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Bupe Sure way to be free of prec. withdrawals?

Crashing said:
Buprenorphine, a partial antagonist, has a stronger affinity for the Mu opioid receptor (the receptor responsible for feelings of euphoria and well being) than full agonist opiates. At the same time, it has a lower intrinsic effect, so while it occupies the same space in the receptor and trumps the other opioids, it activates them to a much lesser degree.

When we directly replace full agonist opioids with buprenorphine, the result is an unpleasant shock as the entire receptor site is more or less spontaneously replaced by something with less 'net activation'. The user feels an immediate loss of comfort due to the entire receptor site being attenuated all at once.

Gradual Titration allows the buprenorphine to slowly trade places with the full agonist opioids without the user knowing because there is no average "net loss" of receptor activation which is the feeling of being high.

Eventually at the end of the titration, the buphrenorphine now covers the entire receptor area, but the user never became physically aware of this transformation in any sort of unpleasant way, because it took place in a gradual fashion.

Sorry about the bad metaphors in the previous post.
Click to expand...

You are definitely wrong about gradual titration of bupe ending the possibility of Precip. W/D. It may play a tiny role in lessening the severity but there have been many reports of heroin overdoses that are reversed by placing a small amount of bupe under the persons tongue which kicks off the full agonist Heroin and this in turn awakens their CNS so that they can breath on their own. This is basically the same as putting the OD victim into precip. W/D.
 
^ Just to add the main factor in determining if u do or don't get PW/D is your tolerance level at the time of bupe induction. If it's not much more than equiv. to 30mg/day methadone them the bupe should replace that just fine. Main reason PW/D is associated with methadone is because of the long half life and it being fat soluble so even if you are no longer feeling your methadone dose the fact is someone on MMT has a lot built up in the system which would take much longer to eliminate completely because each day u dose there is still a good amt. of Methadone still on board which starts to cause build up even though u feel like it's time for another dose you're not yet in bad W/D but really your levels are just lower than you're accustomed to so it's uncomfortable.
 
I was on 80mg methadone for about two years before switching to Suboxone. Doc gave me three days worth of oxy to take before taking subs. I snorted it all the second day, lol. I waited until it was 72 hours after my last methadone dose before taking the sub. I thought I'd be fine. I sucked on the sub as my family drove to a restaurant. I was fine until we sat down when precipitated withdrawal hit me. Holy God. I managed to eat but it was terrible.
 
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