Stimulants of the Future

[haribo1]

^ Does 4-MAR not produce any sort of rush either? I was under the impression that it did of sorts (I will get to try the bloody stuff eventually - all these false starts, etc is just making me more & more curious!)

50mg smoked gave a very mild lift but nothing like amphetamines. I just felt happy, awake & focussed.

 

[haribo1]

If it wasn't why did the UK government feel the need to include it in the Misuse of Drugs Act...

Who can make sense of MoDA? Quite a few non-addictive compounds are listed (well, I guess you can get addicted to anything, I mean physical addiction). Things like LSD & DMT stop working if you overuse them.

 

[fastandbulbous]

^ Er paroxetine isn't in the MoDA, it seems that my brain is having a few backfires today - mind you, they originally said benzos were non-addictive, but look at all the shite associated with their prologed use nowadays

 

[haribo1]

Tell me about it. I'm on 12mg clonazepam per day. I don't feel anything. However, if I DON'T take it...

 

[fastandbulbous]

Fuck, and you were wondering how I coped with phantom limb pain. With all the greif you've been saddled with, what I get in terms of pain & distress would probably be a not too bad day for you.

There are times when we (by that I'm pointing at myself) don't appreciate how good things are in comparison to how bad they could be. I could be an amputee in a refugee camp in the Sudan if fate had decided otherwise.

Considering all the crap I've got myself worked up over in the last few days, I think I need to take a quiet moment and realize it doesn't matter, being alive and in a country like Britain is a pretty priviledged thing to have...

 

[Survival0200]

^^
Are you missing a limb?

 

[Helios.]

fastandbulbous,

Have you considered writing a blog in the Journal forum?

 

[Refluxer]

I need a little help from the Tribe of Bluelight:

Is the anyone that has tried 2-benzylpiperidine and can tell me a little about the actual effects in human?

If anyone of you SAR-geeks out there can dish me some predictions on how it may differ from methylphenidate, it would be much appreciated.

 

[haribo1]

F&B That pipradrol analogue I posted an image of is active in sub-milligram doses apparently. Worth a look? If only desoxy was a bit shorter acting...

 

[fastandbulbous]

^ Like 1 or 2 days shorter! 20mg on a Friday night could see you awake for the whole weekend!

 

[Refluxer]

C'mon ppl! I know a few of you have the knowledge to do some qualified SAR-guessing.

 

[vecktor]

C'mon ppl! I know a few of you have the knowledge to do some qualified SAR-guessing.

I don't like guessing but here goes:
I predict full activity at around 25-30mg. I will also hazard a guess that it is a DAT inhibitor without producing much in the way of euphoria unless smoked or snorted. I will also predict that it is shorter acting than desoxypipradol because it can be metabolised (oxidised) at the benzylic position.

 

[Refluxer]

Thank you Vecktor!

If compared to methylphenidate, it seems likely to last a lot longer, but is the ester group involved (or restricting?) in any actual binding? Does the lack of the ester group open up for binding to other receptors than the usual stimulant ones?

 

[haribo1]

Smoking desoxy gives a 30 minute rush, mental not physical.

 

[fastandbulbous]

I don't like guessing but here goes:

That's all I do most of the time!

Yep somewhere between 20-50mg range, longer lasting tha methylphenidate or its reverse ester as it doesn't have a handy metabolic handle. Probably excreted mostly unchanged (not many PEAs & derivatives metabolized on an unsubstiututed benzylic carbon) . Not mich at all in the way of physical effects. Basically like a little brother of desoxypipradrol.

I honestly think that 2-benzoylpiperidine would be a better bet (sort of beta keto 2-benzylpiperidine) as it'd be shorter lasting , but would show more physical effects than 2-nenzylpiperidine.

After all that, the morpholine derivative (3-benzylmorpholine) is the most potent of the series as it is with the diphenyl compounds, and it's not too difficult to synth using phenylalanine or phenylalaninol as a starting material (allows for synth of optically pure compounds very easily)

 

[Reminisant B]

Cyclopentamine

I was just browsing wikipedia - stimulants and saw Cyclopentamine , looks like a horrible propylhexedrine type drug. Anyone know anything about it first hand?

 

[fastandbulbous]

Cyclopentamine , looks like a horrible propylhexedrine type drug.

That sums it up perfectly. At first glance I thought you meant 2-phenylcyclopentylamine which is a useful, pleasant locomotor stimulant with antidepressant properties

 

[Reminisant B]

Just worked out the structure of 2-phenylcyclopentylamine, looks cool! (for want of a better expression).

Have you had experience with this compound then?

What about sticking a methylenedioxy on it ? Or would this not work for good reason, my chemistry fails me at this point or more likely pharmacology.

 

[Jamshyd]

That looks suspiciously close to Aminorex, does it not?

 

[fastandbulbous]

No (not yet )

The aryl-alicyclic amines have loads of potential, especially the ones made more rigid by a second ring (fencamfamine is just 2-phenylcyclohexylamine with a methylene bridge across the centre (or 2-phenylcyclopentylamine with a 3,5 ethylene bridge) and an N-ethyl group