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Stimulants of the Future II

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It looks alright. "Superior" to amp was what you read in the patent though right?
 
Yeah that quote was part of the abstract for patent 4022786... I'm not much of a chemist but I think if you can attach something to the 4-position of piperidine, you'll be all set.
 
^ most of the people in this thread frighten me. so much enthusiasm so little knowledge.

you might want to look up the selective toxicity/lethality of 4 diphenylmethyl piperidine to beta cells in the islets of langerhans before you get too carried away. the 44 diphenyl compounds appear much safer.

also can people keep away from synthesis discussion if possible?
 
vecktor said:
^ most of the people in this thread frighten me. so much enthusiasm so little knowledge.
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This scares me also, not so much the posters themselves but more the fact that some RC dealer who knows chemistry but not pharmacology might read this thread and think these compounds sound like great ideas for new product lines 8o
 
I really like that amphenidate idea/ methylamphenidate. Obviously, the methyl acetate makes a large difference to 2-benzyl piperidine, which is only a strong norepinephrine reuptake inhibitor. As such one can only guess what effects amphenidate would have.

Except that -HN-NH2 in your drawing is supposed to be -HN-CH3, right?
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Yes indeed, chloral hydrate, that NH2 group was a kind of "typo".

Here's the corrected version of MethAmphPhenidate:


methyl%203-(methylamino)-2-phenylbutanoate46.png



Thank you for your positive feedback chloral hydrate. (it's offtopic but hey: I like the hypnotic properties of chloral hydrate as well very much as well - especially for coming down after high doses of Amphetamine it is really reliably... ;-)

However I'm quite sure that - if this compound would act as I expect - this compound could be made even more potent by attaching an additional 3,4-Methylenedioxy group to the benzol ring.


-------------------------------------------------------------------------------------


I've just had another idea for a future stimulant while thinking about 4-MAR derivatives:


4-methyl-5-(4-methylphenyl)-4,5-dihydro-1,3-oxazol-2-
amine:

4methyl54methylphenyl45.png


I guess the additional 4-methyl group would lead to increased(/addtional?) and it was quite easy to synthesise, too...

If my theory about this compund was correct I'm quite sure that "4-MethylMethAminorex" will appear on the RC market soon... =D
 
Haha thanks when I made this account I was totally psyched about making chloral hydrate but I failed miserably and haven't tried since... I can only assume you've made it though?

The aminorex compound should be just like analogous to mephedrone I suppose? Might be synthesizable from mephedrone...
 
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If it does, are you going to take any of the credit for it?
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If I really was the first who thought about it...
...why shoudn't I at least a little bit? ;)



Haha thanks when I made this account I was totally psyched about making chloral hydrate but I failed miserably and haven't tried since... I can only assume you've made it though?
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Hehe...

No not yet - but a friend of mine got a prescription for it so I could test some of those quite big 500 mg capsules. The first time I took 1500mg after don't-ask-me-how-much-D-Amphetamine (but it was *A LOT*) and I felt asleep very quick and gently (it's not as unpleasantly as high doses of Phenobarbital at all!) so I could relax and look forward waking up again and playing the same crazy but very funny and recreational game again... =D

Another friend of mine who's studing chemistry and already synthed it sayed it was laughably () simple to make chloralhydrate but since he told me you needed to handle with chlorine gas that is released while the synthesis convince me not to try this in my kitchen ;)



The aminorex compound should be just like analogous to mephedrone I suppose?
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Exactly. But I think the 4-Fluro version might be nice, too.


Might be synthesizable from mephedrone...
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Possible is almost everything. But I think total synthesis would be much more cost efficent.




@Hammilton:


I think we had a bad start. What about starting from the very beginning again? :-)
So maybe I should first introduce myself a little bit - like civilized people do:

My (nick-)name is c0rt3x (That's Leet-Speak for "Cortex" )
I'm a 23 years old guy from Germany who's very interrested in (mainly - but not only) in: (IT-)Technology, Computers, Programming, Chemistry, Pharmacology - and of course drugs - espacially in combination with electronic music =D.
I am - or let's better say - I was suffering under strong chronic (back-) pain and a highly pronounced attention deficit disorder at the same time. When I was 18 I decided to give a fuck about those (especially my parents - but many, many "doctors", too...) you tried to "save" me from "terribly" "bad" and "dangerous" drugs like opioids and amphetamines. But in *FACT* they saved my life by preventing me to kill myself because of enduring suffering all-day-long. Furthermore after I finally could almost completely defeat my chronic back pains by telling my doctor to prescripe me buprenorphine transdermal patches. And I had to visit a *LOT* docs to finally find some female "doctor" who was at least clever enough in order to listen and understand my very well thought, based and in many cases even provable arguments and after a long and horrible time of all that ignorance of very-most "doctors" (wich call them selfs euphemistically) "pain-experts" :! - But in fact my experience prooves that most of those docs who "studied" medicine for about 10 years + some more years especially for "pain threatment" seem to know less about opioids than me who did nothing more than reading some wiki-articles about different pain medications. Most of them even prefer to let you die by suicide - because of unbearably pain - instead of doing their motherfucking over-paid job and give you a simple piece of paper wich would allow you to live a livable life again. And thats only one single tiny aspect of all the absolutely unnessesary bullshit which is happening every day around the planet since the beginning of the prohibition - for any "good" reason - (than money-making) :(. This really unbelievable sad and inhuman.


...


OK I think I really digressed very far now. But whenever I think again about my past and all that incredibly unnessesary pain hat I had to endure - I get motherfucking angry and sad - and I just had to abreact myself a little bit...

...



Would you mind to tell me a little bit about you, too, Hammilton? Of course you could PM me if you don't like to "puplish" personal information about yourself...
 
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If I really was the first who thought about it...
...why shoudn't I at least a little bit?
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Because you don't deserve any? I don't mean this to be rude and I would feel the same for anything else- mental creations for which no legwork has been done don't count as creations.

For what it's worth, I have that structure along with about 20 variations in a chemdraw file dated June 30th 2008. Incidentally, that was the day of my wedding; I remember doing some reading that morning, but not actually drawing it, but I'm fairly certain the date is accurate. I didn't invent it any more than anyone else has. Until someone has actually made it and tested it, there's no point in assigning credit.

And then there's only value in creating it if it's good. Or MPTP horrible. No one cares about the guy who 'came up with' "methedrone" only mephedrone (whoever that was).
 
Has 2-Methylamino-1-phenylbutan-1-one been tested by humans? Or can someone speculate what kind of stimulant it would be?
 
I doubt it's that interesting. Methcathinone with an ethyl group at R-a instead of a methyl. Probably a bit weaker than methcathinone since the main point of R-a is to inhibit oxidation by MAO enzymes and the methyl group is sufficient. And modifications like this have been beaten to death already. More interesting modifications are perhaps cyclisizing something as it is in methylphenidate or phenmetrazine or aminorex. But that's just my opinion.
 
If you like chloral hydrate, perhaps try making chlorobutanol (aka chloretone). It's definately easier to make than chloral hydrate, but it has a stronger taste (especially when you inevitably burp it up). Still, worthwhile if you like the sort of thing (not an advocation drug synthesis)....

Also, this compound is not especially original:

4methyl54methylphenyl45.png
 
almost- said:
Has 2-Methylamino-1-phenylbutan-1-one been tested by humans? Or can someone speculate what kind of stimulant it would be?
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Dosage is around 10-30mg so its considerably more potent than Methacthinon but a little shorter acting.And its not comparable in its subject effects,way less jitters/peripheral stimulation,just a rather clean stimulant.It surely is more on the dopaminergic side.The C4 chain appears the optimum in regards to the overall profile (at least in my view).Altough you can get higher with Methcath (with all its consequences).Mebutamin appears waayy cleaner in this regard.
 
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