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Bupe Suboxone/Buprenorphine FAQ and Megathread v.1; 2007 - 2010

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formanchristopher said:
Thanks for the guidance. Is there a "tutorial" on using the quote buttons?
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Well, you can copy the text and then click the quote button in the quick reply section towards the bottom of the page and post it in there. It looks like you are using the quote button under the posts, and then deleting the end quote tag?
 
About the Nalaxone...it's been being used to deter alcoholism for years, and really is in the literature. It was my Suboxone doc who enlightened me on this, and he's more than a doctor, he's an Addictionoligist (big word for a doctor who goes back to school to study further about addiction, and/or addictive meds), and out of the 3 in my smaller town? All 3 are really "pro"
opiate replacement therepy kind of doctors. The difference is like talking to a person who's actually used or been strung out, rather than a regular doc who's always looking for the signs that one is drug-seeking, and is usually not as understanding/accepting of an addict.
 
yo bot, i've never gotten precipitated withdrawals before fortunately. i've even dosed my suboxone only 14-17 hours after last shot and never had any problems besides maybe panic attacks from worrying if i actually was gonna go into precip w/d. thats why i don't do the switch from full agonist to sub anymore, cause i hate waiting to get back on suboxone and worrying about precip w/d. fuck that.


formanchristopher, yes i know naloxone/naltrexone is commonly used in treating alcoholics but it is usually the naltexone by itself that they use for alcoholics. but that still doesn't change the fact that in suboxone, the mixture of buprenorphine & naloxone, the bupe overpowers the naloxone everytime, and that makes the naloxone inactive basically, so the naloxone in suboxone tablets is not doing anything. if you were just taking naltrexone/naloxone by itself and no bupe, then yes it would work.
surprisingly though, most doctors either don't know that the naloxone is overpowered by bupe or just don't tell ppl cause they want ppl to think they will go into precipitated withdrawal if they abuse suboxone. it also doesn't matter what ROA you use with suboxone, the bupe always overpowers the naloxone, even if you inject suboxone.
 
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^ It should look like this (I'll put spaces in between every character of the quote code so it doesn't read it):

[ Q U O T E = M r B l o n d e]Testing one two three, drop 400, testing one two three, drop 1.2[ / Q U O T E ]
 
Kay....well little over 24 hours has passed...and I took the COWS test to find that I'm scoring around a 7...so I just cautiously took about 2 mgs of sub.

How soon's precipitated withdrawal supposed to hit you?

It's been 10 minutes give or take, and I feel fine. Slightly better I'd say. Ima give it a while longer than take another 2 mg.

2 more mgs and still feeling good. Still cold, but not shaky, not yawny, no runny nose/eyes, I guess I do feel better.

2 more still.... Should I keep dosing until I feel like my old self again?

Kay, my dose is up to 8mg, and I just woke up from a little nap feeling quite nearly like a million bucks. Well, maybe more like 800,000, but definitely better, and not floored by any sudden withdrawal, so I think I'm all set :\ Sure beats the hell out of cold turkey....holy shit, does that suck!

I've got 6 more 8mg pills, any advice on how to wean myself off them? I could probably get more if need be, but I don't have a script, so it's up to shady dealing with some junkie friends, and I wanna take a little break (or a long fucken break) from this stuff, and seeing those kids again is going to be seriously tempting.

I was thinking I'd do 3 days at 8 mg, 3 days or so at 4 mg, then use the rest in 2 mg doses. Does that sound reasonable? Any advice?

It's quick and dirty, and I was sniffin about a jersey bundle daily for a month and half a bundle daily for a month before that, and the month prior to that I was working up my tolerance with little tastes here and there. It's my fourth or so time coming clean in the past 3 years, but first time not going cold turkey. Subox I can already tell is a world of relief. It fucking turned my day right around, that's for sure.

take care guyz n gals :D
 
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Mr Blonde said:

Smoking cannabis 'increases the risk of aggressive testicular cancer'.
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I find that hard to believe.

Would you count a fatal car accident by someone under the influence of marijuana as a related death?
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You can't test for such a thing, and I've never heard of crashing their car because of marijuana. Benzos or alcohol or heroin, maybe, nitrous yes...but weed? I don't think so.

Not trying to be antagonistic here, but smoking any kind of plant material regularly is likely to be carcinogenic.
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For tobacco, sure.

Many people preach that marijuana kills no one, I don't see why you're vehemently trying to prove that it might.
 
Crashing a car from weed? I'm a aggressive driver when I'm sober, I speed, drift on crazy hairpins, race, etc with no passengers. Never had a ticket in my 5 years of driving, neither have I scratched my vehicle. and I learned to drive in NYC and Manhattan, I like to think of it as fun, you really gotta pay attention and know how to weave.

When I smoke weed, I see that bright red stop sign 20 feet away and slowly crawl up to it.
 
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Bubbble, I wasn't aware you only had that many. The longer you went before getting on sub, the less length of time you'd have to stay on it.

Now getting off sub isn't going to be a breeze either, in fact w/d's although not as severe will be more drawn out. If you want to get off with no symptoms, you may have to taper your dose to 0.5mg or less.

You have 48mg. I don't believe you need to continue to take 8mg to feel better. Now if you snort it, bioavailability goes up to 50% and if you plug it you get even more, about 65%. The way it is prescribed, you absorb only 30-40%.

I would do a schedule as such.

Take 4mg for tomorrow's dose.
48 hours later, or if you are withdrawing, take 4mg.
36 hours later, take 3mg.
36 hours later, take 3mg
24 hours later take 2mg.
24 hours later, 2mg.
24 hours later, 2mg.
36 hours later, 2mg.
48 hours, later 2mg.
(By this point the buprenorphine will have attached itself to proteins in your bloodstream to create a protein drug complex that will slowly release small amounts into your bloodstream that is active. 96% of the drug binds to the proteins, and is inactive as such)
48 hours later, take 1mg in the morning, 1mg at night.
Repeat for 4 days.
Drop down to 0.5mg twice a day, for 3 days
Skip a day, then take 0.5mg twice that day.
The following day
Then take 0.5mg once a day for 7 days
Then 0.5mg every other day.
Then clean.

It may be uncomfortable at times, but this would minimize the greatest degree of discomfort. Suboxone initially requires a larger initiation dose, as you repeat it, you won't need as much and the effects will last longer. If you're not sick when its time to take your next dose, that means you have reserves of sub in your bloodstream, it will also make the transition to smaller doses easier.
 
It's not the worst thing to snort, it doesn't burn. The taste sucks, but its no worse than sublingual taste. I used to sniff a whole 8mg straight up. *gag* Plus the guy only has a few, I'd make sure I get the very most out of every milligram if I was him.
 
^not physically addicting?? i highly doubt that. suboxone has nearly as bad of w/ds as other strong opioids, except it has a milder overall w/d but lasts alot longer. also, buprenorphine is a partial agonist so it has some activity at the mu opioid receptors.
 
chrisinabox said:
^not physically addicting?? i highly doubt that. suboxone has nearly as bad of w/ds as other strong opioids, except it has a milder overall w/d but lasts alot longer. also, buprenorphine is a partial agonist so it has some activity at the mu opioid receptors.
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Buprenorphine has agonist effects at delta and kappa receptors, if I'm not mistaken, and not mu opioid receptors.

Mu-opioid agonists include hydrocodone, oxycodone, morphine, etc.

Buprenorphine is not in that ball park; this is why you must wait in between taking buprenorphine and the others, and vice versa.

If I'm wrong, someone can tell me what buprenorphine binds to, but I'm pretty sure it's not the mu-agonists. I don't do mu-agonists; methadone is a mu-agonist.

Suboxone is not one.

Suboxone is not physically addicting in the same sense that morphine is.
 
Captain.Heroin said:
Buprenorphine has agonist effects at delta and kappa receptors, if I'm not mistaken, and not mu opioid receptors.

Mu-opioid agonists include hydrocodone, oxycodone, morphine, etc.

Buprenorphine is not in that ball park; this is why you must wait in between taking buprenorphine and the others, and vice versa.

If I'm wrong, someone can tell me what buprenorphine binds to, but I'm pretty sure it's not the mu-agonists. I don't do mu-agonists; methadone is a mu-agonist.

Suboxone is not one.

Suboxone is not physically addicting in the same sense that morphine is.
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Buprenorphine is a thebaine derivative with powerful analgesia approximately twenty-five to forty times as potent as morphine,[11] and its analgesic effect is due to partial agonist activity at μ-opioid receptors, i.e., when the molecule binds to a receptor, it is less likely to transduce a response in contrast to a full agonist such as morphine.

Buprenorphine is also a κ-opioid receptor antagonist, and partial/full agonist at the recombinant human ORL1 nociceptin receptor.[12]


buprenorphine does have agonist effects at the mu opioid receptors, its just a partial agonist instead of full agonist.

the reason you have to wait between taking bupe and other opioids is because bupe has a very high affinity for the receptors and it overpowers other opioids for the receptors. if bupe did not have agonistic effects at the mu opioid receptors, then how would it block the effects of things like morphine and hydrocodone and oxycodone, regular full agonists?? thats why if you on bupe and you try to get high on something like say heroin, you have to do a big amount, IF you can even get high at all. also, when your waiting you get on bupe, you have to wait a certain amount of time b/c if you take the bupe too soon, it will rip whatever remaining opioids that are on your receptors off, causing precipitated withdrawal.

also, bupe does have a withdrawal like other opioids but it has a very long half-life causing the withdrawal to be mild but very long. lots of ppl have a very hard time coming off of buprenorphine. personally, i don't think its quite as bad as something like say heroin w/ds but its definitely not easy at all.
 
I would do a schedule as such.

Take 4mg for tomorrow's dose.
48 hours later, or if you are withdrawing, take 4mg.
36 hours later, take 3mg.
36 hours later, take 3mg
24 hours later take 2mg.
24 hours later, 2mg.
24 hours later, 2mg.
36 hours later, 2mg.
48 hours, later 2mg.
(By this point the buprenorphine will have attached itself to proteins in your bloodstream to create a protein drug complex that will slowly release small amounts into your bloodstream that is active. 96% of the drug binds to the proteins, and is inactive as such)
48 hours later, take 1mg in the morning, 1mg at night.
Repeat for 4 days.
Drop down to 0.5mg twice a day, for 3 days
Skip a day, then take 0.5mg twice that day.
The following day
Then take 0.5mg once a day for 7 days
Then 0.5mg every other day.
Then clean.
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This is awesome and perfect advice...Very much appreciated!

Thank you good sir! :D:D
 
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