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Taking MDMA while on mirtazapine regularly

Damo_40

Bluelighter
Joined
Aug 2, 2025
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Hi, I used to love MDMA when I was younger before I started taking antidepressants. I had been on SSRIs and snris and they definately killed the effect of the MDMA.

Im now only on Mirtazapine as a regular medication. I realise that Mirtazapine is a different type of antidepressant to both SSRIs and SNRIS. So I was wondering does Mirtazapine kill the high of MDMA too?

Anyone out there with first hand experience? I would love to hear anyone's story who has taken MDMA while they were on Mirtazapine regularly???
 
I've taken mirtazapine for years and after that Lexapro, which I stopped almost a month ago.

Indeed, SSRIs block the effects of MDMA, but if you stop mirtazapine and then take the drug a few weeks later, the effects shouldn't be affected.

I'm still wondering if even after stopping Lexapro, the effects of MDMA can return to the same level as before.
 
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