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Opioids Suboxone - Spaced out - Feel crappy

M

monkeyshine

Greenlighter
Joined
Mar 26, 2010
Messages
15
So, without too much back history, I've been taking a shitload of loperamide a day and decided to quit... started subs 5 days ago...been taking 24 mgs a day roughtly and now I'm spacing them out further and further and taking less each time.
Yesterday I felt great. fucking perfect.
Today started great and I had no feelings of being in WDs so I didn't take my dose until much later..like noon. I was wired all day...and not like "yay! an opiate is in me and i'm gonna clean the house now!" but more like I took too much caffeine and cocaine and now my eyes are 3 inches wide and bulging from my head.
As if I was on the verge of being manic but at the same time having this anemic "im leaking blood somewhere and its making me weak" feeling if that makes any sense at all.

I feel like I need to come down but if it's too much bupe, it's taking it's sweet time. I very well could just be over saturated with it? I don't know what it means when they say that it becomes an antagonist at higher doses....what's that mean insofar as how it would make you feel?
I'll point out that not once have I ever felt like I was on an opiate...no nausea...no euphoria...just..normal-ish.

Thanks

m
 
... You were taking a lot of loperamide... and went on 24mgs sub per day?

That seems like WAY too much suboxone to come off of anti diarrhea medicine..
 
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Yes, you are most certainly "over saturated" with it. Buprenorphine is extremely powerful, and it has a full agonist metabolite named norbuprenorphine, which is responsible for most of the analgesia, euphoria, nods, etc.

The more you abuse full agonist opiates, the more and more opioid receptors you build that you now have to fill (along with endorphin/enkephalin downregulation), so high dose buprenorphine (8mg+) will saturate your receptors, since it's meant to be a competitive partial agonist with a higher affinity for the MuOR and DOR than norbupe or other full agonists, blocking out beneficial full opioid agonists like your own endorphins (!) or norbuprenorphine.

If you had a moderate habit (ie. addicted to snorted or plugged oxy), then taking too much buprenorphine will "overfill" your MuOR and DOReceptors, and not let any of the valuable norbupe though. ;) So, if you're using it to taper, with a moderate habit, take 4mg after 24 hours, then 2mg/day for 5 days, then 1.5mg for 4 days, then 1mg for a week, then 0.75mg for a week, then 0.5mg for a week, then 0.25mg for a week, then 0.25mg every other day for a few days, then 0.25mg every 3 or 4 days for a week and jump off with a perfect taper! :D

Good luck, man, and keep us updated! :)
 
^^^ And I'd even say that's too long of a taper. You can certainly do it in less time.

One of the problems I've always encountered is not having enough Bupe to do a taper lasting that long, however I've done many successful tapers inside 7 days.
 
Crashing said:
... You were taking a lot of loperamide... and went on 24mgs sub per day?

That seems like WAY too much suboxone to come off of anti diarrhea medicine..
Click to expand...

160mg a day of lope is every bit of a huge methadone habit. It's not something you try kicking cold turkey twice.
 
Thanks for the advice! I got up to 24 because the first 2 days were touch and go...WDs breaking through bigtime. I agree that oversaturated is an accurate description of how I feel.
I honestly hope I need that little bupe from here on out. I'm running out of cash.
 
ErgicMergic said:
Yes, you are most certainly "over saturated" with it. Buprenorphine is extremely powerful, and it has a full agonist metabolite named norbuprenorphine, which is responsible for most of the analgesia, euphoria, nods, etc.

The more you abuse full agonist opiates, the more and more opioid receptors you build that you now have to fill (along with endorphin/enkephalin downregulation), so high dose buprenorphine (8mg+) will saturate your receptors, since it's meant to be a competitive partial agonist with a higher affinity for the MuOR and DOR than norbupe or other full agonists, blocking out beneficial full opioid agonists like your own endorphins (!) or norbuprenorphine.

If you had a moderate habit (ie. addicted to snorted or plugged oxy), then taking too much buprenorphine will "overfill" your MuOR and DOReceptors, and not let any of the valuable norbupe though. ;) So, if you're using it to taper, with a moderate habit, take 4mg after 24 hours, then 2mg/day for 5 days, then 1.5mg for 4 days, then 1mg for a week, then 0.75mg for a week, then 0.5mg for a week, then 0.25mg for a week, then 0.25mg every other day for a few days, then 0.25mg every 3 or 4 days for a week and jump off with a perfect taper! :D

Good luck, man, and keep us updated! :)
Click to expand...

Is this also why people say they get high off bupe at low doses vs high?
 
Taking a high dosage of buprenorphine like that tends to over-saturate most of your mu-opioid receptors to the point where buprenorphine will start spilling into other receptors. This is probably why it doesn't feel that good to you.

I don't think I could even tolerate that much of it.
 
Crashing said:
yeah man you probably only need like 2-4mgs.
Click to expand...

Ok I'm gonna try 4mg in the am and see how it goes.

Right now I feel like shit. My hands and feet are cold, my face is tingly, I'm uncomfortable in my own skin. Feels wrong.
Not tired in the least.
 
monkeyshine said:
Ok I'm gonna try 4mg in the am and see how it goes.

Right now I feel like shit. My hands and feet are cold, my face is tingly, I'm uncomfortable in my own skin. Feels wrong.
Not tired in the least.
Click to expand...

I am sorry to hear you feel this way, but think of this as a good thing.

If Suboxone was not so unpleasant at high dosages, some people would get a kick out of abusing Suboxone as if it were heroin.

Since Suboxone only feels good at modest dosages or when you're maintained on it, it allows the drug to be an amazing tool for people who have a tendency to abuse full agonist opiates. There's very little to nothing to be gained out of abusing Suboxone, and that's what makes it a very good maintenance drug.
 
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