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Taramadol....addictive?

B

bongbudda

Bluelighter
Joined
May 23, 2000
Messages
1,293
Location
London
Theres been quite a lot on this board about taramadol.
My dad needs both of his hips replaced (ouch!) and he's on 150mg twice a day, I thought that taramadol was related to ibuprofen, or at least my sister the nurse says so.
But a few people have mentioned that its addictive, would my dad be at risk?
I presume not but I dont know.
 
Get your dad some heroin and save the tramadol for when he wants to quit , because giving that shit for a hip replacement is cruel.
 
Tramadol/Ultram isn't addictive. It will make ya feel better b/c of slight SSRI-like effects. But it's not addictive. i.e. no euphoria.
 
I don't know where you people get your ideas.
Tramadol is an opiod. It has the same (no, not REALLY the same, but similar) contraindications as the other drugs
in the family:
"Use in Opioid-dependent Patients: Tramadol HCl should not be used in opioid-dependent patients.
Tramadol HCl has been shown to reinitiate physical dependence in some patients that have been
previously dependent on other opioids. "
"Consequently, in patients with a tendency to opioid abuse or
opioid dependence, treatment with tramadol HCl is not recommended."
The risk of addiction is therefore low for your father, i'd say. But to say that it doesn't exist is just ignorance. Because its method of action is more
complex than simply being an opiate agonist, of course, the real situation is
more complicated. And pretty interesting, too - it metabolizes to a more
potent and longer-lasting analgesic, for one.
Personally, I've used it, and found it to be a darn good long-lasting opiate.
I'm guessing that those who claimed it was completely unaddictive simply didn't like it when they tried it. But don't take offense if that ain't the case.
 
I agree largely with U40915,
Here is another quick link to Tramadol on bluelight from not very long ago.
While in medical (or anaesthetic) jargon - it is not considered to be a true opioid (natural, semi-synthetic or synthetic), it does have activity at the opioid (mu-1) receptor - however its affinity for mu-1 is several thousand times less than morphine.
- it has 2 separate mechanisms of action
(i) opioid (mu-1)
(ii) inhibitis noradrenaline & serotonin reuptake.
That is to say - that the combination of these 2 effects is much greater than either effect added together - ie. a multiplicative effect. The inhibition of noradrenaline and serotonin occurs particularly in the decending pathways for inhibition of pain - in the brain stem and spinal cord.
When it was first re-marketed in Australia about 5 years ago, it was done on the premise that it has a lower potential for 'abuse'. However, that is not what we are seeing clinically - and also on here if you do a search on tramadol ! Many people do get a buzz out of it - and the buzz is not just the opioid related buzz - but more the enhanced [READ: synergistic opioid] Noradrenaline and Serotonin effect.
So in summary:
(i) Is an excellent step down analgesic following joint replacement that I use routinely in many of my patients after they have come of an opioid based PCA or epidural - with very high patient satisfaction scores; usually about day 3-4.
(ii) Addictive liability is not Zero, but is not as great as with true opioids. In older patients taking it for prolonged periods of time and ceasing it, it has not been shown to induce a withdrawal syndrome - and hence physical dependence has not been observed in a clinical setting.
(iii) The concern in using it in opioid dependent patients is that it may precipitate a withdrawal syndrome from true opioids - as the efficacy at the opioid receptor is so much less than morphine, it actually blocks the effect of morphine and hence acts as a partial agonist (ie. able to antagonise a full agonist to some degree).
I believe (iii) has been described in a few case reports and has a theoretical base - but I haven't observed this as yet.
As for U40915's comment regarding addictive potential in patients' who have previously been dependent on opioids - again - this has been reported, and now the drug company in order to cover themselves medico-legally prints this in the product information. As for how clinically significant this is - again ... I have not seen someone clinically have such a response ... but I am the last to say "I will never see it" ... one day ? :)
As for your sister's comments about it being an NSAID (related to ibuprofen) ... I'm afraid it has no Non-steroidal anti-inflammatory activity what-so-ever.
Hope this helps answer your question.
Ref:
The clinical use of tramadol hydrochloride: Bamigbade, Langford. Pain Reviews 1998;5:155-182
[ 06 June 2002: Message edited by: gasbo ]
[ 08 June 2002: Message edited by: gasbo ]
Click to expand...
 
Technically Ultram is NOT an opioid, well, it's a SYNTHETIC OPIOID... it's kinda lime Ambien - they wanted to create a "non-addictive pain killer" that wasn't an opioid, well, they were half right in that they developed an effective non-opioid pain killer, but it is addictive.. of course not to the same degree of some of the other opioids ..
But the IMPORTANT QUESTION - can you use it to get high? And to that the answer would be... MAYBE.. it's a lot like Soma - some people claim it's awesome while others can take a bottle full and not get any type buzz... but hey, YMMV!
[ 07 June 2002: Message edited by: PhreeX ]
 
the FIRST time i took TRAMADOL i took 50 mgs and YES a felt a nice little mellow high, if you could call it that...the times taking it after that all i got was tired and that was it...
YYYYEEESSSS, TRAMADOL, despite what anyone says is addictive...i know 2 people currently addictee to the stuff...
people need to stop putting MISinformation out there...
 
This is stupid. Of course he could become addicted to them, the risk of dependence in placebo treated patients is probably non-zero and as they make one feel slightly better tramdol would be addictive to some degree. I believe if you go searching on here I even have a medical cite for it (or maybe that was one of the other semi-opiods).
It however is probably below codeine's abuse potential.
Is it just me or does something strike other people as funny about the first post in this thread?
 
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