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SSRI's and tryptamines

Tsukasa

Tsukasa

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Joined
Sep 21, 2007
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So i'm planning on tripping on some 4-acetoxy-dmt tommorow, the synthetic equivalent of psilocin/psilocybin. I'm dependent on tramadol, which is partially an serotonin-reuptake inhibitor. Would it weaken the effect of the 4acodmt? Even if i took a baseline or sub-baseline dose?

If so, what can I use as a substitute for the tram to keep wd's away? I'm definately taking poppy pods to take care of the opioid part of wd's. I still have to fill in the serotonin and norepinephrine hole, and make a small hole in NMDA (tram is also a mild nmda antagonist). I have DL-phenylalanine, l-tryptophan, 5-HTP, green tea extract, mucuna pruriens extract, and DMAE. I'm guessing the first two amino acids would be the best choice.

I also plan on smoking clove cigarettes and small amounts of cannabis, but their shouldn't be any negative interactions I assume. Also, will the 4-aco-dmt kill my appetite? My friend and I are bringing copious amounts of food, and i don't want it coming right back up.

Last question - What would be a good dose for a first timer and how should it be administered? My only other experience with tryptamine psychadelics is 110ug's LSD which was just a psychey buzz. I only have about 5 hours, and the effects last 6 hours i've read. After that I'll be around one of my parents, so I would prefer not too strong of a dose. Please consider that i'll be toking a bit too.
 
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^ I'm gonna need a better answer than that. Any research papers? or real psychonaut retrospective experiences? People who've done something like this before?

One of my friends is saying that H almost killed his 4-aco-dmt trip.
 
Well considering tramadol as you say is only a partial SSRI then it should stand to reason that if people on SSRI antidepressants can trip relatively unscathed on tryptamines and other psychs. but I hear SSRI users experience an increased phenethylamine threshold or tolerance kinda thing. Perhaps the H just overpowered the 4-AcO-DMT, if H is anything like I imagine it to be then its not surprising.
 
AFAIK, SSRIs and serotonergic psychedelics have no interactions other than blocking the effects of psychedelics and effectively making you need more to reach the same effect.

Regarding appetite, you probably won't want to eat anything during the peak, but personally I love eating during the coming down phase of psychedelics. The tastes are just so enhanced (much like other senses).

Regarding dose, you should check out the Big & Dandy 4-AcO-DMT thread (you will find the link in the Essential Reading / Index thread) for more information.

Oh, and BTW, LSD is not a tryptamine. It is an ergoline (which actually contains the backbone of both phenethylamines and tryptamines). :)
 
LSD & SSRI seem to exist reasonably happily from what I've obseved in others. How the opiod action of tramadol would effect the LSD is difficult for me to say because I've never used tramadol - but as a rule opiates/oids subdue the effects of LSD IME. I wouldn't mix them personally.
 
Sorry for not answering the SSRI part, but I would like to concur with some of the prior posts about the effect of opiates on tryptamines.

I have made the mistake of dosing acid, and them blowing oxycontin. That was stupid. What a waste. Either one by themselves would have been more enjoyable from my perspective.

It sounds like you are pretty knowledgeable about this subject though, so I'd say follow your intuition here, Tsukasa.
 
The come up was a bit rough. I had eaten some jalapeno and lime tortilla chips, melon bread, and these strange german gummy candies. I even smoked some pot. I ended up projectile vomiting up just the tortilla chips through both my mouth and nose... I'll remember not to eat anything when dosing next time, and save it for the comedown. The actual trip wasn't too bad, but I feel like I could have gotten more out of it. It would have been better at night like shulgin suggested, where the visuals seem to be more prominent. A higher dose would also be good.

The poppy pods with some cocoa bean extract where enough to chase away the tram wd's, but a while into the trip I started to feel depressed. Smoking djarums didn't seem to help much. I think i'll be alright though

Thank you all for your advice, I would have took it if i'd read it sooner. But after my initial experimentation with 4-aco-dmt, i'll be much more comfortable with it next time.
 
What was your dose Tsukasa ? And at what time did you dose and what time prior did you stop tramadol intake ?

edit: also, what is your daily tramadol intake ?
 
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