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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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syntheticbreakfast said:
Hi guys, I'm thinking about combining buprenorphine with pregabalin this weekend, and I'm wondering if anyone has any insight on this combo. I have no tolerance to either drug, and I plan to take between 0.25 and 1 mg of buprenorphine with between 450 and 750 mg of pregabalin. Does anyone know how safe this is? I have taken 6 mg of hydromorphone with 300 mg of PGN before, but I didn't dose the PGN until the hydro was starting to wear off.

I did make a separate thread about this, but I thought I might have more luck here, so I'll just check both for now. Feel free to ignore this post and reply in my thread instead. http://www.bluelight.ru/vb/threads/646754-Buprenorphine-and-pregabalin
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In the future make one post for the same question, don't make a thread and advertise about it in other threads. The reasoning for this is that Bluelight is run on donations, and double posting things wastes our precious bandwidth, it also make's the moderators job more difficult regulating and more importantly it's a rule, so it doesn't really matter why just figured I'd let you know anyway.

Secondly, don't take 1mg of bupe without a tolerance. No need for it. Wont be "dangerous", but could make you feel like shit. take .25. as far as the PGN I've never used it so I don't wanna try and make up an answer, nor do i wish to do the research for you at this time. Good luck.
 
caseface99 said:
In the future make one post for the same question, don't make a thread and advertise about it in other threads. The reasoning for this is that Bluelight is run on donations, and double posting things wastes our precious bandwidth, it also make's the moderators job more difficult regulating and more importantly it's a rule, so it doesn't really matter why just figured I'd let you know anyway.

Secondly, don't take 1mg of bupe without a tolerance. No need for it. Wont be "dangerous", but could make you feel like shit. take .25. as far as the PGN I've never used it so I don't wanna try and make up an answer, nor do i wish to do the research for you at this time. Good luck.
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Sorry about that, I didn't know. If a mod wants to fix it (by deleting my post) I'm sure they will.

I've done it before, so I know what taking 1 mg of bupe without a tolerance is like, but thanks anyway. .25 is okay, but I don't really see why .5 would be bad...

Has anybody taken bupe with PGN?
 
Don't be sorry, just a tip. ;)


And that's good you know your bodies natural tolerance already, I just wasn't sure. I've seen people get the "too high" sort of ill feeling for an entire day off of a mg of bupe.
 
I have, as well as taken bupe with gabapentin-however, I was on suboxone maintenance, though I was only taking .5mg 2x/day (so I was getting euphoric effects still out of the bupe). If you have no tolerance I really wouldn't bother adding the Lyrica as IME both pregabalin and gabapentin only intensify the body high of opiates (and some of the nodd as well). If you have no tolerance than I would imagine .5-1mg of buprenorphine would have you feeling good enough by itself. I guess I just feel that it's pointless to potentiate/synergize opiates with other drugs if you don't have the tolerance. I suppose though, if you really like the way pregabalin works, than it makes sense, just lower your normal dosage.
 
Znegative said:
I have, as well as taken bupe with gabapentin-however, I was on suboxone maintenance, though I was only taking .5mg 2x/day (so I was getting euphoric effects still out of the bupe). If you have no tolerance I really wouldn't bother adding the Lyrica as IME both pregabalin and gabapentin only intensify the body high of opiates (and some of the nodd as well). If you have no tolerance than I would imagine .5-1mg of buprenorphine would have you feeling good enough by itself. I guess I just feel that it's pointless to potentiate/synergize opiates with other drugs if you don't have the tolerance. I suppose though, if you really like the way pregabalin works, than it makes sense, just lower your normal dosage.
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Thanks for the reply! I think I'll still combine them, because I love PGN by itself too, and it seems to go well with most things. With pregabalin and cannabis, I get vivid hypnagogic-like closed eye visuals (that can even turn into full-blown dreamlike states, at higher PGN dosages), and I also get hypnagogic-style imagery when I'm relaxing with eyes closed on opiates. So I'm curious about what kind of closed eye visuals combining all three would produce, and that's why I'm going to do it. I think I'll just take a lower dose of each drug and see how it goes, as you suggested.
 
Went thru with my plan.Day 1 of no Suboxone. (I went on an oxy binge for 2 weeks to get Bupe out of my system and used the sub for the oxy wd , discontinued after the 4 days)

Suprisinly don't feel as shitty as I usually do in the morning before I use to take my dose
 
The problem is when you stop any medicine when your on Subutex or Suboxone, you still feel its side-affects, or some orm of withdrawals. Ive taken valium and other benzos, gabapentin, zopiclone, even opiates and I always felt some withdrawals the next day or whenever I stopped taking them, even if I took them once or every now and then. Thats why I also feel comfort meds will not be good mentally for sub users when they detox from sub, your mixing their withdrawals with sub withdrawals and it doesnt do yourself any favors, you feel even worse.

The bup withdrawals can creep up after 3 weeks, the mental withdrawals can creep up after 4 weeks, the bup is very stick to the receptors so watch out and be-careful about that aspect. Its a reason why many sub users claim PAWS and some withdrawal symptoms creep up after a very long time since stopping bup. The longer you take bup the longer it will take for the withdrawals to reach their peak. 1 day or 1 week is not even the beginning of bup withdrawals, trust me on this. If people feel fine after couple of days then its because of the bup is still in-play in your bodies and receptors, when it slowly comes out thats when you start to feel terribly bad granted.
 
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^Sorry, but I don't agree with that. IME and almost every other person who I know that has kicked bupe at some point, the withdrawals really hit you hard by day 3 and 4, even if you quit CT from a high dose like 16mg and upwards. If you've stopped taking suboxone or buprenorphine for a week and don't feel withdrawals than you either have a very S L O W metabolism, or you've been taking 32mg/day or more (and even then I'd imagine you'd be feeling pretty shit by day 4 at least..)

Now if you're talking about post acute withdrawals, than yeah, but acute withdrawals will start within the first week for sure, no matter how long you've been on suboxone, or what dose you were taking.
 
Alright, I have a reallly quick question: I usually take like .5mg-1mg suboxone a day IV (honestly it's probably less than that.. I don't exactly measure it out..) but for the last week I've only been able to literally scratch a tiny bit off an 8mg pill for one single shot per day.. I don't even know if I could measure how little this amount is.. and On friday night (today is Thursday morning) I would like to do some IV morphine, my question being is this enough time to feel the effects? I'm not really familiar with morphine at all. Afterrrr, how long should I wait to dose my subs again, when I'm withdrawing?
 
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IV bupe question

ok so I usually IV .25mg of bupe a day, how much would that equal to if I were taking them the way you are supposed to? and how long do you think I would have to wait to feel 200mg of hydrocodone?
 
Sublingual buprenorphine has a BioAvailibility/absorption of approximately 30%.

Therefore, .25 IV would be around 1mg sublingually. However, you have to take other factors into consideration, such as, when buprenorphine is injected intravenously, it begins to get metabolized (eliminated) immediately. When you take an equipotent sublingual dosage, it takes up to several hours for the buorenorphine to reach its peak plasma level's (which is when the body then proceeds to start the slow process of elimination). This is the reason why IV Bupe seems so much sorter acting in duration.

When I used to inject suboxone, I got down to using .1-.2 mg / shot. However I ended up doing 3-6 shots a day, which made it very similar to shorter acting IV opiates. The half life was still longer than heroin, but let there be no doubt about it, If I went 12 hours between shots I definately began to feel withdrawals. For this reason I eventually switched back to sublingual ROA.

Also, while the only 30% of buprenorphine is absorbed sublingually (making 1mg equal to about .3mg IV), you can dose the 1mg SL once a day and be fine, yet like I said above, when injecting, most people fix at least two times/day. So you cannot really compare them in a logical way, as I remember I once had to stop injecting my suboxone for a week and switch back to sublingual. I had been shooting .9 mg/day (~3mg SL), and instead of taking 3mg sublingually (taking the equivalent dose of all my shots combined), I instead took only 1mg 1x/day or .5 2x/day, and it held me perfectly. So when you convert Iv to sublingual, your daily dose of SL buprenorphine will be closer to one of your intravenous dosages, rather than the equipotent dose of all your IV Bupe that you do in a day.

A for the hydrocodone.. I wouldn't bother. right now Bupe probably is not blocking your receptors (unless your shooting .25mg like, ten times a day). However, it has raised your tolerance. The lowest doe of a full agonist that I could get high off of when I was shooting .5mg of suboxone/day was 30 mg of oxycodone.

With that Ill merge this with the Suboxone/Bupreorphine Megathread and FAQ.
 
well I only shoot it once maybe twice if im in a lot of pain but for the last 4 days straight I have only shot .25 once a day, and if you say you got high off 30mg's of oxy why would you tell me to not bother? oxy is only 1.5 times as potent as hydrocodone
 
I forgot to mention I shot the oxy, felt buzzed for a little while (15 minutes top), then shot the other 30mg. It really took the whole 60mg to get me where I wanted to be, I just meant I felt the oxy at that dose.
 
Znegative said:
Sublingual buprenorphine has a BioAvailibility/absorption of approximately 30%.

Therefore, .25 IV would be around 1mg sublingually. However, you have to take other factors into consideration, such as, when buprenorphine is injected intravenously, it begins to get metabolized (eliminated) immediately. When you take an equipotent sublingual dosage, it takes up to several hours for the buorenorphine to reach its peak plasma level's (which is when the body then proceeds to start the slow process of elimination). This is the reason why IV Bupe seems so much sorter acting in duration.

When I used to inject suboxone, I got down to using .1-.2 mg / shot. However I ended up doing 3-6 shots a day, which made it very similar to shorter acting IV opiates. The half life was still longer than heroin, but let there be no doubt about it, If I went 12 hours between shots I definately began to feel withdrawals. For this reason I eventually switched back to sublingual ROA.

Also, while the only 30% of buprenorphine is absorbed sublingually (making 1mg equal to about .3mg IV), you can dose the 1mg SL once a day and be fine, yet like I said above, when injecting, most people fix at least two times/day. So you cannot really compare them in a logical way, as I remember I once had to stop injecting my suboxone for a week and switch back to sublingual. I had been shooting .9 mg/day (~3mg SL), and instead of taking 3mg sublingually (taking the equivalent dose of all my shots combined), I instead took only 1mg 1x/day or .5 2x/day, and it held me perfectly. So when you convert Iv to sublingual, your daily dose of SL buprenorphine will be closer to one of your intravenous dosages, rather than the equipotent dose of all your IV Bupe that you do in a day.

A for the hydrocodone.. I wouldn't bother. right now Bupe probably is not blocking your receptors (unless your shooting .25mg like, ten times a day). However, it has raised your tolerance. The lowest doe of a full agonist that I could get high off of when I was shooting .5mg of suboxone/day was 30 mg of oxycodone.
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Thanks for clearing that up! I was wondering the same thing. I was afraid that I would be stuck having to shoot my dose all the time and keep messing up my veins.
 
How to bypass Suboxone and get high

My friend did her last shot at around 9pm and that night started withdrawing at around 3am. She took a suboxone (2mg) at 5:20 AM and it sent her into precipitated withdrawal. It was terrible from her description she was on the verge of killing herself! she then scored at around 10am and banged three bags, it gave her a semi rush but the high faded soon enough. My question is now that she is feeling slightly better than okay, if she does more will she feel the effects more? Any posts will be helpful. thank you :)
 
This isn't a Trip Report. Trip Reports --> Other Drugs.

If she does more of what? The Suboxone or heroin?

I'm going to merge this into the Suboxone Megathread.
 
^ You could try to source bupe from another country (maybe India, where it is everywhere). It may be more expensive as they come in lower doses, but at least it will be consistent.
 
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