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Bupe St. Johns Wart Potentiaing Suboxone???

spacejunk said:
^ i really hope you're using a micron filter.
I know everyone has their preferences; but there is really very little point injecting buprenorphine.
Have you tried taking sub-milligram doses? Plenty of people seem to - paradoxically - get more better effects from less.

The idea, to put it in very simplistic layman's terms (the best i can offer, i'm afraid!) has something to do with bupe's (more active) metabolites having the chance to bind to your receptors, rather than being flooded out by bupe which has such a high binding affinity.

Very much off topic, but if you're going to experiment...there are people that swear by the "less is more" mantra.
YMMV, but seriously - I think the risks of shooting bupe greatly outweighs any benefit.
If you want to increase bioavailability, there is the trick of swishing a small amount of alcohol around your mouth before sublingual administration. I take it you are using suboxone pills (as you mentioned snorting) - insufflation also has better bioavailability for bupe than the sublingual ROA, and would be preferable - especially if you are using every day - to banging it.

I don't mean to have a go at you - I'm glad you added the disclaimer at the end of your post - but I think it's worth trying something other than what you describe, frankly. There are much safer ways of achieving what is more or less the same effect, and frankly I don't think IVing buprenorphine is worth the risk of serious complications

I understand the ritual of injecting is a major component of lots of people's habits, but suboxone can help you leave that part of it out of the equation, with its bupe's potency, duration and so on.

Please don't take this as a lecture - just a friendly suggestion.
You're gonna do what you're gonna do, but it would be remiss not to suggest safer practices and routes of administration.
Click to expand...



Spacejunk I like you no worries pal I dont take any offence to what you said sillygoose.
I listen and I agree I was on strips but got switched to the orange AN round generic pills and I have to say I agree les is def more I read about it all the time cause the NORbupe is a full agonist and has room to go to your receptors instead of just bupe flooding them like you said!

anyways I dont always shoot subs I was just saying to get a rush actually yesterday I took it sublingually I get so upset with my self tho cause it is a ritual and I do hate the needle (well love hate) and suboxone does have many complications when IVed its very dangerous like you said it is my fetish but im trying to strain away from that but I only do that when I try to exceed low doses but you know what I never tried the alcohol thing
I have read about it many times maybe ill do it and yeah I do have micron filters witch I did forget to mention in my post if your going to bang diph and bupe deff use that but like I said I just do that when im low or something but I will take that into concideration

I think im doing to try it today and melt suboxone after swishing some captain in my mouth haha =D

and dont worry I never take offence im a peaceful spirit I actually appreciate everything you say buddy and yeah ill do anything to avoid the needle but I actually traded the last of my pills for strips cause honestly I dont like the pills AT ALL! YUCKKY

but again pal thanks foreal I dont get mad I rather hear new and take new suggestions
 
actually I just took 900mg of sjw then swished my mouth with nasty absolute vodka yuck my lips are inflammed from doing that and then stuck the whole strip under my toung I hope this does something %)
FINGERS CROSSED
 
Oh haha I get it thanks for the post I was so confused I would try that its just a flower I seen so many posts with it spelt wart not wort remover so I thought it was that stuff you use to freeze warts or whatever lol
 
jaysofab said:
actually I just took 900mg of sjw then swished my mouth with nasty absolute vodka yuck my lips are inflammed from doing that and then stuck the whole strip under my toung I hope this does something %)
FINGERS CROSSED
Click to expand...

How did it work?
Let me know
 
jaysofab said:
actually I just took 900mg of sjw then swished my mouth with nasty absolute vodka yuck my lips are inflammed from doing that and then stuck the whole strip under my toung I hope this does something %)
FINGERS CROSSED
Click to expand...

How did it work?
Let me know

And I can buy this at a health food store?
 
I just wanted to say I took the 900 sjw and swished vodka around then melted an 8mg/2mg sub strip and it absorbed better fer sure I achieved a high today weirdly but I been staying on low doses and upped it witch is weird
 
like im nodding right now I feel like when your blood levels of bupe lower even tho your taking low doses to have NORbupe work then you take a higher dose you can feel it I garuntee the sjw and alcohol ( I DIDNT SWALLOW THE ALCOHOL SWISHED AND SPIT ) had a lot to do with it lol just sayyin

wanted to thank you for this Idea cause im not going to shoot my suboxone any more just snort low doses and every couple days instead of taking 8 ill take my whole dose of 12mg but I usually do no more then 3 a day to keep tolly low.

and I just wanted to say spacejunk thanks pal (helped me strain away from the needle witch a much less harmer form of dosing the needle is never good ecspecially the way I was doing it but thats literally the only way to get a rush slammin it is adding DIPH again I would never tell someone to this its really unsafe and not a good habit)
I LOVED THIS ROA! MOA!
rout of administration
does MOA mean method like adding the sjw an hour before then the alcohol then dosing suboxone
 
Last edited:
If that is the case and St Johns Wort potenciates bupe then barbiturates are the ultimate potenciators, since they affect the CYP2D6 enzyme. I've had the pleasure of trying amobarbital, phenobarbital, benzobarbital and butabital, the first being the best and I think this would be an amazing combo however even a small dose of the other barbies would be good to potenciate the effects just not as euphoric. I would also look into Soma/carisoprodol which involves CYP2D enzymes as well.
 
thanks for recommendations only problem I cant do benzos on my maintenance program Id love to I havent even done a benzo or barb in 6 months haha they made a new law tramadol and soma cant be mixed with suboxone they found out it increases it dramatically
 
http://www.ncbi.nlm.nih.gov/m/pubmed/11673747/?i=5&from=/10223772/related

I hate to bump this, but for anyone attempting this in the future, only CHRONIC administration of SJW induces CYP3A4. This isn't surprising, as enzyme induction is a different ball game than inhibition.

Also, according to that study, SWJ only induces CYP3A4, so it is not a "broad" inducer.

So to do this, you'd need to take the SJW for several days, at which point it should at least double the amount of norbupe.

But I wouldn't waste my time. I personally think the norbuprenorphine thing is overrated. Oral use yields more norbupe than bupe, and yet oral buprenorphine is considered universally ineffective.

Oh well, at least people will have the facts in the future. Shows the placebo effect is alive and well, for the opioiphile people claiming a single dose had any effect!
 
when taking any kind of opioid or benzo St. John's wort should be avoided! SJW causes your liver to metabolize both classes of drugs with an unnatural quickness, resulting in both a lower peak plasma concentration and a noticeable reduction in duration of desired effects/high.

I started messing with SJW while taking suboxone, Valium and gabapentin... Hoping it would ease my depression, it did not. Worse still I felt like the subs were wearing off earlier than usual, and I wasn't noticing the Valium at all, did some research and sure enough...

Perhaps SJW would make opiate or benzo WDs better by hastening the process?
 
To jaysofab: it was the vodka, not the SJW, that boosted your subs. Having some alcohol in your mouth while your sub dissolves results in a much more efficient absorption. I used to use listerine mouth wash right before putting in my strips, it really helped, I can't remember why, but it wasn't placebo... And I don't mean get drunk when u dose your bupe sublingually, that sounds like a headache, simply having some potent alcohol, not much, in your mouth as u dose is all u need
 
idk man the sjw honestly works for me I dont think its a placebo like it could be but I really dont think it is because when I do take it I do notice more desirable effects then usual I mean I havent done benzos in over 7 months im hoping to score some klonopin then take some with my subs to get really fucking high hahaha
 
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