Bupe Suboxone/Buprenorphine FAQ & Megathread v2; 2010

[astroboy007]

My buddy always said its better to be safe than sorry and take 1/4 of what you are used to, so if I was on 2 bags a day, to take 1/2 a bag in a needle. Even that seems high, because later on he recommended taking 1/4 a bag for the same habit.

Personally, I think you'll regret injecting it! The high isn't that good IME and I'd rather drink poppy tea.

So i have some saying not to have too much or it could really fuck me up and otherts saying they would rather drink poppy tea?

 

[cj]

You need to get under 2 mg shit I am in the process of tapering but I didnt get withdrawl until I got under 1 mg. Personally my plan is to switch to hydrocodone use it for around 2 weeks then make the jump from there liberally applying xanax and other benzos when im withdrawing. But jumping off at 4mg will be rough I recomend tapering further even if it takes a few months.

 

[Cane2theLeft]

----->Suboxone mega thread.


Please read through the resources at the start of this thread and in the 10 versions of this thread, this topic has been discussed a lot so there is TONS of information here.

 

[Suboxone]

Guys I want to get off suboxone. I have been on it for 6 months. Nobody tells you about how awful the withdrawals are going to be. I dropped down from 4mgs to 2mgs and had MAJOR anxiety issues. (Already have issues with anxiety and depression and the additional anxiety and depression was just too much to bear) SO my doctor took me back up to 4mgs of suboxone. I have been calling facilities to see if I can do inpatient detox off this shit. This stuff seems like the miracle drug but then once you have to come off it its worse than being on any other opiate.

Can anyone tell me what I'm in for if I go inpatient and take the plunge at 3-4mgs. How long it will take, what symptoms I will have etc... I know being in a hospital they try and make u feel somewhat better but my guess is they don't get rid of everything.

I had near no withdrawal symptoms jumping off at 2mg, using only a few key meds to help me get off. Just like with full agonist opiate withdrawal, most of the issues you're having are more than likely in your head. Just get some meds from your doctor, I used Compazine and Lyrica every day as well as OTC pain relievers. Everyone's symptoms vary, but it shouldn't be THAT bad.

Well this is very interesing, being on 16mgs a day sublingually, what would yopu recommend that i shoot, 8mgs?

If you're shooting more than 1-2mg and it's not helping, you need to taper down lower. The general consensus seems to be that it's useless to IV anything higher than that.

 

[barry351]

Raw smack, I dont agree with that, people get very confused by the two pills soboxone and plain buprenorphine. I have been on both and I do like the plain bups better, but as for taking the plain bups the one without the naloxone soon after using another true agonist (real opiate) heroin, morphine,ect.. you will still go into withdrawal.

The plain generic subutex (buprenorphine) will cause one to go into opiate withdrawal if its taken to soon, people think oh there is no blocker in plain bups, well its the buprenorphine that is the blocker, buprenorphine has a much stronger affinity for your brain receptors than all the other true 100% opiates, thats why bups are called a partial opiate, much of the europhia has been taken out of the buprenorphine. when one takes plain buprenorphine and has a true opiate agonist in thier system the bup kicks out all the opiates from the brain and withdrawal sets in rapidly.

I have taken soboxone to early and went into severe withdrawal, I have taken the plain buprenorphine to early and got the very same thing severe withdrawal. when you put the soboxone in your mouth the buprenorphine is absorbed and the blocker (naloxone) is passed out, the only time that naloxone gets in you is if you try to inject the soboxone, then the naloxone goes to work, thats why they put it in soboxone so you cant inject it. I have injected my subutex but its a pain is the ass, you really cant use a regular insulin syringe and I wont go into how I did it, but I now just take them as prescribed its not worth my time injecting them.

 

[JamtasticX]

Raw smack, I dont agree with that, people get very confused by the two pills soboxone and plain buprenorphine. I have been on both and I do like the plain bups better, but as for taking the plain bups the one without the naloxone soon after using another true agonist (real opiate) heroin, morphine,ect.. you will still go into withdrawal.

The plain generic subutex (buprenorphine) will cause one to go into opiate withdrawal if its taken to soon, people think oh there is no blocker in plain bups, well its the buprenorphine that is the blocker, buprenorphine has a much stronger affinity for your brain receptors than all the other true 100% opiates, thats why bups are called a partial opiate, much of the europhia has been taken out of the buprenorphine. when one takes plain buprenorphine and has a true opiate agonist in thier system the bup kicks out all the opiates from the brain and withdrawal sets in rapidly.

I have taken soboxone to early and went into severe withdrawal, I have taken the plain buprenorphine to early and got the very same thing severe withdrawal. when you put the soboxone in your mouth the buprenorphine is absorbed and the blocker (naloxone) is passed out, the only time that naloxone gets in you is if you try to inject the soboxone, then the naloxone goes to work, thats why they put it in soboxone so you cant inject it. I have injected my subutex but its a pain is the ass, you really cant use a regular insulin syringe and I wont go into how I did it, but I now just take them as prescribed its not worth my time injecting them.

Eh, you were going in the right direction, then you messed up. Buprenorphine has a higher affinity than naloxone, so even if they are injected the naloxone will still not bind. Therefore it is 100% POINTLESS.

 

[*=Regulator=*]

Now, please indulge a little theory I have...

As many of you will know, after a number of years of heavy weed smoking, some people inexplicably reach a point where smoking starts to bring on intense anxiety. I definitely went through that phase and stopped smoking weed altogether for a few years (incidentally when I first started taking opiates).

In the last six-eight months, I started smoking again and found that the anxiety had lessened and I could smoke comfortably. Could it be that the Suboxone was chilling me out enough that I was able to smoke weed without negative effects but now I'm no longer on Suboxone, the old weed anxiety is back? Could this actually be causing some of the insomnia? The weed has helped with nausea but I'm not sure if it's making me anxious (as I'd be blaming those effects on the Sub withdrawal). Does this make any sense at all or am I talking shit?

Can anyone weigh in on this theory for me? Just interested in opinions...

 

[barry351]

I would like to say one more thing about soboxone,subutex,buprenorphine ect.. this drug has whats called a ceiling affect, your brain can only absorb so much of it and then no more! I know this goes against common sense, usually you take more pills you get higher, well not so with the buprenorphine, I have tried it, I took one pill and an hour later took 4 at once just to see what would happen.

You know what happened ? I wasted some money, nothing more happened I got no higher, I now wonder if an addict can even overdose on this drug. Ya I know you can take to much of another opiate while on buprenorphine and overdose but it takes quite a bit.

So anyone thinking about taking more than two 16 milligrams at once and getting high I say save your pills its just a pure waste, I think this is a big reason doctors can prescribe buprenorphine, hey its really hard to abuse it, well if you are very clean, have no tolerance then you will get fucked up by taking even 4 mills, I was clean 2 years and took 8 mills, I was over the toilet all day. It was to much, I was amazed at how strong this stuff was to a person with no tolerance.

 

[Captain.Heroin]

Raw smack, I dont agree with that, people get very confused by the two pills soboxone and plain buprenorphine. I have been on both and I do like the plain bups better, but as for taking the plain bups the one without the naloxone soon after using another true agonist (real opiate) heroin, morphine,ect.. you will still go into withdrawal.

The plain generic subutex (buprenorphine) will cause one to go into opiate withdrawal if its taken to soon, people think oh there is no blocker in plain bups, well its the buprenorphine that is the blocker, buprenorphine has a much stronger affinity for your brain receptors than all the other true 100% opiates, thats why bups are called a partial opiate, much of the europhia has been taken out of the buprenorphine. when one takes plain buprenorphine and has a true opiate agonist in thier system the bup kicks out all the opiates from the brain and withdrawal sets in rapidly.

I have taken soboxone to early and went into severe withdrawal, I have taken the plain buprenorphine to early and got the very same thing severe withdrawal. when you put the soboxone in your mouth the buprenorphine is absorbed and the blocker (naloxone) is passed out, the only time that naloxone gets in you is if you try to inject the soboxone, then the naloxone goes to work, thats why they put it in soboxone so you cant inject it. I have injected my subutex but its a pain is the ass, you really cant use a regular insulin syringe and I wont go into how I did it, but I now just take them as prescribed its not worth my time injecting them.

You are actually incorrect; naloxone within Suboxone is inactive, even if you IV it. Suboxone can still be IV'd; I discuss this in the Frequently Asked Questions section of this thread, which is on the first page.

Can anyone weigh in on this theory for me? Just interested in opinions...

Even when I smoked heavily (at least 1/4 to 1/2 oz. of quality weed per day) I never got more anxiety than I had already previously had in life, so I can't really comment on your theory.

 

[barry351]

JamtasticX yes I agree on that I did not know that bups had a higher affinity that does naloxone, I should have figured that out because a few years ago I was dope sick and injected one 8 mill soboxone and it did help.

Maybe not as much as what Im on now plain bup but it did help so that would confirm your statement. thanks.

 

[Alcohol120]

okay so i'm trying to shoot some 8mg suboxone. i mean i know its not going to be comparable to like, dilaudid, which was my prev. DOC, but as far as i can tell this is so pointless. it seems so pointless infact that i think i might be doing something wrong.

my tolerance is not that high, i would do 30mg's of methadone IV and feel really great for a few hours. i could easily feel only 10mg's IV as well, so doing 1 8mg sub should do more than just feeling almost nothing right?

procedure;

crush pill in around 2cc's water, let it sit for about 1 minute and then micron filter and bang. i know i didnt miss, cuz i can taste a little orange after doing it, but i feel like, hardly anything.

someone let me know "/

 

[SkagKush]

^ 4mg would be horrible if you had no tolerance.....you would get so sick......

.5mg or less for a first timer.....

and .5mg to 2mg is perfect for people on maintenance to get some euphoria....keeping in mind you need to be at this dose for awhile.......

 

[Alcohol120]

im feeling absolutely nothing from this... what am i doing wrong?

 

[SkagKush]

^ your doing way way way to much man......

next time try like .5mg to 1mg.....

 

[barry351]

Captain you said the naloxone in soboxone is inactive even if you I-V it ? hmm I just googled that.

The naloxone in soboxone is not orally absorbed so if the soboxone was taken orally the naloxone will have little or no effect on the action of other drugs.If
the suboxone is crushed and injected,the naloxone will block the effect of drugs with opiate receptor agonism for several hours(it has a half life of 64 mins). This is in fact why naloxone is included in suboxone,to prevent misuse by injection. It is important to remember,however,that the other drug in suboxone,buprenorphine, has a very high affinity for opiate receptors and itself will block the action of most other opiates. Buprenorphine has a half life of 20 to 44 hours.

Ya I know you cant believe everything you read on the net, this was just one of the sites I checked, but the way they are saying this I would think the naloxone does indeed work if it is injected, for instance the other name for naloxone is narcan, this is given for most if not all opiate overdose, I have seen it in action and Im glad I have never needed it.

 

[JamtasticX]

Captain you said the naloxone in soboxone is inactive even if you I-V it ? hmm I just googled that.

The naloxone in soboxone is not orally absorbed so if the soboxone was taken orally the naloxone will have little or no effect on the action of other drugs.If
the suboxone is crushed and injected,the naloxone will block the effect of drugs with opiate receptor agonism for several hours(it has a half life of 64 mins). This is in fact why naloxone is included in suboxone,to prevent misuse by injection. It is important to remember,however,that the other drug in suboxone,buprenorphine, has a very high affinity for opiate receptors and itself will block the action of most other opiates. Buprenorphine has a half life of 20 to 44 hours.

Ya I know you cant believe everything you read on the net, this was just one of the sites I checked, but the way they are saying this I would think the naloxone does indeed work if it is injected, for instance the other name for naloxone is narcan, this is given for most if not all opiate overdose, I have seen it in action and Im glad I have never needed it.

Here's the problem with that argument. Both naloxone and bupreorphine are opiates/opiods (whatever). The only difference is one is an agonist/antagonist, and the other is a straight antagonist.

It is true that naloxone is the drug in narcan that is used for opiate overdoses, however, if someone were to overdose on bupreorphine narcan would not help them.

Buprenorphoine has a higher affinity than naloxone, so it will block the naloxone. The only time naloxone would come into effect is if youhad say 10 receptors, and 5 of them filled with bupe the other 5 would fill with naloxone. Then if you did some heroin , the naloxone would block it while it's there. However, that is the only instance in which naloxone will bind. So if you took the 5 receptors of bupe under the tongue, the 5 of naloxone would not bind, and you could do 5 receptors worth of heroin right away instead of waiting for the naloxone to disappear.

 

[*=Regulator=*]

The naloxone in Suboxone will not do anything at all irrespective of whether you snort it, put it under your tounge, stick it up your ass or shoot it intraveneously. It is a total myth perpetuated by the manufacturers of the drug.

Google away and you'll find page after page saying that the naloxone will put you into withdrawal if you shoot it but it's all 100% bullshit. Many, many people on this site have first hand experience and can vouch for the fact that the naloxone does NOTHING.

 

[barry351]

As for europhia from buprenorphine, not much, I have done it when clean I mean years clean. I did 8 milligrams and I got real sick, I couldnt move without puking, I did get the itching and I was on the nod but it was just not that good.
Anyone that has a tolerance to opiates I say good luck on the europhia, I was 48 hours sick one time and I injected one of my 8 mill subutex(buprenorphine) and it did get me well instantly but as for europhia hmmm not much.

 

[Captain.Heroin]

okay so i'm trying to shoot some 8mg suboxone. i mean i know its not going to be comparable to like, dilaudid, which was my prev. DOC, but as far as i can tell this is so pointless. it seems so pointless infact that i think i might be doing something wrong.

my tolerance is not that high, i would do 30mg's of methadone IV and feel really great for a few hours. i could easily feel only 10mg's IV as well, so doing 1 8mg sub should do more than just feeling almost nothing right?

procedure;

crush pill in around 2cc's water, let it sit for about 1 minute and then micron filter and bang. i know i didnt miss, cuz i can taste a little orange after doing it, but i feel like, hardly anything.

someone let me know "/

You want to try 0.5mg, or 1mg, but definitely not 8mg at a time.

Captain you said the naloxone in soboxone is inactive even if you I-V it ? hmm I just googled that.

Understanding receptor affinity, and pharmacology, is much more difficult and advanced than merely understanding how to build a website.

Regulator's notion of a "naloxone myth" is correct; there is no factual or scientific basis behind why Suboxone contains naloxone. The only reason it is in there, is due to DEA drug scheduling, so that Suboxone could be CIII and seen as containing another "active" ingredient to prevent "abuse/misuse", whereas Subutex would be CII.

Schedule II,
n a category of drugs considered to have a strong potential for abuse or addiction but that also have legitimate medical use. Included are opium, morphine, and cocaine.
Schedule III,
n a category of drugs that have less potential for abuse or addiction than Schedule I or II drugs and have a useful medical purpose. Included are short-acting barbiturates and amphetamines.

http://medical-dictionary.thefreedictionary.com/Schedule+I+drug

 

[barry351]

For more info on buprenorphine overdose google( Buprenorphine: toxicity and overdose:emergency medicine news).
some of it talks about children that have overdosed on buprenorphine,children in the 2 year old range, they were taken to hospital and it took large amounts of naloxone but it says it did work.
Personally I doubt I could overdose on buprenorphine, 5 did nothing more than one did, if they were not so expensive I would give it a go right now.

Im taken my seraquel and passing out good night everone, great argument!