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Stimulants of the Future

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Are you looking to invent something new (stimulant, opiate, psychedelic or entactogen?), test as many already existing known compounds as possible, find the best high ever, make a ton of money or just play around at work/school/multinational pharmaceutical research company?

You are hereby, to quote Wu Tang, cordially invited "take a free ride on my thoughts." PM me if you want. Tell me what kind of 100% legal chemical information you are seeking. I have been around the block a time or two, and I LIKE teaching people stuff they don't know but want to learn.
 
Refluxer said:
Fast and fab:

You mentioned 2-phenyl-3,6-dimethylmorpholine earlier. Can you dig up any references as I'm interested to read some more. And how about that molecule but with 3,5 substitution instead?
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Who, WHO? I know I'm wonderful but I don't feel the urge to communicate said gorgeousness in my name (quite a few people seem to think my name is fastandfabulous)! =D =D. Could be worse - one rather upset BL on the receiving end of some moderation thought to amuzingly call me fastandfuckedinthearse... What can you do in the face of the wit of a modern day Oscar Wilde!

2-phenyl-3,6-dimethylmorpholine wqs one of the battery of compounds fed to rats during my short bout of academia (I'll try and find my notes, but it's from 20-odd years ago & the spare room is full of crap that needs to be sorted); the reason it stuck in my mind, other than not being a controlled substance, is that the phenmetrazine series are quite a simple synth from phenylpropanolamine (no synth details for obvious reasons). The 3,5 dimethyl compound behaves more like an N-isopropyl substituted sympathetic agent (more peripheral effects such as pounding heart, dry mouth, sweating etc) and is possibly stearically hindered about the amine function due to increased rigidity conferred by the morpholine ring (expressed as only having a fraction of the locomotor stimulant/appetite supressant activity of the 3,6 or parent phenmetrazine)
 
Allright, thanks for the info. So you don't know if there is any published data on it except in your thesis? (Which, BTW, would be an interesting read. PM me if there is a possibility of reading it. PDF?)

I think I will have to go search some patents or something.


Helios: Why don't you educate us all instead?
 
fastandbulbous said:
2-phenyl-3,6-dimethylmorpholine
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There's acutally a patent on this compound:
Bibliographic Information

2-Phenyl-3,6-dimethylmorpholine. Siemer, Harm; Doppstadt, Adolf. (Ravensberg G.m.b.H. Chemische Fabrik). (1963), 2 pp. DE 1143201 19630207 Patent language unavailable. Application: DE 19570710. Priority: DE 19570710. CAN 59:15657 AN 1963:415657 CAPLUS

Patent Family Information

Patent No. Kind Date Application No. Date
DE 1143201 19630207 DE 1957-R21461 19570710

Priority Application
DE 19570710


Abstract

The title compd. (I) is an appetite depressant and exerts mild central stimulation. A suspension of 165 g. 2,5-dimethyl-2,5-dimethoxy-3,6-diphenyl-1,4-dioxane, 115 ml. H2O and 80 ml. concd. HCl was refluxed, cooled, and neutralized. The yellow oil was sepd., dissolved in 100 ml. MeOH, 75 g. H2NCH2CH(OH)Me added and the whole refluxed 0.5 hr. Then Raney Ni (25 ml.) was added, the mixt. heated to 110° with H of 150 atm., the catalyst removed, the alk. filtrate neutralized with HCl in MeOH, and the solvent distd. The residue was heated with 134.3 g. ZnCl2 to 220°, the melt dissolved in H2O and made alk. by aq. Na2CO3. The oil was taken up in ether and fractionated to give I (64%), b1.5 118-20°, m. 64-5° (ether-petr. ether); HCl-salt m. 169-70°.
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Thank you very much Heckyll!

Where can one find a good search engine for patents?
 
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The best, most long lasting, most outstanding, conscioiusness expanding,
mind-manifesting stimulant is greater than 70% pure, recrystallized from a minimum amount of boiling water methamphetamine hydrochloride (2-methylamino-1-phenyl-propane hydrochloride crystals).

I if you are worried about undenialalbe bodily and or mental toxicity, swtich to
(d)-2-benzylpiperidine.

Have I made my two points clear? [no caps lock used]
Phendimetrazines, as Butthead will tell you, SUCK.
 
Phendimetrazines, as Butthead will tell you, SUCK.
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^ Phendimetrazine isn't up to much as it's a tertiary amine and they're not much cop in heterocyclic anorexiants/locomotor stimulants. Once you move the methyl group around the ring you're back with a secondary amine, which is what you want. All you have to do is make sure the extra methyl group doesn't 'get in the way' of binding. Phenmetrazine (the parent secondary amine) is far, far from sucky. The reason Scandinavian governments went apeshit about stimulant use is because of IV phenmetrazine abuse (which is said to be more euphoric than the amphetamines)


Which, BTW, would be an interesting read. PM me if there is a possibility of reading it. PDF?
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I'd love to think I'd been let loose on a Ph.D., but it wasn't a full blown thesis (I'm far too lazy for that!) - it was part of a research project by one of the lecturers I had while doing my degree and only had the clout to produce an M.Sc., so I was reduced to an et. al. on the paper.


Heh...so people here don't listen to Beefheart...
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I know - uncultured heathens, the lot of 'em! =D
 
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fastandbulbous said:
The reason Scandinavian governments went apeshit about stimulant use is because of IV phenmetrazine abuse (which is said to be more euphoric than the amphetamines)
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I've read about it to, that the speed freaks actually preferred Preludin/Fenmetrazin/Fenmetralin. That's why I got interested in your find. :D I thought they had banned all the possible close analogs to the famous phenmetrazine, especially one so similar like the one you mentioned.

Maybe I should go try find someone old enough to have experienced the era first hand and see if the claim is true... ;)
 
Helios. said:
I if you are worried about undenialalbe bodily and or mental toxicity, swtich to
(d)-2-benzylpiperidine.
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Even though I'm unsure of the contents of the tabs sold that claim to contain 2-benzylpiperidine, the effects people describe show it's clearly a decent stimulant of some kind. But it doesn't really sound like the stimulant-dream-come-true. Pretty tough side effects and harsh comedown. Maybe people are just overdosing, I don't know. If someone has ready access to analysis instruments, maybe I can get ahold of a pill or two and send you. It would be very interesting to see analysis of these ones.
 
I've done was it either phendimetrazine or phemetrazine and it was smooth but it just didn't give me that thought rush of energy that ice does. The Scandinavian druggies were probably IVing it based on easy of availability more than anything.

These people got the name right except for the N part. I'm sure that's what it is. Its degree of optical rotation--which can easily be determined with either an analog or digital polarimeter--will indicate which method of synthesis has been used.

And kittyinthedark describes 2-piperonylpiperidine as "tasty."
 
Cocaine itself is already so valuable it makes its use as a precursor prohibitively expensive for almost all uses.

Synthetic routes to new, improved cocaine analogues not involving cocaine as a starting material tend to be either similarly horrendously expensive and or complex.
 
Now you need to reduce the ketone to the alcohol, prepare the acetate, separate the isomers, and you get the well known stimulant levophacetoperane, which is sort of the reverse ester of methylphenidate.
 
I know this sounds dumb, but I REALLY enjoyed 4MAR but plain MAR is supposed to be about 4 times more potent. The strongest of the series (ED50) was the 4-fluoro. Now, I know 4-F amphetamine isn't quite as speedy but a bit more happy. Wouldn't pFMAR be worth giving the once over? That or possibly a pseudohalogen?
 
haribo1 said:
I know this sounds dumb, but I REALLY enjoyed 4MAR but plain MAR is supposed to be about 4 times more potent. The strongest of the series (ED50) was the 4-fluoro. Now, I know 4-F amphetamine isn't quite as speedy but a bit more happy. Wouldn't pFMAR be worth giving the once over? That or possibly a pseudohalogen?
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4-MAR is 4-Methyl-Aminorex. What do you mean "plain MAR"? Do you mean Aminorex without the para-methyl?

With that in mind, there can be no such thing as "pFMAR" as aminorex can either have an para-alkyl or a para-fluoro...but it can't have both. I assume you mean 4-fluoro-aminorex.
 
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