Honestly man it comes down to personal opinion and experience. Everyones different. For the most part, ive mostly read people like it, a lot. And heard several times its pretty euphoric and strong depending on tolerance. I actually just got 8 free 100MG cucyntas, which is tapentadol. Ive yet to take any though since its 3:30AM where im from, and dont want to waste.come on people, now
You cant get high off the bupe, it only binds 27% of your mu opiate receptors.
^^^^ NO, I am using bupe cause I am not using heroin. You cant get high off the bupe, it only binds 27% of your mu opiate receptors. And I been on H for about 8 months str8.I heard kratom sneaks through the bupe maybe. not Tapent.?
my apologies ...I would have sworn I read a post of yours in which you claimed you were taking enough bupe to feel euphoria, but then the euphoria no longer persisted after a while, but you were still getting a good nod. for some reason I equated euphoria + nodding w/ "high" but clearly that must not be right ...or maybe that wasn't you. sorry either way.
Yes, an opiate niave person could get opiate effects from bupe, but they are limited to it's capability of binding of only ~27% of your mu receptorsPardon me but this is just plain wrong. You can get very high on Bupe if you have no tolerance and no prior history with potent opis like H, Oxy or so.
In your case of course it won't get you high because of your tolerance but generally speaking it is very recreational for non tolerant individuals..
Yes, an opiate niave person could get opiate effects from bupe, but they are limited to it's capability of binding of only ~27% of your mu receptors
Sorry for off topic, but do you feel uncomfortable right after dosing too much, or does it take some time?In my experience buprenorphine at anything over 8-10mg doesn't have any added mu opioid effect and often it becomes uncomfortable when the dose is too high.
So I guess that should answer the question as to why some people get full relief and some just partial relief of pain etcFull analgesic efficacy of buprenorphine requires both exon 11- and exon 1-associated μ-opioid receptor splice variants
Sorry for off topic, but do you feel uncomfortable right after dosing too much, or does it take some time?
I experienced this a lot too, there was a weird feeling of being overly medicated, yet not feeling high. Hard to describe, other then to say certain dosages are just overkill.
I think 7-HM which is an alkaloid in kratom has a binding affinity which is still not to par with Bupe but high enough that at certain dosages it can compete. That's the only way I can explain how I can still feel kratom on top of suboxone, at least at dosages around 3-4mg (haven't tried any higher). I imagine if one found tramadol recreational with buprenorphine, one would find tapentadol even better, because isn't it basically a boosted version of tramadol in terms of mechanism of action?