Pegasus
Ex-Bluelighter
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- Aug 15, 2006
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This study really interested me, and I think many on here will find this interesting as well. If anyone can get the full text of this, it would be greatly appreciated!
Effects of enriched environment on morphine-induced reward in mice
References and further reading may be available for this article. To view references and further reading you must purchase this article.
Zhiwei Xua, Bing Houa, Yan Gaoa, Fuchu HeCorresponding Author Contact Information, a, E-mail The Corresponding Author and Chenggang ZhangCorresponding Author Contact Information, a, E-mail The Corresponding Author
aBeijing Institute of Radiation Medicine, Beijing 100850, China
Received 3 October 2006;
revised 16 December 2006;
accepted 28 December 2006.
Available online 27 January 2007.
Abstract
Drug addiction and abuse have been extremely serious problems in our society. The effect of different environmental conditions on the susceptibility of human to drug addiction and abuse is still not fully understood. It was recently reported that enriched environment can trigger long-term modification in neural functions and might prevent the occurrence of pathogenic behaviors. Here we investigated the effects of enriched environment on morphine-induced reward in mice. We found that the enriched environment attenuated the acute morphine (10 mg/kg)-induced hyperlocomotion and repeated morphine (10 mg/kg)-induced behavioral sensitization. Moreover, the environmental condition blocked the conditioned place preference (CPP) of the mice induced by morphine (5 mg/kg). Associated with behavioral alterations, the expression of FosB-like proteins in the nucleus accumbens of the brain was down-regulated in the mice housed in the enriched environmental condition, but not in the standard environment. Taken together, these results indicate that enriched environmental condition leads to decrease in sensitivity of the mice to morphine-induced reward.
http://www.sciencedirect.com/scienc...bb6c983e110c298aea06d16b8ef50eb7&searchtype=a
Effects of enriched environment on morphine-induced reward in mice
References and further reading may be available for this article. To view references and further reading you must purchase this article.
Zhiwei Xua, Bing Houa, Yan Gaoa, Fuchu HeCorresponding Author Contact Information, a, E-mail The Corresponding Author and Chenggang ZhangCorresponding Author Contact Information, a, E-mail The Corresponding Author
aBeijing Institute of Radiation Medicine, Beijing 100850, China
Received 3 October 2006;
revised 16 December 2006;
accepted 28 December 2006.
Available online 27 January 2007.
Abstract
Drug addiction and abuse have been extremely serious problems in our society. The effect of different environmental conditions on the susceptibility of human to drug addiction and abuse is still not fully understood. It was recently reported that enriched environment can trigger long-term modification in neural functions and might prevent the occurrence of pathogenic behaviors. Here we investigated the effects of enriched environment on morphine-induced reward in mice. We found that the enriched environment attenuated the acute morphine (10 mg/kg)-induced hyperlocomotion and repeated morphine (10 mg/kg)-induced behavioral sensitization. Moreover, the environmental condition blocked the conditioned place preference (CPP) of the mice induced by morphine (5 mg/kg). Associated with behavioral alterations, the expression of FosB-like proteins in the nucleus accumbens of the brain was down-regulated in the mice housed in the enriched environmental condition, but not in the standard environment. Taken together, these results indicate that enriched environmental condition leads to decrease in sensitivity of the mice to morphine-induced reward.
http://www.sciencedirect.com/scienc...bb6c983e110c298aea06d16b8ef50eb7&searchtype=a
