• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Suboxone to relieve Fentanyl Symptoms?

U

Unlucky

Bluelighter
Joined
Apr 26, 2007
Messages
594
Hey all , its me again...the mystery wrapped in an enigma !!

Ive decided if the medical world isnt ready for me yet after all the failed attempts from Dr's and and Specialists I finally decided I would go and self medicate myself. To be honest I need a real life Dr House.

Ive put myself on a opiod desinsitization program in the hope that my body will finally be able to take opiods for my pain without having adverse reactions. So far past 2 weeks Ive sucesfully been able to take 1/4 of a tramadol and keep a fentanyl patch on 3 hrs a day with only minor adverse reactions, at this rate hopefully by next year I can actually start taking doses enough to relive the pain without having adverse reactions.

The main problem so far is respiratory depression and itching and bumps all over my neck and scalp mainly from the fentanyl. After a bit of research I found out that the antihistemines I bought were useless against fentanyl induced itching (opioid induced pruritus) as fentanyl itself does not cause any histamnine release. So I read that an ultra low dose of naloxene taken along with the fentanyl could releive some of the symptoms including the itching.

So I went to my Dr and requested some Naloxone, but she said it was unavaliable in Australia in an oral form and prescribed me something called Suboxone instead. It seems Suboxone has an additive called buprenorphine which im reluctant to try due to my severe chemical sensitivity. The only information I could find for Suboxone is for its use against opiod dependancy, I on the other hand have the opposite problem, I cant take any opiods without having an advese reaction. Can Suboxone help in my uncommon case too? or is the buprenorphine additive in there likely to cause further issues if I use it to releive my adverse reactions to fentanyl?
 
suboxone may help, but buprenorphine is also a pretty powerful opioid, even if it's a partial agonist.
 
In that case what if I used Suboxone by itself for the purpose of a painrelief medication without taking the fentanyl or tramadol, or will the naloxone in there cancel out the pain releiving properties of the buprenorphine?
 
like it's been said a billion times: the naloxone does nothing.

SL or orally or snorted (unsure about this one) it's all destroyed. Unless you inject it, it mostly does nothing. Even then, buprenorphine has such a high affinity for the receptor that it beats naloxone every time.
 
Thanks Hamilton, Il try using Suboxone for treating my pain then. Im in a lot of pain but I also have adverse reactions to narcotic agents so I need a painkiller but I also need a medication to counteract the adverse reactions. Suboxone sounds like it has the potential to do both.

When you say naloxone does nothing orally I hope you dont mean its ability to reverse respiratory depression and other adverse reactions.


Edit: According to these articles though a low dose of naloxone taken orally with opioids reduced the opioid induced pruritus...........

http://www.rch.org.au/pharmacy/drugs/index.cfm?doc_id=2113

http://www.ncbi.nlm.nih.gov/pubmed/11412287
 
Last edited:
Neither of those articles say that. They're both about IV naloxone. The latter one does mention oral naltrexone, which is not naloxone.
 
The naloxone is in there to keep junkies from shooting it. It will cross the BBB if administered IV (or IM/SC I think?) and react badly with the opiate.
 
Ok so the naloxone in there will do nothing for my adverse reactions? This is all I need to know!

Im not here to debate or prove anyone wrong! Im just in desperate need of help to manage my pain and have failed in doing so after specialist and Dr's were unable to help me. I just need a straight forward answer instead of bouncing back anbd forth.

Its very basic..Im in Pain, and Im allergic to narcotioc agents and I need to be able to take at least one without having an adverse reaction and if thats not possible I need to find something that will releive the adverse reaction so I can take painkillers, THATS BASICALLY IT!!
 
Have you tried a very high quality strain of cannabis indica? That can be extremely helpful for people in pain who react badly to opiates.
 
Gaian Planes said:
The naloxone is in there to keep junkies from shooting it. It will cross the BBB if administered IV (or IM/SC I think?) and react badly with the opiate.
Click to expand...

right, effective with pentazocine, not buprenorphine.

it crosses the BBB fine by any ROA, but it also gets destroyed quite well by all the others.
 
Ham-milton... can you please try and be more clearer with me, I dont understand the abreviations and the scientific terms being used, you know could you like give it to me as basic as possible for eg... "naloxone will do nothing orally for your adverse reactions so you can use suboxone or pentazocine with a naloxone combination to treat you pain effectively as the naloxone is overpowered but it will not help for the adverse reactions"....you know something along those lines woul be very helpful, thank you
 
Last edited:
Gaian...I used to be a regular pot smoker until I developed the neurological condition (Autonomic Dysfunction) and then I found that even small amounts of cannabis like 1 or 2 puffs would end up making me overheate and cause my heart to become iregular and i'd end up feeling extremely ill like I was in need of emergency help.

So to me it seems that my body rejects everything that stimulates it or anything that has the potential to get me high. I havent been able to get high of anything in the past 8 years, I dont think its even possible anymore cause any attempts ends up making me feel very ill right away before I even get a chance to experience a high and if i end up pushing it any further I speculate it could have a drastic outcome.
 
"naloxone will do nothing orally for your adverse reactions so you can use suboxone or pentazocine with a naloxone combination to treat you pain effectively as the naloxone is overpowered but it will not help for the adverse reactions"
Click to expand...

you've already figgered it out.

bbb = blood brain barrier

roa = route of administration.

moa= mode of action
 
Ham-milton said:
you've already figgered it out.
Click to expand...

lol, dont give me too much credit, it was just a lucky guess, oh and you did drop me a few subtle hints I guess 8)

Thanks for the explanation of those abbreviations

Edit: and now that I have an answer , this thread can rest in peace :) I'll start on the suboxone today and il post back if theres any issues. Thanks all
 
what about capsascin creme applications? There is a new formula that you spread on part of your body which results in an extreme burning sensation (you also use a numbing agent so you can't feel the burn I believe). This results in the release of endogenous opioids. I'm hazy on the details...perhaps somebody else knows more.
 
Interesting idea that I need to cause more pain to experience pain relief, I might consider it though. First im thinking of giving suboxone a try as a pain relief medication. Goin into Dr's today for bit more advice on that.
Thanks Gaian for your help :)
 
no problem man...yeah its a weird idea...you actually don't feel any pain (because of the numbing agent)...its a strange idea whoever had it.

anyways, best of luck to you, friend <3
 
Chances are you are going to have the same reaction to bup. Fent would be the doc in your situation, but it does not seem that way...

We will wait and see.
 
You must log in or register to reply here.
Top