Taking antipsychotic, would I have a problem with pyschs and ketamine?

[weevil]

Not at the same time Mostly interested in ketamine, I'm due to get some and want to enjoy it. I know I'd have to watch my breathing but will it dull any effects?

Not planning on taking any psychedelics for a while, had a last hurrah a week or so ago with amt and it made my brain sore (wasn't on the meds at the time) if I do go back any time soon it'll be 2cb or acid that tempt me.

Thanks in advance,

 

[sekio]

Ketamine does not depress breathing appreciably.

Antipsychotics do not mix with psychedelics, but ketamine is a dissociative drug. I wouldn't expect too much difference in terms of effects.

 

[weevil]

Thanks, that's reassured and made me happy. I'd read a drug interactions chart or page that said the 2 together could seriously slow your breathing.

I with leave the trips alone, I want to for a while anyway even if I wasn't on the meds.

 

[abrad84]

I would tend to think that ketamine and it's ilk would be ill advised for anyone who needs to take antipsychotics.

 

[Roger&Me]

Antipsychotics do not mix with psychedelics, but ketamine is a dissociative drug. I wouldn't expect too much difference in terms of effects.

5HT2A antagonists reverse the disruptive effects of NMDA antagonists on sensorimotor gating and on object recognition in animals*, so antipsychotics may reduce the effects of ketamine. That being said, I've never tried the combination myself, and there have been no studies performed in humans that investigate the role of serotonin in the action of NMDA antagonists.


[*]Varty, Bakshi & Geyer Neuropsychopharmacology 20, 311-321 (1999)

 

[PsychedelicDoctor]

Certainly in medicine, ketamine use is contraindicated among those with a history of mental illness. That being said, it's also largely because there are better induction agents for anesthesia. I don't believe it's due to any interactions between the two drugs but rather the effects of K on a fragile psyche. Which antipsychotic are you taking? Hope that helps some

 

[weevil]

Pericyazine, it's an old one. Apparently local shrinks recommend it to the GPs, my GP said today it was because of it's lack of addiction.

I'm not too worried about my mental state and taking K, it wouldn't be all the time.

 

[blazR]

I had an old buddy(doesn't talk with him anymore) who was medicated with Seroquel and Rivotril(amongst others) for at least 15 years.

It did not seem like the antipsychotics was killing his ketamine trips at all. But can't say for sure.


//blazR

 

[CheapHighMan]

Nah I'm on abilify 2mg and my dxm trips still make me leave the universe ure good. I can't say the same for shrooms though antipsych might ruin you're psychedelic trips.

 

[abrad84]

I'm not too worried about my mental state and taking K, it wouldn't be all the time.

Well maybe you should be!

Taking Ketamine, or indeed any dissocitives would be a terrible idea for somebody suffering from mental illness, regardless of how infrequently it is used.

 

[TheUncreated]

5HT2A antagonists reverse the disruptive effects of NMDA antagonists on sensorimotor gating and on object recognition in animals*, so antipsychotics may reduce the effects of ketamine. That being said, I've never tried the combination myself, and there have been no studies performed in humans that investigate the role of serotonin in the action of NMDA antagonists.


[*]Varty, Bakshi & Geyer Neuropsychopharmacology 20, 311-321 (1999)

OP, Roger&Me hit it spot on here. The only thing i would add is that there have been studies conducted on the concomitant use of benzodiazepines (midazolam if i remember correctly) with ketamine, and from a medical perspective this combination decreases the "psychiatric side effects" of ketamine. Which unless I'm mistaken are what we're after here... but I don't think I've ever encountered any literature on any inhibiting effects of antipsychotics/neuroleptics. So, I second everything that's been said.

Also, Abrad, ketamine is being vigorously investigated these days (with formidable success) for its use in treatment of depression, bi-polar, and many other psychiatric disorders, many researchers have been shocked by the level of instantaneous and effective relief ketamine seems to provide in treatment resistant depressives. Of course, I'm not advocating reckless unsupervised self medication, but it is pretty damn interesting to read about all these new avenues of research for Ket popping up left and right,

 

[abrad84]

Of course, I'm not advocating reckless unsupervised self medication, but it is pretty damn interesting to read about all these new avenues of research for Ket popping up left and right

I am aware of it being investigated for various medical applications but there is a big difference between being treated with it while under the supervision of a doctor and using it recreationally.

I stand by my belief that psychedelics and dissociatives should not be taken by anybody who is being treated for mental illness unless under the supervision of a doctor.

 

[weevil]

I don't have psychotic episodes apart from 2 exceptions I believe were caused by SSRI's. It's for my anxiety mostly and possibly my obsessional behaviour I was mistaking for bi polar. the local shrinks recommend this older anti psychotic, pericyazine, it to the GPs and it's helped already more than SSRIs or tricyclics did despite some of the side effects.

I may tell my doc about the k (which I haven't done yet though a mate said when he gets some he'll give me a couple lines when I go round) or someone else I regularly speak to. She trusted me with valium while I researched the anti psychotic first even though she knows of my self destructive drugs binges and much more often self medication attempts. I'm not looking to k hole, just fancy a few bumps now and again, just as if I were sitting there drinking a beer. Funnily enough the doc's more worried about me drinking during freshers week, I laughed cos I'm too old for that, not a big drinker which is lucky since my housemate pretty much turned the kitchen into a brewery. Not so keen on the dark ales he makes from the start anyway.

 

[abrad84]

I, as you say, you are prone to "self destructive drug binges" then that is yet another reason to avoid keta,ine. It seems to be something that can fuck people up much moreso than other psychedelics. Please think carefully if ketamine is something you need in your life at the moment.