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Stimulants of the Future

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I don't.

It spurs me to study harder those resources that I have access to, and indulge in more and more of journal articles and my own experience of both stimulant and psychedelic psychoactives.


I consider desoxypipradrol fantastic as a stimulant, but I'm a bit weary about the tolerance and possible negative effects of that tolerance in the long run. Is there substances of the same subjective character, or any possibility to limit tolerance gaining from desoxypipradrol? I'd consider it an old stimulant of future importance if it can be handled safely.
 
I've never had the pleasure of trying desoxypipradol as I've never encountered it. It is very potent and quite long lasting. I think people really overdo it dosewise--considering that it is active at around 2mg, a good dose should be under 5mg, taken only in the early morning (like an ICBM under your ass). Obviously, people taking 10-20mg of it several times a day are going to have insane problems with insomnia.

If you want a desoxypipradrol analogue that is shorter-acting, try pipradrol itself. The hydroxyl group doesn't dramatically weaken the stimulant effect, but it does give the body an easy metabolic target for conjugation/elimination. But good luck finding pipradrol, it is even rarer than its desoxy brother.
 
The synthesis is pretty easy, the piperidine acid chloride + diphenyl grignard should work.
It's amazing it doesn't crop up more actually . (pipradrol)
 
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^ I think it is more likely to be indirectly made from chloromethyl pyridine plus the diphenyl ketone, benzophenone then reduction of the pyridine ring.
 
Thanatopium said:
4-MAR is long acting to say the least, and takes a heavy toll on the body IMHO. Plain old aminorex should be rated as far more euphorigenic than methamp or even cocaine. Body rushes, the works.
Click to expand...

I've tried 4MAR and I liked it a lot. I took 50mg in the morning (about 10am) and it seemed to wear off at about 10pm so that's 12 hours. It felt more entacogenic than amphetamines, it was like a low dose of MDMA with some methamphetamine but it had fewer physical effects.

How does 'plain' aminorex compare on dosage and duration? How much is it wise to take? I'm wondering about the sreies because, for example, the p-F analog is supposed to be almost 5 times more potent than the parent (1.2mg/kg as opposed to 5.8mg/Kg).

With (meth)amphetamines, the p-F analog is slightly less potent. I am beginning to think that the aminorex skeleton doesn't work like amphetamines. I suspect it might be a dopamine & norepinaphrine reuptake inhibitor...

I think with it's similar structure to amphetamines, people have assumed that it's action is similar. I am becomming more & more certain that it's not...
 
Ooh, cool. I'd like to try (R)-modafinil to see how it compares to the original. Intuition tells me that there would be almost no difference--the (R)-enantiomer as a drug is most likely just a patent-extending strategy by Cephalon in the wake of decent generic modafinil (I hope that is available soon).
 
Morpholino-Pipradrol

It was debated what effect the pipradrol analogue with a morpholine ring instead of the piperidine ring would have. Here is a patent describing this compound: US 2'947'749.
 
bk-2-benzylpiperidine and bk-2-piperonylpiperidine are two easy (1-step reaction) targets which have not, to my knowledge, been bioassayed as of yet. Also,
bk-3-benzylmorpholine and bk-3-piperonylmorpholine.

So many drugs, so few resources.
 
Holy_cow said:
It was debated what effect the pipradrol analogue with a morpholine ring instead of the piperidine ring would have. Here is a patent describing this compound: US 2'947'749.
Click to expand...

Most potent of the series (applies to both pipradrol & desoxypipradrol morpholine derivatives); think the DAT affinity was 50% greater for the morpholine compared with desoxypipradrol. What I've been wondering is if the morpholine derivative been the most potent heterocyclic wouls also work for drugs with a single aromatic group (eh methylphenidate)
 
Riemann Zeta said:
I've never had the pleasure of trying desoxypipradol as I've never encountered it. It is very potent and quite long lasting. I think people really overdo it dosewise--considering that it is active at around 2mg, a good dose should be under 5mg, taken only in the early morning (like an ICBM under your ass). Obviously, people taking 10-20mg of it several times a day are going to have insane problems with insomnia.

If you want a desoxypipradrol analogue that is shorter-acting, try pipradrol itself. The hydroxyl group doesn't dramatically weaken the stimulant effect, but it does give the body an easy metabolic target for conjugation/elimination. But good luck finding pipradrol, it is even rarer than its desoxy brother.
Click to expand...

In the country I'm currently residing, Sweden, it seems like the overdoing is quite abundant among those who like desoxypipradrol. Doses from 10 mg upwards are frequently reported in some of the larger drugrelated forums, as well as redoses as soon as a few hours from first dose.

I'm fond of the long-acting properties of desoxypipradrol, it's kind of nice to have a full 24hrs of an alert and waken state of mind, on two dosings, 2+4 mgs seven hours apart, with no negative aftereffects as far as I've noticed the six times I've done it. It seems like I need three to five weeks without stimulants of the same charater, DAT-inhibiting &c., for the tolerance to lower, but it's hard to determine whether it actually drops since the desoxypipradrol is so subtle.
 
fastandbulbous,
I'm quite sure that the morpholine analogue of methylphenidate (which I'm on right now) will be quite a bit stronger than the parent compound.

Have them whip us up a batch!
 
Anyone tried chasing desoxy like heroin? It has an effect right away & an actual rush... that lasts for 2-3 hours. I dunno about low doses, I've only ever taken 10mg+ at once...
 
Riemann Zeta said:
Ooh, cool. I'd like to try (R)-modafinil to see how it compares to the original. Intuition tells me that there would be almost no difference--the (R)-enantiomer as a drug is most likely just a patent-extending strategy by Cephalon in the wake of decent generic modafinil (I hope that is available soon).
Click to expand...

I currently use generic modafinil. The R form is more potent and abit cleaner of a stimulant. There is a noticeable difference but perhaps not as strong as the different between R-Lipoic acid and ALA.
 
I had came up with some new ideas for possible stimulants.

1-(4-methylthiophenyl)piperazine (I would call this MeSPP)

This is the sulfur analogue of MeOPP, where the methoxy group is replaced with a methylthio group. Given the increase in potency as you go from PMA to 4-MTA, it's possible that MeSPP would be slightly stronger than MeOPP. The only thing I can find regarding this analogue is listed here:

http://www.wipo.int/pctdb/en/wo.jsp?IA=WO2006094843&DISPLAY=DESC

The analogue is listed under "Description 40".

1-phenethylpiperazine

This one is similar to BZP in structure, but the benzyl group of BZP has been extended by an extra CH2. The benzyl group can be represented as C6H5CH2, while phenethyl can be represented as C6H5CH2CH2. It vaguely looks similar to phenethylamine, where a piperazine ring takes the place of the amino group.

Now for some possible non-piperazine based stimulants:

N-methyl-1-cyclopropyl-propan-2-amine
N-methyl-1-cyclobutyl-propan-2-amine

These two look similar to methamphetamine, except the phenyl ring has been replaced by a cyclopropyl and cyclobutyl ring respectively. Since Cyclopentamine (cyclopentyl analogue) and Propylhexedrine (cyclohexyl analogue) are stimulants, the cyclopropyl and cyclobutyl analogues may also be stimulants as well.
 
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I'm sure they'll have some stimulant activity, but I sure as hell wouldn't touch them. ick.

if propylhexedrine is migraine in a sniffer, I can't imagine what these would be like!
 
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