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Stimulants of the Future

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There have been whispers of late of 4-methyl-5-(3,4 methylenedioxyphenyl)-2-amino-oxazoline. I know the naming is wrong but I just can't be assed to figure it out. Picture 4-methylaminorex with the methylenedioxy group on the benzene ring. I'm assuming it'll be a stimulant.

Anyone have any info on this?

There has also been whispers of the trimethoxy analogue of this. Stimulant, psychedelic or chemical Parkinson's?
 
^One would guess it would be similar to MDMA, but one would not know without trying it.

Back on Topic:
phenyl 3-morpholinyl ether hcl.
 
Langevin said:
There have been whispers of late of 4-methyl-5-(3,4 methylenedioxyphenyl)-2-amino-oxazoline. I know the naming is wrong but I just can't be assed to figure it out. Picture 4-methylaminorex with the methylenedioxy group on the benzene ring. I'm assuming it'll be a stimulant.

Anyone have any info on this?

There has also been whispers of the trimethoxy analogue of this. Stimulant, psychedelic or chemical Parkinson's?
Click to expand...


Well para-fluoro 4-MAR was reported as being entactogenic by a friend, so that bodes well for the ring substituted methylenedioxy compound being interesting (comparing amphetamine & 4-mar). Never a guarantee though, sadly!
 
An important thing to remember is that dopamine's, or "DA," structure is called
3,4-dihydroxyphenethylamine, where "di" means 2, "hydroxy" means -OH radical, "phen" stands for a particular cyclic carbon (C) and hydrogen (H) ring having C6H6 as its empirical formula, "ethyl" stands for -CH2CH2-, and "amine" meaning -NH2 or ammonia ("smelling salt") radical. All connected in that order.

The root "dop" [long 'o'] means "very good."
Literally, "very good smelling salt."
Hope that helps someone.
 
fastandbulbous said:
^ Where was that, I can't remember seeing anything about 2-aminotetralin
Click to expand...

hiyall,

saw one of you speculating about 2-amino-tetralin and feel obligated to post
a warning story i heard from dear friend of mine:

it's absolutely vile stuff and should be avoided like the plague. yes the
rat studies look good, but no, humans are not rats and the data can not be
easily extrapolated.

my friends experimentation with this compound 8 years ago gave him a big life
lesson and he's lucky to still be here. now he's not so eager to test never
before been tried compounds. it's a fine line and i advise extreme caution
when working something up. some of my friends mishap was inexperienced
pilot error, after several days of ramping up slowly on seperate experiments,
he got impatient and boosted a double dose 3 hours after taking the first dose
(was getting slight effect from first dose and figured 3 hours was enough time
and should have peaked), then it all hit like a frieght train. very dysphoric,
nothing like amph, sedated, sick and wierd feeling, total agony. continued
accent and passed out completely unconscious at 4-5 hour point and came to
consciousness about 3-4 hours later completely surprized that he was still
alive. he was able to call friend for help at that point and seemed like was
leaving system slowly and was going to be OK. decided not to go to hospital to
avoid explaining situation and potential police inquiry.

friend took him to her
house and crashed in bed feeling sick and nauseous. some 6 hours later he
woke up middle of the night to go pee and on way into the bathroom passed
out completely (maybe due to low blood pressure) and did a face plant into
shower door slicing his face and severely breaking his nose. blood everywhere,
friend wakes up and sees him in pool of blood on the floor barely able to
maintain consciousness. was able to get bleeding stopped and then passed
out in bed from pain. awoke next morning in intense pain and found his nose
was on the wrong side of his face. required surgury, long recovery, etc. truly a
nightmare.

abandon hope all yee who enter here

sincerely,

purple heart
Click to expand...
...
 
Oh, right. The rat studies did look good, but that's a bit of a human disaster as regards dosing. Suppose that''l probably mean that the 3,4-didehydro version might well be dodgy as well.

Out of curiosity, do you know the dosde that caused him to black out?
 
Unfortunately, no.. I'm curious as to what this actually does in the brain now, as it sounds kind of like the methoxy-methylenedioxy-tetraisoquinolines from peyote that Shulgin reported about in the 70's (they had some weird effect on dopamine/dopamine neurons that I can't recall offhand).
 
Yeah there are various dialkyl (dipropyl mainly), ring hydroxy 2-aminotetralins that are specific agonists for various dopamine receptor subtypes, but I thought that ring hydroxylation was needed for directly acting agonists. The methoxy/methylenedioxy isoquinolines have oxygen atoms in the similar places as the dopamine agonists mentioned, so that might be the reason for their activity
 
I'm wondering about p-F aminorex. that 4-methyl just seems to weaken the whole thing. Aminorex is 20% stronger than dexadrine and I'm wondering about the substitutions. p-F is known but untested on humans. p-F 4MAR has been tested on humans. the 3,4 methylenedioxy would be fun to test...
 
Does anybody by any chance have a copy of the following paper I can have a peek at or have access to springerlink in order to get to have a look at it themselves?

Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol...
Ferris and Tang. J Pharmacol Exp Ther.1979; 210: 422-428

It also contains pharmacological data about 2-benzylpiperidine, which from what I can gather from looking at papers that don't cost $10 a shot is def active as a CNS stimulant (also contains info on desoxypipradrol)
 
Can't we gang together & get one member a yearly subscription. Of course, it falls on that person to keep churning out all the requests but still...
 
Nah, I eventuaslly got a copy due to responses by some very kind BLers (cheap bastid that I am).

Turns out 2-benzylpiperidine is as active as (+) amphetamine when it comes to noradrenergic reuptake. It just gets more & more interesting!
 
And it should be as cheap as chips to make. Legal as well :-) Who is betting that the 3,4 methylenedioxy is a close match for MDMA???
 
Is 2-BP controlled in any country? I assume it would be considered an analogue in some because of methylphenidate. Still looks like it should be a controlled drug, as in listed as one.

What else did the article say? sounds like it makes for a good read this article!

EDIT: Oh woops haven't been keeping up, is mentioned in the start of this thread. Interesting.
 
Good read, what do you think about

2-phenyl thiomorpholine

or possibly the phenmetrazine equiv (with extra methyl group)?

2-phenyl thiomorpoline seems to be commercially available. Also spotted it in a chem catalogue with various para substitutions F, MeO, CF3 (btw this is a proper looking chemical company as opposed to "research" chemical company, so would imagine they are sold as intermediates)
 

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Very interesting F&B. The trouble is it's not possible to tell just by reading those papers what the effects are likely to be like in human subjects :\
 
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