Super weak roll this morning... Can redose much higher tonight?

[dankplantgrower]

Hi all I ate a couple green biohazards and half a purple buddha this morning. I "felt something" I guess but overall it was vveerryy mild and overall quite unenjoyable. Anyway if I doubled my dosage (or even a bit over), as well as changed ROA, could I still get a roll in tonight, before the week truly sets in? My connect is telling me a customer insufflated the purple buddha and was getting "head rushes", so I was thinking about snorting some of the next dose too.

Thoughts or suggestions?

 

[Folley]

No.


I've taken too low of a dose and tried to redose only a few hours later with 2 times what I did the first dose... it did nothing but keep the super weak roll i had going for an hour longer. Also, snorting an untested pill that your dealer says got someone high is fucking stupid..... I'm sorry, but that's the truth of it.

MDMA tolerance takes effect almost immediately, there is no "getting in a roll" before it takes effect.

 

[Sleaze]

MDMA deserves a lot of respect - dosing in the morning, regardless if it's low medium or high, then again the same night is just a bad idea, full stop.

MDMA is a wonderful thing, and if you want to be able to enjoy it for months to come, then show it the respect it deserves. Don't try re-dosing tonight, or tomorrow, or the weekend. Allow yourself a good few weeks in between rolls. As difficult as that may sound, it's for the best in the long run, both for your brain and enjoyment level.

 

[JWills20]

No.


I've taken too low of a dose and tried to redose only a few hours later with 2 times what I did the first dose... it did nothing but keep the super weak roll i had going for an hour longer. Also, snorting an untested pill that your dealer says got someone high is fucking stupid..... I'm sorry, but that's the truth of it.

MDMA tolerance takes effect almost immediately, there is no "getting in a roll" before it takes effect.

Disagree. My first ever roll I took too little, then redosed 2 hours later and had an awesome experience. If the drug is barely psychoactive, it's not changing the neurochemical balance of the brain at all, so I don't see how a tolerance to the drug can be ascertained.

@OP, you should question the legitimacy of your pills. Remember that just because your dealer or friends said they are MDMA, doesn't mean they are. If you're consuming unknown chemicals then of course doubling your dose isn't going to help. Buy a test kit and use PillReports to find out the exact potency of what you're taking. From there, you can get the dose right from the start and you'll avoid taking potentially dangerous chemicals. Win Win situation.

 

[Folley]

^ he says the roll was weak, not that it wasn't a pharmacologically active dose.


From my experience I took 60mg (a lab tested pill) and redosed with 120+mgs even just an hour or two later... still, I barely got any enjoyable effects from the drug. By now it is MUCH too late.

it's not changing the neurochemical balance of the brain at all, so I don't see how a tolerance to the drug can be ascertained.

did you find a study for this? Last I checked this was a theory of yours but you didn't seem to find anything proving it one way or the other. Obviously larger doses will create larger changes in the brain, but I don't think there is just a point where it goes from "no change" to a drastic drop in serotonin levels

 

[severely etarded]

Can you? Sure we can't stopyou lol. Should you? No...

 

[JWills20]

^ he says the roll was weak, not that it wasn't a pharmacologically active dose.


From my experience I took 60mg (a lab tested pill) and redosed with 120+mgs even just an hour or two later... still, I barely got any enjoyable effects from the drug. By now it is MUCH too late.



did you find a study for this? Last I checked this was a theory of yours but you didn't seem to find anything proving it one way or the other. Obviously larger doses will create larger changes in the brain, but I don't think there is just a point where it goes from "no change" to a drastic drop in serotonin levels

Ok then, I've also had a weak roll which then turned into a full blown. Basically I took my redose (which was 50mg) by accident instead of the main 100mg bomb. When it kicked in it was mild so I figured I'd dropped the wrong one. Once I took the 100mg and that kicked in it was overly intense though. It's all anecdotal really.

MDMA is rather well known for having a steep dose-response ratio, usually beginning the large ascend at the 100mg mark. I remember reading a study which saw plasma serotonin steeply rising at the 100mg mark, I'll try and find it if you're really interested. So, in effect, there is a point where serotonin does begin to drastically increase - it's not linear. Further, neurons release neurotransmitters only when becoming significantly depolarized via Action Potentials. The polarization of the cell has to reach a certain voltage before it will release the neurotransmitter. If the dosage of MDMA, or any drug for that matter, was not significant to cause an AP then nothing will be released. However, I don't know if the neuropsychopharmacology of drugs that cause neurotransmitter release follows the same principles. I'm just applying the foundations of neuronal signalling (from my Cognitive Neuroscience book) to MDMA.

My original quote was sloppy - it does alter the neurochemical balance - albeit only slightly. However, I don't see why you couldn't take more and still experience the same effects? How is that original dose going to stop the follow-up dose from binding to 5-HT neurons and releasing serotonin? Could you, or anyone else, provide some science as to why that would happen?

 

[Folley]

It's not going to stop it (nothing will, not even SSRIs), although I don't think it would be nearly as effective.

I'd be interested to see a study on how quickly MDMA tolerance takes effect and at what kind of doses, but that kind of self-administered harm in humans is very taboo among the research community so we're unlikely to be graced with anything so useful.


From an HR standpoint, however, we have no idea what he dosed at or why it's not working... it could be PMMA with it's long come up time and extremely sharp dose-response curve or he could have been taking MDMA every week and tolerance may be the reason why he isn't getting high enough. There's a number of possibilities here, most of them not good. I cannot recommend in good faith that he "redose much higher", especially so soon. Although by now he's obviously made his choice so it's a little moot