Bupe suboxone plugged (rectal buprenorphine)

[evolutionofthemind]

To use another opiate and not have the buprenorphine block it.



Depends. The half-life is 36 hours. So if you take 8mg, 36 hours later there will only be 4mg, and another 36 hours later there will be 2mg, and another 36 hours later 1mg, and so on and so on.

For those of us that use everyday though, it adds up, which is why it's suggested to not dose everyday if you don't have to, or to just stick to low doses (<4mg).

Think about it:

8mg every 24 hours. You dose 8mg the first day. The next day you have ~4mg in you still when you dose another 8mg. So that's 12mg total in your system on the second day. On the third day, you'll have ~6mg in you when you dose another 8mg, so you'll have 14mg in you on the 3rd day. On the 4th day, you'll have 7mg in your system when you dose another 8mg, so you'll really have a total of 15mg, and so on and so on.

See how that can work against you? It's why it's suggested to take lower doses. The lower the doses, it barely builds up at all, and does it at a much slower pace.

I understand the math, but in my reality it's not working like that. Like for instance I plugged a 8mg pill this morning, and not 6 hours later I started to have slight WD symptoms. I sat (twice) with a 2mg nugget under my tongue for probably 30-40 mins praying to all that is holy for it to somehow get into my bloodstream, and things got a bit better. A few hours later I got really dizzy and did the same thing with another 2mg and almost instantly the dizzyness subsided and I started to feel normal again.

I just don't believe the half-life is what it claims to be.

 

[sixpartseven]

The reason I say "~Xmg" (~ means about) is because half-life is not the only factor that contributes to how much drug is in your system. The rate of absorption plays a big role, and can be affected by many things, like method of admin for instance.

The half life is 36 hours. It's solid fact, and no matter what, it will always be 36 hours. Half life is a constant.

 

[evolutionofthemind]

The reason I say "~Xmg" (~ means about) is because half-life is not the only factor that contributes to how much drug is in your system. The rate of absorption plays a big role, and can be affected by many things, like method of admin for instance.

The half life is 36 hours. It's solid fact, and no matter what, it will always be 36 hours. Half life is a constant.

So why am I experiencing WD after only a few hours?

 

[sixpartseven]

*shrugs*

lol sorry. I have no idea why. It doesn't make sense to me.

 

[evolutionofthemind]

it could be because after you get below a baseline dose, say 10mg in your system, your receptors aren't used to feeling empty. in other words, they've adapted to 10mg in your bloodstream consistently throughout the day, and have stopped producing natural endorphins accordingly. when you feel the withdrawals coming on multiple times in a day it is likely due to the fact that you dosed multiple times a day the previous day, so you get a bunch of dips under 10mg, where the WD will pick up to alarm your body that it needs more.

the same thing happens to me. i dose twice a day. i feel the WD in the morning upon waking---lethargy, constant yawning, teary eyes, sneezing sometimes, then again in the evening around dinnertime when i am due to dose again.

What about dizzziness? I feel that before anything else... it's most annoying and troublesome.

 

[sixpartseven]

That's because dizziness is not a symptom of WD.

Are you sure what you are feeling is withdrawal and not just dysphoria from taking too much?

Are you by any chance getting headaches as well?

If you could, evolutionofthemind, list all your symptoms for us.

 

[evolutionofthemind]

That's because dizziness is not a symptom of WD.

Are you sure what you are feeling is withdrawal and not just dysphoria from taking too much?

Are you by any chance getting headaches as well?

If you could, evolutionofthemind, list all your symptoms for us.

Funny... I wasn't dizzy all day (and I've sublingually taken my doses so far), but when I just went and took my last dose rectally it made me dizzy again... could it be that it's the rectal administration is what's making me dizzy?

 

[OpiYum]

Thanks everyone!

I tried rectal suboxone of 4-8mg (forgot) and actually felt a slight mood lift and "heartwarmth". I have never felt anything good from suboxone until the rectal time. My normal daily does is 8mgs.

 

[nottobright]

Just my $.02.....After reading this thread, I decided to go ahead and take 1mg intranasal. To my surprise I actually do have a euphoric feeling. I'm at appx 2mg every other day, so I figured 1mg would be enough, and I was right. Now, maybe I missed this somewhere in this thread, but because I didn't take it the "correct" way, will the effects not work the way they usually do?

 

[chrisinabox]

^not from one time intranasal use no. i believe even if you did it intranasally everyday, sublingual would still work, especially since ur doing double the dose that way. so basically yes you should feel it the same, u just may not feel it as euphoric

 

[evolutionofthemind]

Getalin Capsules?

I saw on a post here about someone saying you could put the crushed suboxone powder into vegetarian/gelatin capsules and then take them rectally that way... just wanted to know if that's true, and if so how successful is it? (BA affinity, etc.)

 

[vicodelicious]

Well, it's been said but I'm still going to add my 2 cents.

Rectal Suboxone works wonders! I am Rx'd 24mg of Suboxone per day (3 X 8mg tab). I am absolutely so sick of the nasty taste of letting those bloody pills dissolve in my mouth, so lately I've been taking my daily dose rectally. Here's what I do:

I go to the pharmacy and ask for a 5 or 10 mL oral syringe. Chance are the pharmacy will not charge you, and just give you one b/c they're so inexpensive. If you're questioned why, just say it's for giving your toddler medicine...
Then I take my dose of 3, 8mg tabs and powder them in a small jar, Fill the syringe with 4 - 5 mL of warm water, and squirt this onto the powered buprenorphine. Mix well and draw this up into the syringe. You should have no problem dissolving 3 or 4 8mg tabs in 5mL of warm water. Then lay on your side and insert the syringe into your bum. Now, you don't have to take the whole thing in your ass like a porn star, but you know, enougth to get the liquid solution in you. I'd say a pinky fingers length should do. Slowly inject the solution and then lay there for a few minutes to let the solution absorb. The longer you can lay there the better it will absorb... and presto!! The buprenorphine should hit you better than sublingually and no nasty taste to deal with!

I actually find this procedure a lot less troublesome than dissolving 3 of those nasty tasting tabs under my tounge. This is a very good method and seems to have no ill affect. Happy plugging!

Vicodelicious

 

[Captain.Heroin]

Yeah, I felt the Suboxone, but whether you had the same results as me or not, the one thing that is for sure is it still takes a few minutes for Suboxone to start working via IV (Subutex is a different story because it does not contain naloxone). This means you do not get a rush, in the true sense of the word at least. Maybe you get a rush, or what you define as a rush, but it's not the typical rush. It can't be. It's impossible.

"A few minutes" is drastically faster than sublingual onset (for myself). The "rush" you get from IV heroin is not the same as IV bupe. I've only IV'd heroin a dozen times (probably a few more than that), I usually snorted heroin. With that being said, the high was elongated, but there was little rush - the lightheadedness, the nod, the euphoria. I get these things from IV bupe. I get lightheaded (somewhat), I start to nod (not present sublingually from what I can tell), I get euphoric (not like crack or cocaine or heroin or anything like that...it's different...but it is there. it has similarities and differences with heroin, but it is clearly different.). I guess when you said "Yeah, I felt the Suboxone," that's exactly what I'm talking about. I feel it better this ROA because it's more effective at least for myself.

Mix some heroin with naloxone and tell me if you get a rush. Mix some oxycodone with naloxone and tell me if you get a rush. You won't, because they cancel each other out.

This is true, because naloxone has a higher affinity towards the receptor, and it will out-compete diacetyl-morphine and oxycodone.

Same with buperenorphine and naloxone. Naloxone temporarily cancels it out, but because buprenorphine has a higher affinity than naloxone, the buprenorphine will eventually win out, but not immediately, and that's why there is no rush.

I'm sorry but you're wrong here, contrary to popular belief, buprenorphine has a higher affinity towards the receptor, and it will out-compete Naloxone. The dose of naloxone is ineffective in suboxone.

If you IV'd suboxone and didn't get a rush, I'd like to know what dosage you tried, and how long you have IV'd heroin (possibly you've desensitized the receptors to the point where buprenorphine simply cannot give you any sense of euphoria). Most people (even non-opiate users) are high within a minute or two from 0.5mg or 1mg iv suboxone. I'm surprised of your results to be honest.

Another factor is - if you try IV 1mg but are used to sublingually dosing 8 or 16 mg a day, it simply isn't going to work for you, you have to get used to being at 2mg/day of suboxone or lower.

 

[evolutionofthemind]

Well, it's been said but I'm still going to add my 2 cents.

Rectal Suboxone works wonders! I am Rx'd 24mg of Suboxone per day (3 X 8mg tab). I am absolutely so sick of the nasty taste of letting those bloody pills dissolve in my mouth, so lately I've been taking my daily dose rectally. Here's what I do:

I go to the pharmacy and ask for a 5 or 10 mL oral syringe. Chance are the pharmacy will not charge you, and just give you one b/c they're so inexpensive. If you're questioned why, just say it's for giving your toddler medicine...
Then I take my dose of 3, 8mg tabs and powder them in a small jar, Fill the syringe with 4 - 5 mL of warm water, and squirt this onto the powered buprenorphine. Mix well and draw this up into the syringe. You should have no problem dissolving 3 or 4 8mg tabs in 5mL of warm water. Then lay on your side and insert the syringe into your bum. Now, you don't have to take the whole thing in your ass like a porn star, but you know, enougth to get the liquid solution in you. I'd say a pinky fingers length should do. Slowly inject the solution and then lay there for a few minutes to let the solution absorb. The longer you can lay there the better it will absorb... and presto!! The buprenorphine should hit you better than sublingually and no nasty taste to deal with!

I actually find this procedure a lot less troublesome than dissolving 3 of those nasty tasting tabs under my tounge. This is a very good method and seems to have no ill affect. Happy plugging!

Vicodelicious

I've done it that way... I want to know if I can use gelatin capsules

 

[pantysweeper]

I have never taken any drug this way. If you are going to take suboxone or another pill this way, how far into your ass does it need to go?

 

[evolutionofthemind]

I have never taken any drug this way. If you are going to take suboxone or another pill this way, how far into your ass does it need to go?

I would assume just as long as it clears the asshole it's far enough, but I could be wrong...

Anyone.... Anyone.........?

Most people (even non-opiate users) are high within a minute or two from 0.5mg or 1mg iv suboxone.

Why would it take minute or two? IVing any other drug the rush is pretty much instantanious....

Also, is that the recommended amount to IV or could you use up to 4-8mg?

 

[Captain.Heroin]

Why would it take minute or two? IVing any other drug the rush is pretty much instantanious....

Also, is that the recommended amount to IV or could you use up to 4-8mg?

There was a study which gave people IV 8mg subutex and suboxone.

I highly do not reccomend IVing 8mg of either - ever at all. You really won't need that much.

I don't know exactly why it takes a minute or two, probably because it's a more subtle effect than mu-agonists. When one shoots heroin, you feel a cold, fluid rush to your head, and you get light headed, and you get really euphoric and feel like you're kind of melting...it's a beautiful feeling. But when one iv's bupe, it's a more subtle feeling, doesn't give you a massive head rush leaving you drooling on yourself (but there is somewhat of a rush nonetheless, the same rush you'd get from sublingually dosing a comparable amount). I have felt iv bupe within 30 seconds (which is usually how fast iv heroin takes to hit me), but due to the fact it's a tad bit more subtle and a lot less euphoric (if I could take bupe to get high I'm sure plenty of people would, but you really can't. It's euphoric to a sense, but if you're on mu agonists, bupe isn't going to do shit to you in terms of a "high", if you're a non-opiate user, it's a different story). The most I would reccomend in an iv of bupe is 2mg TOPS. I would sublingually taper to below 8mg before considering iv bupe, seeing as it has less of the agonist effects at higher doses, iv bupe at a higher dose than 2mg will be a lot less euphoric than below or at 2mg.

You might feel the iv bupe "instantaneous", but it won't be the full effect yet, it will take a while to build up the feeling (as when you shoot heroin, the peak will come on in a few minutes, not instantly as though you were vaporizing crack).

 

[evolutionofthemind]

When one shoots heroin, you feel a cold, fluid rush to your head, and you get light headed, and you get really euphoric and feel like you're kind of melting...it's a beautiful feeling.

Are you referring to black tar here or china white? I've only done black tar (a lot of it) and I never had a rush that sounds anything like what you're describing... it sounds absolutely wonderful though! lol

 

[Captain.Heroin]

Are you referring to black tar here or china white? I've only done black tar (a lot of it) and I never had a rush that sounds anything like what you're describing... it sounds absolutely wonderful though! lol

I used to get brown/white/sometimes tan/grey (not as common) powder/rock heroin (no black tar). The brown was usually better than the white (despite the fact that pure heroin is white), though the grey rocks were also some of the best batches I've gotten (you know, the stuff that's completely firm and you can chip off a good bit without losing too much, nice and gritty while you're crunching it up...) yeah, the iv rush from the stuff was absolutely wonderful, but I wouldn't like to do it anymore. It got out of hand for me and wasn't as fun as occasionally using. I prefer dosing around 3mg or below of suboxone a day and being able to be totally functional instead.

 

[evolutionofthemind]

I prefer dosing around 3mg or below of suboxone a day and being able to be totally functional instead.

Interesting... yea I like to be functional too, but once in awhile I'd like to recreationally get that rush... I just don't know where to go to get the good stuff; the only shit around here is shitty ass tar, and I'd frankly rather do percs or viks that that garbage...