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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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Hm.. Do you feel these symptoms all the time, or just later in the day, after you dose your suboxone? It might help to break up your dose so that you do 1/2 in the morning and the other 1/2 in the evening. This would probably help if you only feel these withdrawal symptoms towards the end of the day.

I you're feeling the withdrawals symptoms pretty much all of the time, regardless of how long it's been since you took the suboxone, than you're kind of out of luck. The thing with suboxone is that it is a partial agonist as you may know, so it's opiate effects plateau after a certain dose (and IME, and the experiences of many others that I know, this 'ceiling effect' occurs somewhere around 4-8mg). However, the good news is that you have not been taking the suboxone long enough to stabilize on it. After about 1 1/2-2 weeks you should be more or less adjusted to the suboxone and you won't experience those withdrawal symptoms anymore. Suboxone has a long half life which builds up on itself over time (see image below):

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I like this chart because it shows how the half life of suboxone builds up on itself in a linear fashion until it stabilizes at day 11. Once you've gotten to this point, the cool thing about suboxone is that as long as your above the cieling effect, it doesn't really matter how much more or less you take (so basically, 16mg and 32 are the same-the only difference is the ammount of time it takes after dosing for buprenorphine levels to lower beneath the cieling dose, at which point withdrawals are felt).

However, if your thinking of being on suboxone for maintenance, I wouldn't really recomend taking anymore than 8mg/day, and I've always preferred low dosages (4mg and under) as the stimulating effects of buprenorphine are more drastic.
 
Hello,

I've a question to ask about subs which has no doubt been asked somewhere else within the bowels of this thread, so apologies if that is the case.

I'm not an opiate/oid addict, but do enjoy occasional use. At the moment my tolerance is non-existent. I bought some temgesic pills about a month ago, but alas was too high to bother to make a note of the dose. About 8 of these pills gave me a decent nod with no tolerance. If I could find said pills again, I'd buy, but unfortunately I can only find 8mg suboxones and subutex being sold. I understand that with no tolerance very little of one pill would make the user very sick. Has anyone in a similar situation found it easy enough to get nicely high without being ill using an 8mg pill, or are the chances of overdoing it too great to make it worthwhile?

Thanks in advance.

Edit: I should clarify that by 'using an 8mg pill' I don't mean taking a whole one and being fine, but splitting the pill up / making a solution / etc. Sorry if that wasn't obvious. And sorry if it was and intelligences have been insulted.
 
I have a quick question. I have been on suboxone for 10 months now. I'm on a daily dose of 1.5mg a day. I got a really bad cold right now and I was going to take some tussi cough med that has codeine in it. Just wondering if would make me sick taking it? or will I be ok? to take it.
 
I have a quick question. I have been on suboxone for 10 months now. I'm on a daily dose of 1.5mg a day. I got a really bad cold right now and I was going to take some tussi cough med that has codeine in it. Just wondering if would make me sick taking it? or will I be ok? to take it.

IMO I doubt it will hurt on that dose. However, it is an individual thing. Personally I'm on the same dose and I can take opiates 24 hrs after dosing and feel most of the good effects. Then I wait about 24 hrs after the opiate dose to take subs and I'm fine. My advice is to wait the 24 hrs and take the Tuss and see how long that holds you and when it wears off, decide if the benefits are worth the effects and proceed from there.
 
I have a quick question. I have been on suboxone for 10 months now. I'm on a daily dose of 1.5mg a day. I got a really bad cold right now and I was going to take some tussi cough med that has codeine in it. Just wondering if would make me sick taking it? or will I be ok? to take it.


if you take the codeine AFTER taking bup, you will be fine, and you even be fine the the next time you take bup because bup stays in your system a long time, and if you are on maintenance the sub will start to accumulate after a week or two.
 
thanks for the answers. I didn't think it would hurt but wasn't for sure. I can't stop coughing from this cold and the tussi ac really helps with that. I really don't care if I get any buzz from the codeine "would be nice though" I just want to get rid of this coughing. Thanks again.
 
Hello,

I've a question to ask about subs which has no doubt been asked somewhere else within the bowels of this thread, so apologies if that is the case.

I'm not an opiate/oid addict, but do enjoy occasional use. At the moment my tolerance is non-existent. I bought some temgesic pills about a month ago, but alas was too high to bother to make a note of the dose. About 8 of these pills gave me a decent nod with no tolerance. If I could find said pills again, I'd buy, but unfortunately I can only find 8mg suboxones and subutex being sold. I understand that with no tolerance very little of one pill would make the user very sick. Has anyone in a similar situation found it easy enough to get nicely high without being ill using an 8mg pill, or are the chances of overdoing it too great to make it worthwhile?

Thanks in advance.

Edit: I should clarify that by 'using an 8mg pill' I don't mean taking a whole one and being fine, but splitting the pill up / making a solution / etc. Sorry if that wasn't obvious. And sorry if it was and intelligences have been insulted.

Temgesic comes in 0.2mg, so if you took 8 of them then you took just over 1.5mg. If I were you I would aim at taking 1mg by quartering the pill into 2mg pieces, and then taking half of one of the pieces. If you get the strips then quarter the strip and break one of the pieces in half and take it.

0.5mg might be a better dose, so try that amount and see how you feel in an hour, and then take the other 0.5mg if you think you need it. The half-life of suboxone is so long that you can add onto your dose pretty effectively since the first part of the dose won't have started wearing off at all. For me it actually takes close to 3 hours before I feel the peak effects of suboxone when I take it sublingually.
 
Switched to suboxone films yesterday and seeing as I always snorted my tablets, I thought I'd dissolve the films into a nasal spray and use that. Takes a bit longer to prepare than the tabs, but I'm sure that will speed up once I get used to it. But I'm liking it. Was just laying on my bed today, not expecting anything, and then I notice that I'm starting to feel euphoric. Hadn't felt that way on subs for almost two years, so it was a nice surprise - thought I'd lay in bed for a bit longer. ;) I'm thinking the films are gonna be a "healthier" way to take intranasally, not getting all that stuff in your lungs.
 
I was wondering if anyone who's on Suboxone and relapsed has told their doctors? I want to, because I've been doing H again after having cravings and dreams, but I'm afraid that he'll just kick me out. I've been on 8mg/day since last August (2011) and only ran out early 1 time (that he knew about). I don't know if my dose isn't high enough or if I would be better off going back on methadone. Although, given my history of relapsing, I've learned enough to know that the problem is ultimately with me, and my tendency to get bored after not using my DOC for so long.
Anyways, I know I digressed quite a bit; but I really just wanted some advice on how to handle the relapsing and whether to tell my doctor. I just don't want to get cut off and be completely SOL. Thanks, everyone! I've spent many late nights on this site!

It honestly depends on the doctor. Does your doctor give you frequent UA's? I relapsed after about 4 months, and I was "sneaky" and only used certain days so that I would pass my UA. Soon enough, I found myself using every day, and couldn't pass that UA anymore! I was honest with my doctor..I told him everything. What he did was keep prescribing me the Suboxone, but as I continued to use, he told me to seek out MORE care, like treatment. I needed treatment, anyway, so I took his suggestion.

Your doctor probably has a different policy than mine, but who knows? It's hard to say. Did you sign any type of contract when you started with him? If you did, ask if you can get a copy of it and try to find out about the policy dealing with a relapse. In MY opinion, I would just be HONEST! That's me, though. I've found that honesty will get you so much farther!
 
I don't know if this is the right place for this, I apologize if this is wrong. I just started a clinical trial for a new kind of Bupe that's not on the market yet. I was wondering if anyone else is in the study here. I would love to talk to someone else who is in it. It's the BEMA Buprenorphine NX study. It's Bupe+naloxone in a patch form that sticks to the inside of your cheek and dissolves into the buccal mucosa. It's amazing!!! I love it so much better than the pill. It hits faster, stronger, and keeps longer. With the pill I can always feel when it's time to dose again, with this buccal patch I don't get that feeling. I can't wait until this hits the market (if the study goes well, which I have a strong feeling it will). It has a citrus flavor (or what's supposed to be citrus)....it tastes like a kid's fluoride at the dentist. I will be very sad when this study ends and have to go back to taking the under the tongue pill.


Hopefully I can hear from someone else who is in the study somewhere else (I know there are multiple sites doing this across the USA)! Also, if anyone has any questions I would be glad to answer them.

Here's a link to the clinical trial gov. site: http://clinicaltrials.gov/ct2/show/NCT01666119

Here's a link to what it looks like and some info about it: http://www.bdsi.com/BEMA_Technology.aspx

Wow, that's really good news! I wonder when this new Bupe would be available to us ORT patients?! I'm sure they didn't tell you much regarding that, but I hope it comes out soon! This sounds too good! I would definitely want this!
 
From the sound of the study (if you follow the link) it sounds like its for opiate dependency treatment which is real cool (btw, awesome to see you again XTCake!). I find the dosages that it is given in really interesting (3.5/.6mg and 5.25/.9mg)... Makes me wonder about the BioAvailibility. Also, I wonder if the onset is more rapid, as well as if the duration of effects is longer. My one problem with suboxone was that I always felt that I needed to split my dose in two. It would be awsome to just stick something in my mouth and not have to worry "shit! Five more hours till I can re-dose!"

Anyway, if anyone has more info, I'd love to hear about it, my goal is to get back on suboxone within the next couple of months if the whole methadone thing doesn't work out for me.
 
My doctor gave me the option to switch from suboxone to subutex. I simply told her the nalaxone was causing head aches and said she'd be able to put me on subutex. Has anyone had the experience of trying both? If so, what are some of the pros, cons?
 
My doctor gave me the option to switch from suboxone to subutex. I simply told her the nalaxone was causing head aches and said she'd be able to put me on subutex. Has anyone had the experience of trying both? If so, what are some of the pros, cons?


There's not much of a difference really, other then if the naloxone really was causing headaches as it does in some people. But, people think with subutex that they can use and have no PW's, etc.. That's not true. It's the bupe itself that blocks full agonists and causes precipitated withdrawals, not the naloxone. At only 2mg's, taken sublingually, it's barley even active.. It's the bupe that causes all that shit because of its incredibly high affinity rate on your receptors.
 
Re: buccal patch. I thought this was interesting, from the second link.

http://clinicaltrials.gov/ct2/show/NCT01666119

Exclusion criteria
7. Use of any medication, nutraceutical or herbal product with CYP3A4 inhibition or induction properties within the past 30 days (see Appendix 4 for a list of applicable drugs). This exclusion also extends to grapefruit juice and grapefruit juice-containing products as well as St. John's wort and St. John's wort-containing products (prescription or nonprescription drugs, vitamins, minerals, or dietary/herbal supplements).
 
Happy Thanxgiving everyone. I have a question that someone may be able to help me out with. Been on subs for 3yrs. Havent done ANY other opiate since. I get the 8mg film and the past couple days have been IVing them. No more than 2mg at a time. I've done my homework before hand as I have never IV'd anything. My question is how many units of water do i need for a 1mg piece? I've read ppl on here saying as much as 90 units which i think is way too much. I only have a 50 unit rig and dont like having to fill the entire thing because i have no room for drawing back. I would like to hear from captain h but any responses would be appreciated.
 
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