Opioids Tagamet and apap

[thurston]

Does taking Tagamet with an apap containing opiate increase the chance of liver damage?

 

[Oxide]

It actually may have the opposite effect.

Put simply, that study says that cimetidine may actually "decrease the chance" of liver damage caused by an APAP overdose.

Pharmacokinetics of acetaminophen elimination were studied in normal volunteers with and without co-administration of cimetidine 300 mg every 6 h. In normal volunteers, cimetidine decreased the fractional clearance of the oxidized (potentially toxic) metabolites of acetaminophen more than the conjugated metabolites. This finding confirmed the hypothesis that cimetidine is a relatively selective inhibitor of the oxidation of acetaminophen to reactive metabolites in man as well as in animals. When considered together with the results of previous studies showing improved survival and decreased hepatoxicity in acetaminophen-poisoned animals, the present results provide a rational basis for assessing possible benefits of cimetidine treatment of acetaminophen overdoses in man

 

[sekio]

Don't rely on it being a lifesaver for you though.

 

[mydrugbuddy]

I've just started using Cimetedine recently, and am finding it very effective for potentiating Etizolams and Poppy pod tea. Within my tub of cimetidine was a smaller sealed tub, couldnt read the text on the tub which was presumably describing the contents.

I've sliced open the tub now to reveal some small black and silver crystal type substances inside. WTF ?

Any one have any idea what these things are, and what their use/abuse potential is please ?????

Any helpful replies would be much appreciated as always. Please dont bother with UTFSE replies. I already have tried.

 

[brutus]

^ Could be some sort of desiccant to absorb moisture but doesn't sound like it. Basically, no one will be able to tell you for sure and that's why substance ID questions aren't allowed on Bluelight.