I can't speak on behalf of all psychedelics, but during my experience with 2C-E I had clonazepam in my system the whole time; .25 before sniffing the 2C, and then .5mg once I came down and slept (though that day was weird and I was very tired very early, but sleeping any appreciable amount of time is impossible for me after tripping).
I have both plenty of experience, and a low, but "definitely there" tolerance to benzos. You should be fine, but use low doses as always until you know how they'll react within you.
Happy trails!