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Stimulants of the Future

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Whats everyone think about the 4-fluro range of RC's like 4flurococaine and 4-fluor-methamp that seems to be getting added to everything does that make it legal or what. sorry for sounded dumb i am dumb right now.
and what health risk does the 4-fluro add or is it a more safer version. I wonder alot aobut this 4flurococaine 60 times more stronger sounds like a heart attack in one ay. from what i heard 4fluro drugs are bad for heart and coke is toxic as for heart destroying tissue on contact of the heart.
 
tadfish said:
Whats everyone think about the 4-fluro range of RC's like 4flurococaine and 4-fluor-methamp that seems to be getting added to everything does that make it legal or what. sorry for sounded dumb i am dumb right now.
and what health risk does the 4-fluro add or is it a more safer version. I wonder alot aobut this 4flurococaine 60 times more stronger sounds like a heart attack in one ay. from what i heard 4fluro drugs are bad for heart and coke is toxic as for heart destroying tissue on contact of the heart.
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^
perhaps they cause short term memory loss, focus difficulties, repetitive behaviours, as evidenced by repeat posting and failure to read the posted replies. :|




people should be aware that fluoromethamphetamine is not legal, and has only a narrow dose window, from mediocre effects at lower doses to downright unpleasant effects at 20-30% above. the material shows clear acute toxic effects. the n demethylated amphetamine appears less toxic than the methamphetamine, but this is all terra incognita.

4-fluorococaine (4'-flourobenzoyl ecgonine methyl ester) is not 60x more potent than cocaine, the related CFT is, but it is not around as it is very expensive and is synthesised from illegal cocaine, both CFT and 4-fluorococaine are illegal in quite a few countries.

it is 4-fluoro tropacocaine that has appeared in quantity this is 4-fluorococaine without the ester group, and seems quite effective in a compulsive coke kind of way, it is cheap and available.
 
A few weeks ago I had approx. 100 mg of 4-fluoro-tropocaine, which seemed to sedate me to some extend. Like, I got the urge to lay down and/or fall asleep. I've heard others had this too off this batch, could this be a botched synth or is it indeed less up than coke? In a way, it did feel like coke though.
 
My thoughts are still with the 3,4-di or mono fluorinated methylphenidates or the ethylphenidate/propylphenidate or some mixture thereof. They should exert very high affinities for DAT.

I wonder about 5-phenyl-1,3-oxazol-2,4(5H)-dione (pemoline with the imine replaced by a ketone).
 
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Mmm, something about that bariturate-like aminomalonate-esque moiety in 5-phenyl-1,3-oxazol-2,4(5H)-dione isn't sitting well with me. It's screaming hepatotoxicity...possibly even CNS depressant.
 
I'd be worried it'd be a GABA antagonist; all of these that are depressants are substituted IIRC. It's most similar to phenytoin, I suppose, but that's two phenyl groups like diphenylprolinol.

Obviously without similar activity though!

Is the monophenyl derivative of phenytoin known?

Hmm.. I'd be wary:

Xenobiotica. 1989 Dec;19(12):1471-81.
Related Articles, Links

Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.

Brown LP, Lewis DF, Flint OP, Orton TC, Gibson GG.

University of Surrey, Department of Biochemistry, U.K.

1. The ability of 20 mono- and di-phenylhydantoin derivatives to inhibit differentiation of rat embryo mid-brain and limb bud cells in culture has been used as an index of the teratogenic hazard represented by these compounds. 2. Molecular orbital calculations on these compounds, using the MINDO-3 (modified intermediate neglect of differential overlap) and CNDO-2 (complete neglect of differential overlap) methods, were combined with indices of teratogenicity in the two cell types, to generate a coherent structure-toxicity relationship. 3. Teratogenicity correlated with frontier orbital electron density of the N1 hydantoin ring atom (HOMO-N1) in a sub-series of 12 monophenylhydantoins, whereas the corresponding toxicity for both mono- and di-phenylhydantoins related more to the molecular polarizability (alpha mol) of the molecule. 4. Furthermore the same structural parameter (alpha mol) exhibited a parallelism with log P values of these 20 compounds, indicating the importance of lipophilicity in the toxicity of these compounds. 5. Overall, the data emphasize the ability of electronic structural calculations to identify chemical descriptors of toxicity.
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United States Patent Application 20040014992 has some neat compounds which are DAT inhibitors too -- non-nitrogenated ones at that.
 

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Isn't this 3-(1H-1,2,3-Benzotriazol-1-yl)-1-(4-methoxyphenyl)propan-1-one o-1793 or 94? I'm not sure which. It reminds me of the dimethocaine type stimulant.

Then O-1783 is one of these 8-thiabicyclo[3.2.1]oct-2-enes or "thiatropanes"? There were cocaine analogues with the nitrogen replaced by a carbon that was also quite potent. Hmm.. it says that the 3,4-dichloro thiatropane analogue is a potent and selective SSRI, 800x higher affinity for the serotonin transporter than DAT?
 
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So far, no one in here has yet to bring up the idea of selenium containing stimulants. Which is interesting, since there's already an active psychedelic containing selenium. The most likely candidate for a stimulant containing selenium would be 4-methylseleneoamphetamine. An analogue of 4-MTA with a selenium in place of the sulfur. I can't find any info on this compound, so it probably hasn't shown up in any articles.

As for the potency of this compound, it's hard to say here. I don't think it will be more potent than 4-MTA and will probably induce serotonin syndrome like PMA and 4-MTA do, which means it'll have some of the dangers of those two compounds. I doubt it will have psychedelic activity either (which PMA does have).
 
LuxEtVeritas said:
maybe i am just drawing a blank and have seen it but to my recall i cannot think of any selenium containing psychedelics,...please enlighten
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there is 2-C SE or whatever Shulgin called it in Pihkal which was mildly interesting.

selenium compounds generally are bad smelling, toxic and on the whole horrible.
 
Nepicastat - A dopamine beta-hydroxylase inhibitor intended to treat cocaine dependence. It may actually be sedating due to the negative effect on norepinephrine concentrations.

http://en.wikipedia.org/wiki/Nepicastat

Isn't this 3-(1H-1,2,3-Benzotriazol-1-yl)-1-(4-methoxyphenyl)propan-1-one o-1793 or 94? I'm not sure which. It reminds me of the dimethocaine type stimulant.

Then O-1783 is one of these 8-thiabicyclo[3.2.1]oct-2-enes or "thiatropanes"? There were cocaine analogues with the nitrogen replaced by a carbon that was also quite potent. Hmm.. it says that the 3,4-dichloro thiatropane analogue is a potent and selective SSRI, 800x higher affinity for the serotonin transporter than DAT?
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I'm not terribly sure. I went through the patent again but the wording escapes me.
 
vecktor said:
there is 2-C SE or whatever Shulgin called it in Pihkal which was mildly interesting.

selenium compounds generally are bad smelling, toxic and on the whole horrible.
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indeed it could be attached to anything but part of the criteria at least to me to call it such would be that it is at all truly worthwhile and indeed either superior to its non-selenium counterparts in some way as otherwise it is a dead end to the assumed goal of superior compounds and movements off SAR
 
nuke said:
Nepicastat - A dopamine beta-hydroxylase inhibitor intended to treat cocaine dependence. It may actually be sedating due to the negative effect on norepinephrine concentrations.

http://en.wikipedia.org/wiki/Nepicastat


I'm not terribly sure. I went through the patent again but the wording escapes me.
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i would think a DA beta-hydroxylase inhibitor would make the use of such compounds MORE pleasuable and thus how would it treat dependency...?

Such is a great compound area to improve compounds that have too pronounced NE and allow one to get more of the DA with less perhaps as well
 
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