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Benzos Taking Xanax with Gabapentin, useless?

ksralyv2mch

ksralyv2mch

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I've read a few places on here gabapentin reacts the same way on the GABA receptors (or w.e) as xanax does. That has lead me to ponder: is it pointless to take xanax if you are taking gabapentin? Would you not feel any effects from the xanax as if the xanax was taken alone?
 
When i was taking gabapentin for the short amount of time i was on it until it became useless (about a month).. i didn't feel the need to take my daily benzos but did anyway.
I did skip a couple doses but didn't even notice any wds.. they work on the same receptors but have different effects.
It probably depends on the individual taking the drugs on whether they feel both or just one or the other. Everyone is different.
Only way to know is try with and try without and see if you notice a difference or a waste of one or the other.

My .02
 
Yeah... I think it's a waste, but I can't tell, today I have taken 600mg Gabapentin with 10mg diazepam, 4hrs later: 300mg gaba, 4hrs later: 600mg gaba 10mg diazepam, 4hrs later: 300mg gabapentin .5mg alprazolam.

and I couldn't feel nothing from the xanax, don't know if it's cause of all the benzos I've taken, or the receptor thing, or the low dose of xanax (usually .5 xanax will make me feel a little floaty)
 
actually that's a nice combination in my book. especially when you have been taking gabapentine for a while you get like zero sedative effects without adding some benzo or opiate.
 
Yeah that's why I stopped taking gabapentin. After a month it did nothing for me anymore. I could see after it losing the nice feeling effects than benzos would be nice with it.
 
HdoubleODeezy said:
Yeah that's why I stopped taking gabapentin. After a month it did nothing for me anymore. I could see after it losing the nice feeling effects than benzos would be nice with it.
Click to expand...

Yeah but I'm only taking the gabapentin for (at max) a week, just as a comfort med for my opiate w/ds so I really shouldn't see a decline in the effectiveness of the gabapentin in a week would I?

Dosing schedule:
Day one: 600mg (4hrs later) 300mg (4hrs) 600mg (4hrs) 300mg
Day two: 600mg (4hrs later) 300 mg (4hrs) 300mg
Day three: 600mg (8hrs later) 300mg
Day four: 300mg (8hrs) 300mg
Day five: 300mg

So not even a week.
 
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You should stagger the doses for better effect and BA plus take each dose with a little snack and a soda (few crackers and a coke is what I did)..smaller amounts at a time spread out by an hour between taking more. Like instead of 600 take 300 and have a snack with it and an hour later take another 300 and another snack. That would give more effect than dropping 600 at once IMO.
But you should be all set with tolerance issues with that short of time on it.

Edit. . Never mind scratch my idea of staggering them. That's more for using it for a high.
What you're doing is good for getting clean.
 
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gabapentin was useless after a week or so on it for me..the first 2-3 days it provided nice anxiety relief, mood boost, great sleep, sex drive boost but after that it gave me terrible brain fog, lethargy, sexual problems etc etc..
 
Gabapentin doesn't even work remotely like benzos nor are the effects similar. This is like the third post this week I've had to say this lol, Gabapentin's MOA isn't fully understood but we do know it works on the a2 sub-unit of voltage-gated calcum channels and more likely than not doesn't even affect GABA at all. I've read that gabapentin can decrease the absorbtion of both benzodiazepines and some opioids but I think timing plays a huge role, at least with benzos as I've noted potentiation between the two when the benzo is taken hours after the Gabapentin.

One of the many sources:
http://m.pnas.org/content/105/9/3628.full
 
It doesn't effect GABA a or b subunits?
At all?
I can name a few types of channel blockers that also effect GABA due to the very close proximity of the receptors tricking your brain into believing it should release GABA because sometimes it can't tell the difference.
Depakote and topamax come to mind.

Edit.. I know the effects are different, that I stated. But when you take benzos and gabapentin together a lot of times you don't feel the benzo, like I stated and you reiterated. So what was said that you trying to prove wrong in this thread?
 
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Nope, not that we know of. Not surprising being that besides maybe it's anxiolytic effects it feels nothing like GABA-A or B agonists.

The mechanism of action of the antiepileptic and antinociceptive drugs of the gabapentinoid family has remained poorly understood. Gabapentin (GBP) itself was originally developed as an analog of γ-amino-butyric acid (GABA), but is now believed to have no effect on GABA receptors or transporters (for review see ref. 6). The first key whethererstanding the mechanism of action of GBP came from purification of the GBP-binding protein from porcine brain (7), which was identified as the α2δ-1 auxiliary subunit of VGCCs. It is now known that GBP binds to an exofacial epitope present in both the α2δ-1 and α2δ-2 subunits (for reviews see refs. 1 and 8 ).
Click to expand...

See article linked above for more info, or use google... whatevs.

Merge...

When did I say you don't feel the benzo when taken with gabapentin? I noticed the opposite. There have been studies saying that gabapentin however decreases the BA of benzos as well as certain opioids when taken at certain times. What are YOU trying to prove by saying that because you gabapentin decreases the effects of BZDs it works on GABA sub-units. Don't take my word for it, do your own research, I'm just throwing some info on the table... The only studies showing that gabapentin is a GABA agonist whether it be through direct or indirect means are either outdated or provide a claim with no evidence. Also the decrease in BZD effects is due to absorption, not tolerance from the gabapentin if that's what your getting at. To top it off gabapentin shares no cross tolerance to GABA agonists afaik
 
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I don't gotta prove shit, i know what i know. you know what you know. maybe im not saying what i am trying to correct..
I'm not gonna attempt it.. but im just saying that if it does not work as a gaba agonist on THOSE receptors, it doesn't mean that it still can't make your brain increase natural levels of GABA by manipulating other channels (whether it be sodium or calcium).
Not arguing..
When did I say you don't feel the benzo when taken with gabapentin, I noticed the opposite.
Click to expand...
..
Here:
I've read that gabapentin can decrease the absorbtion of both benzodiazepines
Click to expand...
with benzos as I've noted potentiation between the two when the benzo is taken hours after the Gabapentin.
Click to expand...
That's how i read it as. May not be how you meant it, but that's how i interpreted it. Seemed like you were saying the only way to get effects from both since the BA is decreased is to wait until hours after you dose the gabapentin= in my head that kinda sounds like saying they dont work well together.
 
Or... it could mean that I've never taken the two together at the same time. Just curious, how does gabapentin decreasing the absorption of BZDs (not even close to fully btw) have any correlation to whether or not there is direct or indirect effect if GABA sub-units? Btw I understand what your trying to say but given what info we've got to work with it's more likely to assume that there's no effect on GABA sub-units at all, even through other means which is why I'm telling you to do a bit of reading, not to mention the lack of cross-tolerance, unique withdrawal syndrome, and different psychoactive effects...but of course, I could be wrong, alot of gabapentins MOA isn't fully understood. Don't worry, I'm not gonna argue, in fact this will likely be my last post... I'm just curious as to what this has to do with your claim. If there's something I'm missing feel free to lemme know...

I know the effects are different, that I stated. But when you take benzos and gabapentin together a lot of times you don't feel the benzo, like I stated and you reiterated.
Click to expand...
 
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I ain't gonna argue either man, i guess i can't put what im thinking into the right words.. damn brain doesn't work all the time for me lol.
I get what you're saying, and you said you get what im trying to say so i guess we are good then.. I'm not saying you're wrong at all, but im saying being a gaba sub unit agonist isn't the only way to increase GABA production/uptake/reuptake in the brain, that's all.
 
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