Strange Adderall XR - Adderall IR amphetamine interaction/tolerance issue

[Soap MacTavish]

I got switched to Adderall XR recently and although I don't get hammered from it I do appreciate the long-lasting effect to help me concentrating and not shaking so much. I'll probably be sticking with these.

Here's my question: I also had a bunch of Adderall IR 30mg tabs left when I switched so yesterday I took my XR in the morning and decided (although I wasn't coming down) to bump it up in the middle of the morning so I popped a 30mg IR tab. Nothing happened. I couldn't believe it so I popped another half (15mg). Nothing happened. I may have become a little more shaky, that's it.

This seems incredible to me since under any other normal day if I took 45mgs I would be pretty toasted, but this time nothing.

The same exact sequence presented itself the next day when I tried it again in the afternoon. It almost seemed like the XR was inhibiting or blocking the IR. Is this possible?

What else could be at work here?

Warm Regards,
Soap

 

[bronson]

That is very odd indeed. I don't believe the XR has any inhibiting property on the IR. Perhaps just an issue of increased tolerance over time is the only thing I can really think of. Maybe someone else will have a more scientific answer for this.

 

[Soap MacTavish]

seems that unfortunately I believe you are right. These XR's have skyrocketed my tolerance in a very short time.

 

[bbd]

Maybe it's something about how the XR releases....
The XR releases small doses throughout the day. Maybe, considering the short amt of time in between taking both, the IR 'attached' to the XR to be deposited later in the day? Someone I know takes 20 mg XR in the morning and then a 10 IR in the late afternoon, for homework and such, and she feels the IR just fine. Did you eat anything? I'm not confident on this answer, but maybe itll bring up more legitimate ideas from other peeps.

 

[Intenselife]

XR is good for therapeutic, it takes me a high dose of them to feel recreational, i like the IR's that i am prescribed but i don;t use more than twice a week or up my dosage so it works for me everytime, and followed by a god awful crash that i can counteract with my klonopin to an extent recently i found weed works good too

 

[DexyDevil]

It is actually much easier to become tolerant to amphetamines when taking XRs. This is because they stay in your system much longer.

However, there must be some other factor at play here, because you shouldn't be THAT tolerant. Personally, Adderall XR is crap for me. Sooooo unpredictable since the formula change. The effects are just all over the place and some days they work, some days they don't. Sometimes they work well in the morning but not the afternoon, and vice versa. The only more unpredictable XR amp is Vyvanse.