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Stimulants of the Future II

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There's been lots of talk about it... but how come nobody's synthesized lefetamine yet? I know it's old, but still the structure is so nice. Compare the structure to morphine. It's something. I know some possible ways to make if you have some common reagents (which i don't).
 
Lefetamine has been made, by a few members here (well, the racemic product anyway) and it doesn't seem as wonderful as it's constantly made to seem. The opioid affinity isn't high enough that it becomes strong enough to enjoy at doses where the stimulant effect is very pronounced.
 
Right well I guess that makes sense, even if it is as strong as morphine, morphine isn't that active at the same dose as methylphenidate. Still perhaps good for a stimulant, I can totally imagine what that guy said about "laid back quality" with fencamfamine (which also seems interesting)...
 
Oh yeah, I'm only aware of psychopharm., I was just curious. Someone oughta make that stuff ... one of these days ... oh yeah ...
 
well cyclopentadiene & nitrostyrene (makes the primary amine which then requires N-ethylation). I've talked to one person who has synthed a little and it doesn't seem that complicated (easier than LSD, but more complicated than meth!).

Although the N-ethylamine is the least toxic (seems to hold true for a lot of stims like N-ethylcathinone being the least toxic with appreciable activity), the N-methylamine derivative of the primary amine might be interesting to synth as it's only twice the toxicity (fencamfamine is remarkably non-toxic) as it might have more opiod activity as well as the stimulant side (most opioids are mostly N-methylsubstituted, higher simple alkyl producing unwanted side effects eg petazocine vs metazocine). The other highly active N-substitution for opioids, N-phenethylamine) would probably abolish stimulant activity, or at least reducde it to negligable activity
 
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disubstituted primary amine
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That's an oxymoron I think =D

Anyways I had an idea for a stimulant today. This is a kind of open-chain variation of a phenyltropane...

stim1.png


Without going too much into synth discussion, this should be entirely possible to synth from phenylalanine, I think. And I'm willing to bet it would have DRI activity quite similar to that of troparil.
 
dread said:
That's an oxymoron I think =D

Without going too much into synth discussion, this should be entirely possible to synth from phenylalanine, I think. And I'm willing to bet it would have DRI activity quite similar to that of troparil.
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count the carbons.... this needs special chemistry, or special chemists or chemists who are special
 
What's up with this opioid receptor talk for stimulants?

I want absolutely zero opioid effects from stimulants. The idea stim for me would be MDPV with some GABA mixed in.

Either that or for productivity and physical transparency propyl-amphetamine can't be beat.
 
Oxycodone like all of those morphine derivates are dopamine agonists as well as opiod agonists. D1/D4 dopamine agonists have some stimulant effects, D2/D3 agonists just make people spew.

""D1-selective full agonists like SKF-81297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine""
 
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