis]

I don't understand... there could never be a point to high affinity metalonin receptor agonism?

 

[endotropic]

I don't understand... there could never be a point to high affinity metalonin receptor agonism?

That's not what I meant to say, just that we shouldn't expect a qualitatively different experience from other Melatonin 1/2 agonists. Higher affinity is still useful compared to lower affinity because you can take less drug to get the same effect, which in general reduces the risk of off-target side effects.

I think the real advantage of Ramelteon and Tasimelteon compared to melatonin proper is their increased duration. Melatonin with a half life in the ~30min range really has a short "sweet spot" to get to bed before the effects wear off, these new drugs should avoid that problem mostly.

 

[Solipsis]

Thanks, helpful stuff

 

[gh0stmAn]

Either way its probably no different effect wise then just taking OTC melatonin.. I got scripted that Rozerm shit once and it was literally useless, normal melatonin worked way better. Its pretty pathetic how these pharma companies just barely tweak a substance and then get a patent on it when it basically does the same thing as the base substance they based it off of..