In my experience Salvinorin in the pure crystalline or powdered form is very safe to handle. I have worked with pure salvinorin both dry and dissolved into various solvents and have never had the slightest effect when handling this compound or solvents containing large amounts of it. Salvinorin isn't easily absorbed through the skin, even when dissolved into Alcohol and held in the mouth salvinorin is poorly absorbed. I have tried using powdered crystalline salvinorin under my tongue from 5 milligrams working in small increments all the way up to 25 milligrams (which is 25 times the amount some individuals smoke) sublingually without Alcohol with absolutely no effect and when swallowed had no effect either. I have also tried up to 25 mg of the powder sublingually together with a few ml of 151 Proof Ethanol drinking Alcohol under my tongue with no effect. It appears that for salvinorin to be absorbed sublingually that it must be thoroughly dissolved into Alcohol or infused into something chewable so that you can thoroughly masticate the powder into extremely fine particles which are small enough to be absorbed, as reported by more than one individual but I have never tried it to know first hand, but I can report that just having pure crystalline salvinorin powder in your mouth with an amount of 151 Proof Ethanol didn't work for me at all. The only caution I can think of is when handling salvinorin is that if you are a smoker and have transferred salvinorin residues on your hands from an extraction onto a cigarette this could cause an unexpected journey, other than that pure salvinorin appears to be almost inert for effect unless absorbed through the use of a properly prepared tincture or smoked.
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