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OD Moderators: Keif’ Richards | negrogesic
Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022
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Material541
Bluelighter
According to the first page of this thread:
intramuscular: 68%
"The observed mean intramuscular bioavailability was 68%"
"Studies of buprenorphine bioavailability have also examined the intramuscular (bioavailability, 50%–100%)"
Question
I have been on Methadone for 12+ years. I switched to heroin when I got a hook up in town earlier this year. When I dont have H or Dones I will take anything and everything to get through to my next hookup. I Prefer to IV what I can and I dont use no micron filter (I know I should Capt. H). Earlier this year I got my hands on some subutex pills and shot a whole pill but I cant remember the dosage, but I liked it!
Since then I have shot 12mgs of Suboxone once, and got pws like I was dying. Since then I am extreme about waiting until im jumping out of my skin to take anything. The last time I had some Suboxone I iv'd 4mgs in the early AM, and took another 4mgs under my tongue later that day. I didnt like the way it felt at all. It felt like all the bad effects of crank. Strung out. I wasnt withdrawling though.
So, after reading all the information I can here (BL) I think what my problem is, is that im taking too much. Last night I took 2mgs Suboxone under my tongue and I also took 600mgs of neurontin, and 2 mgs of Ativan. I woke up feeling good this morning...but I want MORE.
My question is: I hear lots of folks getting high off suboxone. What do I need to do? Iv, plug, snort? How much? I got an 8mg Suboxone strip and 1/2 of an orange hexigon shaped Suboxone pill (4mgs) to work with.
Also was I right about taking too much?
I have been on Methadone for 12+ years. I switched to heroin when I got a hook up in town earlier this year. When I dont have H or Dones I will take anything and everything to get through to my next hookup. I Prefer to IV what I can and I dont use no micron filter (I know I should Capt. H). Earlier this year I got my hands on some subutex pills and shot a whole pill but I cant remember the dosage, but I liked it!
Since then I have shot 12mgs of Suboxone once, and got pws like I was dying. Since then I am extreme about waiting until im jumping out of my skin to take anything. The last time I had some Suboxone I iv'd 4mgs in the early AM, and took another 4mgs under my tongue later that day. I didnt like the way it felt at all. It felt like all the bad effects of crank. Strung out. I wasnt withdrawling though.
So, after reading all the information I can here (BL) I think what my problem is, is that im taking too much. Last night I took 2mgs Suboxone under my tongue and I also took 600mgs of neurontin, and 2 mgs of Ativan. I woke up feeling good this morning...but I want MORE.
My question is: I hear lots of folks getting high off suboxone. What do I need to do? Iv, plug, snort? How much? I got an 8mg Suboxone strip and 1/2 of an orange hexigon shaped Suboxone pill (4mgs) to work with.
Also was I right about taking too much?
Bojangles69
Bluelighter
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OMG I had no idea you could shoot sub IM that is great news! (for some reason I thought you couldn't IM sub) I've been looking for a way to get a higher BA and pluggin although great in potency gives me horrific headaches. IV I just can't grow the balls to do. But IM I am very familiar with from my steroid days so I can't wait to give this a shot.
I have been snorting my sub lately and have found yeh it works great, and better than SL, but it is impossible to do if you're in a rush (like waking up and having an hour to get to work it takes 30mins alone to snort it properly) so I am very psyched now to get my filters and start doing IM.
Can I ask someone though can I filter my suboxone same way I would filter say testosterone propionate? I mean all you do is mix everything sterile than filter it right? I am use to using benzly alcohol and grapeseed oil as a solution though do I mix any type of preservative with the bacteriostatic water? Or can it sit with the sub in it on the shelf for a while? Or maybe I should put it in the fridge instead?
I have been dying to get a quick 1-2 way of getting my sub into my body with a high BA but refuse to shoot anything into my viens. Have no issues going into a muscle though if I go in 1.5 inches deep (how long my syringes are) I can just shoot it right into my ass and be good right?
Any info on IM injection would be really helpful. RealI really just don't get what is in bacteriostatic water that will preserve the sub or if I have to add a preservative to it like I have to do for my steroid oils. Thanks!
I have been snorting my sub lately and have found yeh it works great, and better than SL, but it is impossible to do if you're in a rush (like waking up and having an hour to get to work it takes 30mins alone to snort it properly) so I am very psyched now to get my filters and start doing IM.
Can I ask someone though can I filter my suboxone same way I would filter say testosterone propionate? I mean all you do is mix everything sterile than filter it right? I am use to using benzly alcohol and grapeseed oil as a solution though do I mix any type of preservative with the bacteriostatic water? Or can it sit with the sub in it on the shelf for a while? Or maybe I should put it in the fridge instead?
I have been dying to get a quick 1-2 way of getting my sub into my body with a high BA but refuse to shoot anything into my viens. Have no issues going into a muscle though if I go in 1.5 inches deep (how long my syringes are) I can just shoot it right into my ass and be good right?
Any info on IM injection would be really helpful. RealI really just don't get what is in bacteriostatic water that will preserve the sub or if I have to add a preservative to it like I have to do for my steroid oils. Thanks!
i are spectre
Bluelighter
User X: the high from buperenorphine is not like that of methadone or dia-morph. the best method i have found to achieving what most would call a high is by taking small doses of 1 to 2mg every 4-6 hours. after i have done more than 8mg in one day i get those nasty side effects you're referring to. try to keep doses at no more than 2mg, a 4mg single dose for me makes me feel... altered, in a strange way that is not appealing.
Which method do you use? Iv,plug,etc. I have read SO MANY posts that I couldnt say which people prefered. Im experimenting with iv right now. I have pill form and strip form to use. Is there a difference there? I see your in the midwest. Im in Portland Oregon. Thanks for responding!
i are spectre
Bluelighter
yeah the midwest, but not by preference, just finishing up school here.
i've always used sublingual since i was prescribed the strips, which i no longer have a prescription for right now. as far as feeling euphoric-ish, i liked insuf'd 8mg sub tabs, but only 1-2mg doses. any more and you feel shitty and have to wait like 8-12 hours for it to clear out.
be careful, once you get hooked on subs... well, it's not easy getting off. i've tried for two years, this is around day seven without bupe.
i've always used sublingual since i was prescribed the strips, which i no longer have a prescription for right now. as far as feeling euphoric-ish, i liked insuf'd 8mg sub tabs, but only 1-2mg doses. any more and you feel shitty and have to wait like 8-12 hours for it to clear out.
be careful, once you get hooked on subs... well, it's not easy getting off. i've tried for two years, this is around day seven without bupe.
Again thanks for the information. I have an opiate problem in general. I usually do Methadones or Heroin, but when I cant get that I have always had the option of Suboxone. I only recently started messing with subs. I learned the hard way that more is not better (ivd 12mgs). I think I will try snorting today. Do you use a scale to weigh out your 1-2mg doses? Do you just eyeball it? BTW congrats on 7 days without! I know how hard it is. I struggle everyday to maintain.
Material541
Bluelighter
Finally took the effort to calculate the amount of subs and saline solution to create a nasal spray. Didn't want to make it too concentrated in fear of it not dissolving fully. I settled at 2.5mg per mL. Using my nasal sprayer, I need 4 sprays to get 1mg of suboxone. So much better than having to individually dissolve every dose, which is what I had been doing.
Captain.Heroin
Bluelight Crew
Check out the micron filtering mega thread, it will have all the information you need.
Um I'm sorry if this has been covered in one of the many megathreads.But I am now on Bupe everyday(though am taking a couple of days off to enjoy some full agonists) which sucked, becuase I IV; it wore off MUCH faster then I expected, and had some pretty nasty WD's within 24 hours of my last injection, which I honestly did not expect, and did not even have my full agonists to cover yet!!!
But anyway, I was wondering about the metabolite, norbuprenorphine, and specifically, whether or not taking st. johns wort can really give you what resembles a full agonist experience???
Again, I am sorry if this has been covered, but have searched and have found practically NOTHING. Basically, I just wanna know if it is feasible to use a "heroic" dose of st johns wort to get a high norbuprenorphine yield, or if buprenorphine itself will simply block it.
It supposedly works by inducing cyp3a4 to convert more to norbupe. My problem is, even if it COULD increase the norbupe yield, the liver would still need TIME to metabolize, no matter how high your cyp3a4's are functioning, meaning by the time you had said norbupe, bupe would be attached and would (mostly) antagonize it.
So please, if anyone knows anything about this, your wisdom would certainly be appreciated. Perhaps more importantly, WTF does norbupe do, assuming you manage to get some to attach to your recpetors? I mean I know it is a full-agonist, but what could I expect?
To be honest I usually use tagamet and other p450 inhibitors with my subby, as it makes my IV use even more intense, and it lasts longer, which I found out accidently when I got caught without my inhibitors a couple of weeks ago. So I could be wasting my time, but I am VERY curious...
But anyway, I was wondering about the metabolite, norbuprenorphine, and specifically, whether or not taking st. johns wort can really give you what resembles a full agonist experience???
Again, I am sorry if this has been covered, but have searched and have found practically NOTHING. Basically, I just wanna know if it is feasible to use a "heroic" dose of st johns wort to get a high norbuprenorphine yield, or if buprenorphine itself will simply block it.
It supposedly works by inducing cyp3a4 to convert more to norbupe. My problem is, even if it COULD increase the norbupe yield, the liver would still need TIME to metabolize, no matter how high your cyp3a4's are functioning, meaning by the time you had said norbupe, bupe would be attached and would (mostly) antagonize it.
So please, if anyone knows anything about this, your wisdom would certainly be appreciated. Perhaps more importantly, WTF does norbupe do, assuming you manage to get some to attach to your recpetors? I mean I know it is a full-agonist, but what could I expect?
To be honest I usually use tagamet and other p450 inhibitors with my subby, as it makes my IV use even more intense, and it lasts longer, which I found out accidently when I got caught without my inhibitors a couple of weeks ago. So I could be wasting my time, but I am VERY curious...
Sobobuser89
Greenlighter
Loss of magic, so to speak.
Lemme just give quick background;
I'm 20 years old, male, about 140-150
Started doin sub recreationally last year with little bumps probs 1/10th of a mg. Fell in love
I never got the ridiculous euphoria with other opiates, vik, fent, oxy etc. Which I never understood.
Well eventually I wasn't getting high anymore (not what i mean by loss of magic) and found myself addicted.
Stayed maintained on my doses of >1mg for like 9 months.
Tried detoxing probs 4 or 5 times and everytime ended up going back and getting high. (succesfully i may add!!)
My most recent detox attempt was succesful, in terms of acute withdrawals. I was 12 days clean and for the most part (except for day 5) Ive been dealing with PAWS quite well. On to my question...
Ok, on day twelve off sub I decided I could probs reward myself by getting high once and flush the rest of the strip/film. Well I did probs half a mg (dissolved into water in a spoon and "snorted") well I began to feel the warm rush and talkativeness but then I got crazy sick, puking all night a total of probs 30+ trips to the toilet (most just dry heaves). You may say "well, obv. you did too much" which would make sense but even when I would do too much before I would get completely anihilated(sp?) and maybe one or two pukes and i was fine. Next night me and my girlfriend scored some killer molly, and molly will not work in w/ds or paws, for me at least. So I (blinded by the theory that I did too much the day before) did THE TINIEST little piece of strip, honestly no way to express it in mgs, and I got just as sick (although snortin the molly helped tremendously lol)
In summary (and I apologize for rambling, and for spelling/grammer errors as I am on an iPod)
My question is, did my body, given the multiple detoxes, reject the suboxone? And sort of punish me?
Or,
Is something else to blame? Possibly naloxone? Doesnt seem likely to me..
I thank all for reading through and appreciate all replies.
Also bluelight is such a wonderful place. I probably would have killed myself with my recklessness had it not been for the harm reduction posts from this site!
Thanks!
Lemme just give quick background;
I'm 20 years old, male, about 140-150
Started doin sub recreationally last year with little bumps probs 1/10th of a mg. Fell in love
I never got the ridiculous euphoria with other opiates, vik, fent, oxy etc. Which I never understood.
Well eventually I wasn't getting high anymore (not what i mean by loss of magic) and found myself addicted.
Stayed maintained on my doses of >1mg for like 9 months.
Tried detoxing probs 4 or 5 times and everytime ended up going back and getting high. (succesfully i may add!!)
My most recent detox attempt was succesful, in terms of acute withdrawals. I was 12 days clean and for the most part (except for day 5) Ive been dealing with PAWS quite well. On to my question...
Ok, on day twelve off sub I decided I could probs reward myself by getting high once and flush the rest of the strip/film. Well I did probs half a mg (dissolved into water in a spoon and "snorted") well I began to feel the warm rush and talkativeness but then I got crazy sick, puking all night a total of probs 30+ trips to the toilet (most just dry heaves). You may say "well, obv. you did too much" which would make sense but even when I would do too much before I would get completely anihilated(sp?) and maybe one or two pukes and i was fine. Next night me and my girlfriend scored some killer molly, and molly will not work in w/ds or paws, for me at least. So I (blinded by the theory that I did too much the day before) did THE TINIEST little piece of strip, honestly no way to express it in mgs, and I got just as sick (although snortin the molly helped tremendously lol)
In summary (and I apologize for rambling, and for spelling/grammer errors as I am on an iPod)
My question is, did my body, given the multiple detoxes, reject the suboxone? And sort of punish me?
Or,
Is something else to blame? Possibly naloxone? Doesnt seem likely to me..
I thank all for reading through and appreciate all replies.
Also bluelight is such a wonderful place. I probably would have killed myself with my recklessness had it not been for the harm reduction posts from this site!
Thanks!
BlueberryfishY
Bluelighter
quick question, i've been getting the 8mg suboxone films from the same CVS for about 5 months now, the first few months everything was ok then when i got my script for the 4th time i noticed they we're very old (they would crack if i bent them and sometimes they would be broken when i opened them) and im wondering if the old batch would be less effective?
it seems like i almost have to double my dose to feel the same as if they were fresh ones.
it seems like i almost have to double my dose to feel the same as if they were fresh ones.
bupe is very strange indeed. I just got back on it for a few days and noticed something strange -- when I first started using it to get off norcos and oxys, I thought it was the jesus drug. I could take a little bit in the morning and just go about my day. i would drink, party, etc
now the other day I went back on it after a couple months of taking full agonists and I noticed that even after about 8-12 hours of taking only ~1mg, if I had ONE cocktail I would start to feel super fucked up. this has deterred me from wanting to drink unless I wait about 36 hours after dosing, even with doses as little as 1 mg. I am very lucky with opiate withdrawals, I can build up a large oxy/hydro habit and be pretty much all good (physically) after like 3-4 days of 1mg sub. my doc said not to drink on it...he said there werent any "real health risks" but also said that drinking could impair ability to drive, be sedating, etc. he said if too much sub and alcohol was consumed, it could potentially cause someone to stop breathing.
its my belief that sub is overprescribed and that most people would be fine with taking 2-4 mg/day and I cant understand how so many people are on 8-16 mg/day. it just seems unnecessary.
I just wanted to contribute some random facts/experiences to the thread since I am new to posting.
now the other day I went back on it after a couple months of taking full agonists and I noticed that even after about 8-12 hours of taking only ~1mg, if I had ONE cocktail I would start to feel super fucked up. this has deterred me from wanting to drink unless I wait about 36 hours after dosing, even with doses as little as 1 mg. I am very lucky with opiate withdrawals, I can build up a large oxy/hydro habit and be pretty much all good (physically) after like 3-4 days of 1mg sub. my doc said not to drink on it...he said there werent any "real health risks" but also said that drinking could impair ability to drive, be sedating, etc. he said if too much sub and alcohol was consumed, it could potentially cause someone to stop breathing.
its my belief that sub is overprescribed and that most people would be fine with taking 2-4 mg/day and I cant understand how so many people are on 8-16 mg/day. it just seems unnecessary.
I just wanted to contribute some random facts/experiences to the thread since I am new to posting.
Sobobuser89
Greenlighter
I hear you uno about sub and alcohol it always seemed to me that I could catch a nice buzz, but couldnt get "drunk" without getting to "my puking limit" first.
Not that I didnt try a million times, always ending with a nasty, puke filled night..
I think I remember reading somewhere about suboxone and alcohol (could have been someones opinion on a forum, so dont quote me) reacting negatively when in combination in the liver.
Not that I didnt try a million times, always ending with a nasty, puke filled night..
I think I remember reading somewhere about suboxone and alcohol (could have been someones opinion on a forum, so dont quote me) reacting negatively when in combination in the liver.
OK I have read so much in the Sub film thread and this one here but I have to ask it anyway. Been doing Suboxones for over a week now. Yesterday at 3pm I iv'd .2 of black tar Heroin-thats it. Not that strong either.I dont feel withdrawal coming on yet today but I know the body needs to be in withdrawal in order to take suboxone. My question: will I still get pwd's if I do not wait until I am in bad withdrawal? With the little I did am I starting the clock all over again? Or could I go ahead and take some now? Im staring at an 8mg pill here and im waiting for a response before I do anything. Thanks for responding!
HdoubleODeezy
Bluelighter
8mg is a huge dose if you are only taking around .2 of dope for your tolerance or even .3 (since you said you only felt .2 a little bit).. i bet you could get by on 1mg/day or deffinately 2mg/day.. low doses with bupe are the way to go. Less side effects and it feels better. and if it does cause pcwds it wouldn't feel as bad. Start low @ like .5mg and slowly work up until you are comfortable. I think u will feel relief before 8mg. I was on it for 4 years and started at 16mg/day and then worked down to .5-1mg in a matter of a month and stayed there until i quit.
Just my 2 cents. Goodluck %)
Just my 2 cents. Goodluck %)
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