ruffneck81
Greenlighter
- Joined
- Aug 8, 2008
- Messages
- 43
keep in mind that i do not swallow the suboxone after it has disolved.
some people metabolize drugs faster. The average half life of suboxone is 37 hours, from 20-70. I was also able to get high 24 hours after a 4mg dose. 4mg is a low dose, any higher and u probably wouldn't be be able to get high.
Lets say you take 8mg Suboxone in the morning and then Later that night you take 80mg Oxycontin, then the next morning you pop another 8mg Suboxone... would you be sent into Precipitated W/D then?? If not, why? That always confused me and I haven't seen it discussed on here...
Yea I'm sure someone HAS answered this question but I can't seem to find it so please Captain.Heroin or someone else who sounds smart answer this one:
So I know that if you were to take say 80mg Oxycontin and 2 hours later pop a 8mg Suboxone you would be sent in to Precipitated W/D... BUT, what I don't understand its if you pop 8mg of Suboxone and THEN 2 hours later take 8mg Suboxone you would be fine.... NOW to the question:
Lets say you take 8mg Suboxone in the morning and then Later that night you take 80mg Oxycontin, then the next morning you pop another 8mg Suboxone... would you be sent into Precipitated W/D then?? If not, why? That always confused me and I haven't seen it discussed on here...
edit: I think I asked that right but I must admit it sounded a lot better in my head...
also if you DON'T swallow the bupe/saliva after totally disolved wouldn't that take out the naloxone?
Many things cause a migrane.^^^^I usually spit out the sub after its done dissolving to make sure i dont swallow the nalaxone...Not even sure if it makes a difference... but lately ive been getting massive migraines from sub... its also pointless to swallow so might as well spit it out
Incorrect.Because bupe rips out the receptors and only partially fills some of them (mostly the Mu receptor)...
http://en.wikipedia.org/wiki/Buprenorphine said:Buprenorphine is a thebaine derivative with powerful analgesia approximately twenty-five to forty times as potent as morphine,[11] and its analgesic effect is due to partial agonist activity at μ-opioid receptors, i.e., when the molecule binds to a receptor, it is less likely to transduce a response in contrast to a full agonist such as morphine. Buprenorphine also has very high binding affinity for the μ receptor such that opioid receptor antagonists (e.g. naloxone) only partially reverse its effects. These two properties must be carefully considered by the practitioner, as an overdose cannot be easily reversed (although overdose is unlikely in addicted patients or people with tolerance to opioids who use the drug sublingually as meant in the case of Subutex/Suboxone, especially if there are no benzodiazepines involved), and use in persons physically dependent on full-agonist opioids may trigger opioid withdrawal that also cannot be easily reversed and can last over twenty-four hours, as the drug's mean half-life is thirty-seven hours.
Buprenorphine is also a κ-opioid receptor antagonist, and partial/full agonist at the recombinant human ORL1 nociceptin receptor.[12]
Buprenorphine hydrochloride is administered by intramuscular injection, intravenous infusion, via a transdermal patch, as a sublingual tablet or an ethanolic liquid oral solution. It is not administered orally, due to very high first-pass metabolism. Buprenorphine is metabolised by the liver, via the CYP3A4 isozyme of the cytochrome P450 enzyme system, into norbuprenorphine (by N-dealkylation), glucuronidation and other metabolites. The metabolites are further conjugated with glucuronic acid and eliminated mainly through excretion into the bile. The elimination half-life of buprenorphine is 20–73 hours (mean 37). Due to the mainly hepatic elimination there is no risk of accumulation in patients with renal impairment and in the elderly.
The main active metabolite, norbuprenorphine, is a δ-opioid receptor and ORL1 receptor agonist and a μ- and κ-opioid receptor partial agonist. However, buprenorphine antagonizes its effects at the k-opiod receptor.
The doc said that if this doesn't work, he will talk to my pharmacy - and se if they would be OK with taking my blood pressure. I get on with them very well, and see them every day so I can't see it being too much of an issue. They have often said that they can see I'm making a real effort with this..