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Opioids Suddenly immune to opiates/opioids

T

TheDoo

Greenlighter
Joined
Jun 19, 2014
Messages
3
Hello, I was prescribed 60 Norco 5/325 and I mostly used them as prescribed until my last 20 or 30 or so I used them to get high about 3 or 4 times. It took 15 mg to leave me feeling absolutely wonderful. With my last 10 Norco I suddenly stopped feeling anything on 15 mg, so I did some research and with my last 4 pills (20/1300 mg my poor liver) I took 110 mg of DXM (I've done DXM before) but I still felt absolutely nothing.

I had no more pills left so three weeks went by until I got some Roxicodone from a friend. They were 5 mg instant release. I started with a 15 mg dose, felt absolutely nothing so took another 5 mg about an hour later. Disappointed, the next night I took 30 mg and felt no effects. Nothing. Tried a 40 mg dose, zero effects except nausea and light headedness. I wouldn't have even felt any relief from pain. The highest dose I took was 50 mg of Roxicodone, which left me with nothing but nausea and I did end up vomiting. I vomited quite a bit too so I wouldn't want to take any more than that.

Long story short, I went from being high off 15 mg of hydrocodone to feeling nothing but sick from 50 mg of oxycodone in a very short amount of time! Am I suddenly immune? I've been high less than five times. Is my only option just quitting opiates?
 
I'd say it probably would depend on a few things (empty stomach vs. full stomach for starters since those opioids present maximal effects on an empty stomach) but then again everyone is different.

Also, DXM I do find does potentiate a little bit but it is more to prevent tolerance via NMDA receptor antagonism. 100mg is probably too much as you'd want to stick to between 45-60mg.

Also for example, if you took 20mg of hydrocodone for recreational purposes two or three consecutive days, it is very conceivable that that dose would stop providing the euphoric effects etc. you were seeking. Even 20mg today on an empty stomach vs. 20mg tomorrow on a full stomach will make a huge difference.

There are also cases of acute tolerance as documented from a study where they gave morphine to rats.

Acute morphine treatment significantly increased not only the firing rate and firing population but also the power of slow oscillation of DA neurons in naïve rats. These changes lasted at least for 3 days following the morphine treatment. During this period of time, responses of the DA neurons to subsequent morphine challenge were diminished. We further demonstrated a transient desensitization of opiate receptors as monitored by GTPγS binding to G-proteins. The present study provided first direct evidence for the temporal changes in the VTA DA neuron activities and opiate receptors desensitization.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603002/
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Quitting opiates (which hydrocodone and oxycodone are technically opioids, not opiates) is actually a great plan because I can tell from your rather short post that you loved the feeling opioids provided and are seeking or chasing that again.

This is not at all to judge mind you, far from it because you are far from alone. Quit while you're ahead because if you keep this up you're going to keep it up and end up in a situation where stopping opioids is going to put you in wd and a world of hurt.

Opioids make you sick right now when you take them. This is a reason to stop before you get to the point where you get sick from not taking them. And it is not 'just like getting the flu' but rather a hell of a lot worse; both in physically and mentally.
 
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But it worked so great a few times
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You're not the first person to experience that. This is how a lot of people get suckered into opioid dependency. It turns out that the different effects of opioids (breathing depression, painkilling effects, feel-good effects) all build tolerance at different rates. The euphoric feel good effects disappear pretty quickly.

If you're pushing the dose to the point where you get nausea and vertigo, you're obviously getting the drug to your brain, but it's just not activating the pleasure circuits. And there's not a lot you can do other than go do something you enjoy, other than opioids... don't expect to be in heaven forever.
 
TheDoo said:
But it worked so great a few times
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Quite alot of people feel nothing but "out of it" or groggy from opiates when they take them. It is somewhat unique that you did feel euphoria to begin with, but it's definitely not outside the realm of imagination to think that that euphoria could stop.
 
When I first tried opiates back in 2,000, I would get dizzy & nauseated & just didn't like them so stopped. It took 10 years before I tried them again & for some reason they worked great.

You should think of what is happenening to you as a blessing in disguise & just leave it at that........it is kind of strange how you got high off 15mgs of hydrocodone but after several uses, no more.

The only bad part I see is if you actually needed pain meds for actual pain.
 
All I can think of whenever I see the title of this thread is "Damn, that sucks."
 
I would resist the temptation to continue
Taking larger doses as vomiting is one of the first symptoms of over dose.. take more and it can combine with being passed out and the you can get aspirate your vomit and wind up dead or on a ventilator.

Opiates may just not be a good substance for you. Its also seems you have the potential to get an actual addiction. As chasing a high we will never have again despite negative experiences is addiction in a nut shell.
 
sekio said:
You're not the first person to experience that. This is how a lot of people get suckered into opioid dependency. It turns out that the different effects of opioids (breathing depression, painkilling effects, feel-good effects) all build tolerance at different rates. The euphoric feel good effects disappear pretty quickly.

If you're pushing the dose to the point where you get nausea and vertigo, you're obviously getting the drug to your brain, but it's just not activating the pleasure circuits. And there's not a lot you can do other than go do something you enjoy, other than opioids... don't expect to be in heaven forever.
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Ahh. Makes sense. I'm just gonna stop taking them. It sucks, I wouldn't mind indulging in those effects at least once a week or so. It just felt so nice.
 
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