Bupe isnt like most drugs for the fact if you double the dose you wont double positive effects, youll actually diminish them. Kind of like after you smoke like a G of hydro nugs if you smoke 2 Gs you wont get much higher at all.
Suboxone in say 2-4mgs will produce a noticeable(some people more so then others) energetic euphoria. In doses like say 8mgs because the drug works on blocking certain receptors(mainly dopemead) and due to the excess amount of receptor blockers running around your brain with nothing to do in the higher doses they begins to block the other certain rectors that are causing the euphoric energetic buzz in lower doses! Sorry if this doesnt help, this was the best i could explain it while keeping it simple..
-472 for being one of the dumbest posts ever...
please don't post if you have NO CLUE what you are talking about... please
first off, smoking G's of hydro nugs doesn't much compare to this, and with pot, some people do keep getting high, in fact most people do, until they get so high they pass out or they puke (done both, so its from experience). secondly, 8mg is not that high of a dose of bupe, esp when taken as suboxone and by someone who takes it regularly. also, bupe does NOT work by "blocking the dopemead" receptor... there is no dopemead receptor. are you talking about dopamine? it doesn't block that either. bupe is a partial agonist of mu-opiate, and afaik an antagonist of k-opiate (and possibly slightly agonist of delta, but not sure here) receptors. that means that it "partially activates" the mu receptor (and possibly the d) (this is "keeping it simple, just for you") but does not "block the receptor. if you take it after taking heroin, for example, it has a higher affinity for the receptors, so it will "knock" the heroin out, but it doesn't activate the receptors as much, due to its partial agonist abilities, so you actually can induce withdrawels in people that are opiate tolerant, to full agonist opiates. if you are not tolerance at all, then it activates the receptors and gets you "high" (or gives you opiate effects, although slightly different because even though it is working at the mu receptors, every drug acts slightly diff, plus its only a partial agonist). the naloxone only works when injected anyways, but they didn't think muchwhen they put it in the suboxone, because bupe has a higher (much higher) affinity for the receptors than naloxone, so even if you inject it, the bupe goes tot he receptors and locks itself in there and won't let the naloxone in. even if you injected with straight naloxone while on bupe, yo uwould likely feel nothing (whereas if you were high on dope and did that you'd be sick as shit)
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
