Strangest drugs.

[ShulginsReincarnation]

LSD at 2.5mg or Shrooms at 20 ~ 40g can do the same thing.

I have come to understand that LSD (at any dose) is a partial D2 agonist at about the 4 hour mark and beyond (as the substance begins to dissociate from the serotonin receptor sites I believe [though this timing regarding dissociation from the serotonin receptors correlating with the beginning of D2 agonism wasn't mentioned by the doctor I learned this from; just me thinking aloud here,]) but I have never heard of mushrooms doing this at any dose which I believe is why I have eaten 10+ grams at once before and all it did was cause me to essentially become paralyzed by the intensity of the experience for a couple hours until I began to come down. You state at 20-40 grams which is quite high, so I can't comment. However, something tells me mushrooms don't have quite the same effect on D2 as LSD considering even 200micrograms causes quite a pronounced stimulation in me whereas even the high dose mushrooms simply sedate me. I could be wrong about the mushrooms, so I would love to see the source of information you are citing here in your post so I can try to better understand the mechanism(s) by which this occurs.

 

[LucidSDreamr]

It a SNRI at high doses.

I’ve taken Multiple different SNRIs and never had any visuals whatsoever from them; especially psychedelic mushroom visuals from them. Vines climbing up the wall etc.

Maybe the shadow ppl are from the NRI activity but still doesn’t explain how no other NRIs seems to cause this

Does take tapentadol inhibit different NR subtypes than the SNRI antidepressants or is it less selective for subtypes?

Sometimes we don’t know everything about a drugs pharmacology and metabolic profile. I find it interesting that tapentadol is a homologou of a phenethyleamine or amphetamine and wonder if it’s fitting into a pocket somehow. I beleieve Shulgin showed that homologizing
the main ethylamine Chain by one extra carbon kill psychedelic 5HT R agonism activity….or does it?

Not outside the realm
Of possibility I think

I have gotten closed eye visials from pure mu agonists like dilaided, specially when IVed and going from 0to 100 instantly; But never long term sustained open eye visials and breathing and patterning on objects like with tapentadoll.

 

[bigjackaal96]

I’ve taken Multiple different SNRIs and never had any visuals whatsoever from them; especially psychedelic mushroom visuals from them. Vines climbing up the wall etc.

Maybe the shadow ppl are from the NRI activity but still doesn’t explain how no other NRIs seems to cause this

Does take tapentadol inhibit different NR subtypes than the SNRI antidepressants or is it less selective for subtypes?

Sometimes we don’t know everything about a drugs pharmacology and metabolic profile. I find it interesting that tapentadol is a homologou of a phenethyleamine or amphetamine and wonder if it’s fitting into a pocket somehow. I beleieve Shulgin showed that homologizing
the main ethylamine Chain by one extra carbon kill psychedelic 5HT R agonism activity….or does it?

Not outside the realm
Of possibility I think

I have gotten closed eye visials from pure mu agonists like dilaided, specially when IVed and going from 0to 100 instantly; But never long term sustained open eye visials and breathing and patterning on objects like with tapentadoll.

Most SNRI's need very high dose to get 90 ~ 100% inhibtion on SERT, DXM get's there at 300 ~ 650mg. Norepinephrine Is the main reason why DPH/Benadryl Is so rough at 50 ~ 1200mg, Maybe Mu agonism Is masking the dysphoric nature allowing much higher doses?.