hmm not sure about 5ht1a pal. i read that it actually downregulates them. could you post a link to where you read about the 5ht1 UP-regulation?
"Pharmacopsychiatry. 1997 Sep;30 Suppl 2:113-6.
Effects of long-term administration of hypericum extracts on the affinity and density of the central serotonergic 5-HT1 A and 5-HT2 A receptors.
Teufel-Mayer R, Gleitz J.
Source
Department of Naturheilkunde, Ulm University, Germany.
Abstract
Extracts of St. John's wort, Hypericum perforatum L. (Hypericaceae), are used as a phytotherapeutic antidepressant. A number of clinical studies demonstrate that their antidepressive potency is comparable to tricyclic antidepressants (TCA). Although the therapeutic effect of hypericum extracts is well documented, very little is known about the molecular mode of action. As the improvement of the depressive symptoms with both TCA and hypericum extracts only occurs significantly after a lag phase of 10 to 14 days, it is assumed that the medication causes long-term adaptations within the central nervous system. In this context, serotonergic (5-HT) receptors are of special interest. Therefore, we investigated possible alterations in affinity and density of 5-HT1 A and 5-HT2 A receptors caused by long-term treatment of rats with St. John's wort. The brain without cerebellum and brain stem of rats, treated daily for 26 weeks with a commercially available hypericum extract (2700 mg/kg LI 160) were used for membrane preparations. Affinity (KD) and amount (Bmax) of serotonergic receptors were determined by employing receptor binding assays using 3 H-8-OH-DPAT and 3H-Ketanserin as selective radioligands for the 5-HT1 A and the 5-HT2 A receptors, respectively.
We found that in hypericum-treated rats the number of both 5-HT1 A and 5-HT2 A receptors were significantly increased by 50% compared to controls, whereas the affinity of both serotonergic receptors remained unaltered. The data suggest an upregulation of 5-HT1 A and 5-HT2 A receptors due to prolonged administration of hypericum extracts. These results are consistent with a modification of the expression levels of serotonergic receptors caused by synthetic antidepressants.
PMID: 9342771 [PubMed - indexed for MEDLINE]
MeSH Terms, Substances"
There you go, pal. Go read up old post about regaining the magic aswell, there's lots of studies cited there as well on imminst.com.
EDIT: for those of you who don't know, hypericum is the active ingredient in SJW.
) store. although i bought mine at GNC cause tbh i dont trust walmart. i really doubt the FDA is gonna check to see if wally-world is puting legit ingredients in its' meds.