Substituted amphetamines activate carbonic anhydrases

[Seppi]

I originally learned about this today from IUPHAR/BPS, which cited this paper: https://sci-hub.tw/10.1016/j.bioorg.2019.03.062 (covers amphetamine and histamine)
Then found this paper from a pubmed search: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009978/ (covers amphetamine, methamphetamine, and other substituted amphetamines)

My original post about this is here: https://www.bluelight.org/xf/threads/baisic-guide-to-amphetamines-in-neurology.882189/#post-14704845; I figured it was worth pointing out in a separate thread.

 

[Allylbenzene]

I've shared updated info on this here:

Stimulants Thread 'Underrated harm reduction method for all amphetamine users (adderall, vyvanse, meth, speed)'

Oct 5, 2025

This post is for anyone who regularly takes amphetamines (adderall, vyvanse, meth, speed) and wants to make things a bit more sustainable.

It turns out that amphetamines increase an enzyme called Carbonic anhydrase.

We report here that amines structurally related to amphetamine...such as amphetamine, methamphetamine, phentermine, mephentermine, and chlorphenteramine, potently activate several carbonic anhydrase isoforms involved in important physiological functions.
— https://doi.org/10.1080/14756366.2017.1375485

So what does Carbonic anhydrase do?

Carbonic...

• Allylbenzene
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• Forum: Other Drugs

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