What doses? How high have you gone one bupe? Everyone’s different it’s funny tramadol did absolutely nothing to me. Was like a placebo pill lol
I've been on doses as low as 0.02mcg of bupe to 32mg of bupe over the last 8-10 years or so.
Unfortunately it seems like the higher I go, the less effects I actually get.
I can feel effects up to about 12-16mg, but not if I'm taking that same dose every day. And I'd say the effects are very muted & not as enjoyable as other opioids.
Most days it's pretty imperceptible, except for the feeling of "coming back to feeling normal" and the sedation that follows.
Yeah tramadol is a hit or miss drug for a lot of people. I think a lot of people don't have the right liver enzymes to convert tramadol into it's active metabolite, O-desmethyltramadol.
Of course tramadol is not very potent either & some of the prescribed beginning doses for tramadol are ridiculously low. I use to need anywhere from 200-400mg in a stacked dose to really enjoy it, even with no tolerance. So I'd imagine anyone trying trams who only takes a pill or two is gonna probably be disappointed. I was "addicted" (I hate that word, cause it makes it sound like a bad thing) to tramadol for 11 years. It helped me be more physical, felt more content, more confidence, made working easier, etc.. It also gave me nods similar to heroin & even itching (which I enjoy). I'd rub my nose red from the itching but I liked it cause it just meant I was feeling pretty damn good. lol
But I never get itching or that fully content feeling from buprenorphine. Bupe had an okay "high" in the beginning, I compared it to tramadol because it would start off very stimulating, made me chatty, made me pretty relaxed & have less drug cravings over all. That stimulating characteristic was very reminiscent of trams or a lite-heroin buzz. But unfortunately this effect started rapidly diminishing with daily use, no matter my dosage. And it takes an incredibly long time to wait for bupe to leave your system so that your tolerance will drop. But with tramadol, the high would also kinda diminish with daily use, but it still helped my depression & pain in a better way I think.
Actually I think low doses of bupe + tramadol is superior than using either bupe or tramadol alone. lol Bupe provides that heavy morphine-like opiate feeling, while the trams provide that "fully content" feeling, along with more motivation/energy/creativity. Bupe doesn't make me feel very creative like other opioids do either unfortunately.
Of course when I was using heroin, tramadol didn't do jack shit besides keep me slightly out of withdrawal. So tolerance can play a huge role too in whether or not tramadol will be enjoyable.
I believe I read that even though buprenorphine has a 36+ hour half-life, the analgesic properties only last about 4hrs.
A bupe "high" or just the effects of a normal day of taking bupe for me, starts off with about 2-4hrs of feeling "normal", a little more energy, less pain, etc.. And then after hour 2-4, I start to just get really sedated & sleepy (bupe has a metabolite that is a sedative, but not a mu-agonist, so I think this metabolite might be why bupe seems so much more sedating to me than other opioids but this is just a theory of mine).
I actually got to do some tramadol a few weeks ago, after not having any for a long time. And it felt wonderful. It was like something in my brain woke up from an ancient slumber & I suddenly felt alive again, grateful, comfortable, creative.... But I never get any of that from bupenorphine, at least not anymore.
Shit I wish there was some easy at-home chemistry to turn bupe into a full agonist or something. I know it's possible but you'd need lab grade equipment & chemicals not accessible to your every day person.
As much as I knock buprenorphine though, I do think it's a great semi-synthetic tool for various purposes & an interesting compound. I just wish it gave a little bit better euphoria (which would also translate into better analgesia as well... as much as the medical field wants to act like euphoria is an unwanted side effect... it's actually the euphoria that's helping people not be focused on the pain. Plus for some one who's miserable everyday due to treatment resistant depression, feelings of "well-being" are very much a reprieve).
